CV Science

Fabrice Antigny Ion Channels in cardiovascular research

Course and current status

2019: Accreditation to conduct research (HDR)

Since 2017: Associate Professor (Chargé de Recherche (CR1) INSERM, Ph.D) - UMR_S 999 - INSERM - Université Paris-Saclay - Pr. Marc Humbert's lab

2013-2017: Post-Doctorat #3 (University of Paris-Sud, Le Plessis Robinson, France) -UMR-S999-INSERM Pr. Marc Humbert's lab- Role of ion channels in the pathophysiology of pulmonary hypertension.

2011-2013: Post-doctorat #2 (University of Geneva, Switzerland) Pr. Laurent Bernheim's lab - Role of TRPC/Orai1 calcium channels in human endothelial cell functions.

2009-2011: Post-doctorat #1 (University of Geneva, Switzerland) Pr. Maud Frieden's lab - Role of TRPC/Orai1 channels in human myogenesis.

2005-2008: Ph.D. at the University of Poitiers, UMR_S6187  CNRS - Calcium homeostasis in cystic fibrosis epithelial cells (F508delCFTR). Thesis supervisors: Dr. Vandebrouck and Pr. Becq.

Scientific summary

My primary focus is deciphering the role ion channels signaling in the development of pulmonary hypertension at pulmonary and cardiac levels.

For Ultima, the goal is to identify and validate potential therapeutic targets.

Since my Ph.D. in 2008, my research has aimed to understand the physiological and physiopathological role of different ion channels. Now Fabrice is co-director of team 2 of the research unit INSERM UMRS_U999. The current research topic of my team focuses on ion channels and genetic predisposition in the pulmonary vasculature and right ventricular cardiomyocytes and their pathophysiological contribution to Pulmonary Hypertension.

Our current goal is to understand better the role of ion channels in the pathophysiology of PH and their potential impact as innovative therapy in PAH to reduce pulmonary vascular remodeling and right heart failure.

Through our research, we made significant progress in highlighting the functional remodeling of several ion channels, including KCNK3, ABCC8, CFTR, Orai1, and TRPC, during the development of PH at pulmonary vascular and cardiac levels.

Scientific production: Dr. Antigny is a highly accomplished researcher with over 50 original research papers and 20 review articles (ORCID ID: 0000-0002-9515-6571). Dr. Antigny has been invited to speak at several national and international conferences. He is also a dedicated mentor and has guided multiple Ph.D. scientists.

Skills and expertise: Ion Channels, Pulmonary hypertension – Pulmonary Vascular remodeling – Right Ventricular remodeling – Electrophysiology – Pulmonary arterial tone – Pulmonary arterial smooth muscle cells – Endothelial cells – Preclinical models.

Website: http://www.u999.universite-paris-saclay.fr/fr/equipe-2/kcnk3-nmda.html