CV Science

Estelle Oberlin Role of the microenvironment in the regulation of human embryonic, adult and neoplastic hematopoietic stem cells

Course and current status

• Researcher | Jan 2004 To Dec 2025 |Inserm U1197 “Interactions between stem cells and their niches in physiology, tumors and tissue repair (SToRM)” , Villejuif , France

1.      Role of the Microenvironment in the Regulation of Human Embryonic, Adult and Neoplastic Hematopoietic Stem Cells

2.      Immunosuppresive and Immunomodulatory Properties of Human Fetal Liver Mesenchymal Stem Cells

• Researcher | Jan 2000 To Dec 2003 | Inserm U935  | Inserm U602  | Inserm U506, Villejuif, France

1.      Identification and Characterization of Endo-Hematopoietic Stem Cells in the Human Embryonic Liver

2.      Identification of Hemogenic Endothelial Cells in the Human Embryonic Aorta

• Post-Doctoral Fellow | Jan 1997 To Dec 1999 | Theodor Kocher Institute, Bern, Switzerland

1.      Signal transduction by Chemokine Receptors in Human T Lymphocytes

• Ph.D Fellow | Sept 1994 To Dec 1997 | Pasteur Institute | Paris, France

1.      Chemokines and Chemokine Receptors Involvement in Human Immunodeficiency Virus (HIV) Infection

Scientific summary

My research is carried out in the Inserm unit UMR-S-MD 1197 created in 2020 for 5 years and entitled "Stem cell-niche interactions: physiology, tumors and tissue repair".

The principal research axis to which I am devoted proposes to study and characterize the bi-directional niche/ hematopoietic stem cell interactions in physiological situations in the human embryo and during the adult life as well as in acute myeloid leukemia.

I am also studiyng the immunosuppresive and immunomodulatory properties of human fetal liver mesenchymal stem cells versus neonatal and adult mesenchymal stem cells.