David RIBET PhD Microbiology, Research Associate, INSERM

Course and current status

Since 2017 : Research Associate (CRCN INSERM) in "Nutrition, Inflammation and Microbiota-Gut-Brain Axis" Lab (INSERM UMR 1073; Pr. Moïse COËFFIER), Rouen University, Rouen, France.

2011-2017 : Research Associate (CRCN INSERM) in Bacteria-Cell Interactions Lab (INSERM U604; Pr. Pascale COSSART), Institut Pasteur, Paris, France.

2007-2011 : Post-Doctoral fellow in Bacteria-Cell Interactions Lab (INSERM U604; Pr. Pascale COSSART), Institut Pasteur, Paris, France.

 

Diplomas :

2016 : Habilitation à Diriger des Recherches (HDR)

2009 : Training in Cellular Microbiology (Diplôme Universitaire), University of Lille, France.

2007 : Ph.D. in Microbiology / Virology, Paris Diderot University, France.

2003 : Master's degree in Microbiology / Virology, Paris Diderot University, France.

2002 : Agrégation de Sciences de la Vie et de la Terre.

2001 : Bachelor's degree in Biochemistry, Paris Diderot University, France.

1999-2003 : Training in Ecole Normale Supérieure de Cachan, France.

Scientific summary

Role of the gut microbiota in eating disorders

  Anorexia Nervosa is a highly morbid disease characterized by serious malnutrition and intestinal disorders. Prevalence of anorexia ranges between 0.3% and 0.7% and steadily increases in most countries. Efficacy of current treatments is limited as 40% of patients show prolonged nutritional and digestive impairments. Better understanding and alternative therapies for anorexia are thus strongly required. A majority of anorectic patients display functional gastrointestinal disorders such as altered gastric emptying, delayed intestinal transit with altered motility and visceral hypersensitivity. These disorders alter the quality of life and challenge refeeding strategies. Targeting of these intestinal disorders thus constitutes an interesting strategy to improve treatments efficiency. Our work aims to explore the role of the gut microbiota in the onset and maintenance of the gastrointestinal dysfunctions associated with Anorexia Nervosa. By providing new insights in the pathophysiology of Anorexia, we hope to identify new therapeutic approaches based on gut microbiota modulation, which will complete the refeeding and psychological approaches currently used in clinics.

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