CV Science

Sophie Polo , PhD cell and molecular biology

Course and current status

Junior group leader, Epigenetics and Cell Fate Centre, Paris VII University, Paris, France (since 2013)

Junior research associate (CR2 Inserm) at the Institut Curie, Paris, France (2012-2013)

Post-doctoral fellow in G. Almouzni laboratory, Institut Curie, Paris, France (2010-2012)

Post-doctoral fellow in S. Jackson laboratory, Gurdon Institute, Cambridge, UK (2006-2010)

PhD in cell and molecular biology, Paris VI University, G. Almouzni laboratory, Institut Curie, Paris, France (2002-2006) 

Qualified teacher holder of the Agregation in Biology (2002)

Alumni from Ecole Normale Supérieure de Paris rue d’Ulm (1998-2002)

Scientific summary

In the nucleus of eukaryotic cells, the genetic material is organised with histone proteins into chromatin, whose integrity is key for preserving cell identity.

My research focuses on the mechanisms underlying chromatin dynamics in response to genotoxic stress using cultured mammalian cells as a model system. By combining molecular and cellular approaches with advanced microscopy techniques, my aim is to identify factors involved in regulating chromatin dynamics and their functional relevance for the maintenance of genome and epigenome integrity in response to DNA damage.