Marc-Emmanuel Dumas
  • E-mail :[email]
  • Phone : +33 3 74 00 81 00
  • Location : Lille, France

Scientific topics

Keywords

ITMO

Last update 2023-09-22 17:47:48.061

Marc-Emmanuel Dumas Ph.D. (Biochemistry, Molecular and Cell Biology)

Course and current status

• 2023. CNRS Director of Research, European Genomic Institute for Diabetes (EGID), U1283 INSERM / UMR8199 CNRS, Institut Pasteur de Lille, Lille University Hospital, Université de Lille, France.

• 2022. Director, Imperial-CNRS-ULille International Research Project in Integrative Metabolism.

• 2021. Director of metabolomic platform IMPACT-PM – European Genomic Institute for Diabetes (EGID), U1283 INSERM / UMR8199 CNRS, Institut Pasteur de Lille, Lille University Hospital, Université de Lille, France.

• 2020. CNRS senior investigator (CRCN), Head of "Metabolome, Microbiome and Metabolic Diseases" group, workpackage leader "Nutrition and Environment" in the IHU2 National Centre for Diabetes Precision Medicine "PreciDiab" – European Genomic Institute for Diabetes (EGID), U1283 INSERM / UMR8199 CNRS, Institut Pasteur de Lille, Lille University Hospital, Université de Lille, France.

• 2019. Chair in Systems Medicine, Imperial College London, UK.

• 2015-2018. Reader in Translational Systems Medicine, Imperial College London, UK.

• 2013-2015. Senior Lecturer in Translational Systems Biomedicine, Imperial College London, UK.

• 2009-2013. Lecturer in Systems Biomedicine, Imperial College London, UK.

• 2007-2009. Centre National de la Recherche Scientifique (CNRS): 1st class senior scientist (chargé de recherches 1ère classe) at Ecole Normale Supérieure de Lyon, France.

• 2006-2007. Wellcome Trust Research Fellow, Imperial College London, UK.

• 2002-2006. Wellcome Trust Research Associate, Imperial College London, UK.

Scientific summary

Marc-Emmanuel Dumas is a CNRS Director of Research, group leader and head of metabolomic platform IMPACT-PM at the European Genomic Institute for Diabetes (EGID), U1283 INSERM / UMR8199 CNRS in Lille, France and Director of the Imperial-University of Lille-CNRS International Research Project in Integrative Metabolism which launched in 2023. 

Research led by Marc-Emmanuel Dumas targets innovative metabolomics approaches to better understand the key challenges in the integrative control of metabolism, blending genomics and microbiomics in systems medicine. He focusses mostly on the role of the microbiome (but not limited to) in metabolic and cardiorespiratory diseases as well as in chronic inflammation, including neuroinflammation, and certain types of cancers.

Key Articles:

  1. Andrikopoulos P, Aron-Wisnewsky J, Chakaroun R, Myridakis A, Forslund SK, Nielsen T, Adriouch S, Holmes B, Chilloux J, Vieira-Silva S, Falony G, Salem JE, Andreelli F, Belda E, Kieswich J, Chechi K, Puig-Castellvi F, Chevalier M, Le Chatelier E, Olanipekun MT, Hoyles L, Alves R, Helft G, Isnard R, Køber L, Coelho LP, Rouault C, Gauguier D, Gøtze JP, Prifti E, Froguel P; MetaCardis Consortium; Zucker JD, Bäckhed F, Vestergaard H, Hansen T, Oppert JM, Blüher M, Nielsen J, Raes J, Bork P, Yaqoob MM, Stumvoll M, Pedersen O, Ehrlich SD, Clément K, Dumas ME*. Evidence of a causal and modifiable relationship between kidney function and circulating trimethylamine N-oxide. Nature Communications, 2023 Sep 20;14(1):5843. DOI: 10.1038/s41467-023-39824-4
  2. Puig Castellví F, Pacheco Tapia R, Deslande M, Jia M, Andrikopoulos P, Chechi K, Bonnefond A, Froguel P, Dumas ME*. Advances in the integration of metabolomics and metagenomics for human gut microbiome and their clinical applications. TrAC Trends in Analytical Chemistry, 2023, https://doi.org/10.1016/j.trac.2023.117248
  3. Jones RE, Gruszczyk AV, Schmidt C, Hammersley DJ, Mach L, Lee M, Wong J, Yang M, Hatipoglu S, Lota AS, Barnett SN, Toscano-Rivalta R, Owen R, Raja S, De Robertis F, Smail H, De-Souza A, Stock U, Kellman P, Griffin JL, Dumas ME, Martin JL, Saeb-Parsy K, Vazir A, Cleland JGF, Pennell DJ, Bhudia SK, Halliday BP, Noseda M, Frezza C, Murphy MP, Prasad SK. Assessment of left ventricular tissue mitochondrial bioenergetics in patients with stable coronary artery disease. Nature Cardiovascular Research 2023;2: 733–745. https://doi.org/10.1038/s44161-023-00312-z
  4. Pairo-Castineira E, Rawlik K, Bretherick AD, Qi T, Wu Y, Nassiri I, McConkey GA, Zechner M, Klaric L, Griffiths F, Oosthuyzen W, Kousathanas A, Richmond A, Millar J, Russell CD, Malinauskas T, Thwaites R, Morrice K, Keating S, Maslove D, Nichol A, Semple MG, Knight J, Shankar-Hari M, Summers C, Hinds C, Horby P, Ling L, McAuley D, Montgomery H, Openshaw PJM, Begg C, Walsh T, Tenesa A, Flores C, Riancho JA, Rojas-Martinez A, Lapunzina P; GenOMICC Investigators; SCOURGE Consortium; ISARIC4C Investigators; 23andMe COVID-19 Team; Yang J, Ponting CP, Wilson JF, Vitart V, Abedalthagafi M, Luchessi AD, Parra EJ, Cruz R, Carracedo A, Fawkes A, Murphy L, Rowan K, Pereira AC, Law A, Fairfax B, Hendry SC, Baillie JK. GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19. Nature. 2023 617(7962):764-768. doi: 10.1038/s41586-023-06034-3
  5. Serger E, Chadwick J, Luengo L, Kong G, Zhou L, Crawford G, Danzi M, Myridakis A, Brandis A, Bello A, Virgilis FD, Dumas ME, Strid J, Dodd D, Giovanni SD. The intermittent fasting-dependent gut microbial metabolite indole-3 propionate promotes nerve regeneration and recovery after injury. Nature. 2022;607(7919):585-592.
  6. Fromentin S, Forslund SK, Chechi K Aron-Wisnewsky J, Chakaroun R, Nielsen T, Tremaroli V, Ji B, Prifti E, Myridakis A, Chilloux J, Andrikopoulos P, Fan Yong, Olanipekun M, Alves R, Adiouch S, Bar N, Talmor-Barkan Y, Belda E, Caesar R, Coelho LP, Falony G, Fellahi S, Galan P, Galleron N, Helft G, Hoyles L, Isnard R, Le Chatelier E, Julienne H, Olsson L, Pedersen HK, Pons N, Quinquis B, Rouault C, Roume H, Salem JE, Schmidt TSB, Vieira-Silva S, Li P, Zimmermann-Kogadeeva M, Lewinter C, Søndertoft NB, Hansen TH, Gauguier D, Gøtze JP, Køber L, Kornowski R, Vestergaard H, Hansen T, Zucker JD, Hercberg S, Letunic I, Bäckhed F, Oppert JM, Nielsen J, Raes J, Bork P, Stumvoll M, Segal E, Clément K, Dumas ME*, Ehrlich SD*, Pedersen O*. Microbiome and metabolome in Ischaemic Heart Disease. Nature Medicine, 2022;28(2):303-314.
  7. Talmor-Barkan Y, Bar N, Shaul AA, Shachaf N, Godneva A, Lotan-Pompan M, Weinberger A, Shechter A, Chezar-Azerrad C, Aro Z, Hammer Y, Chechi K, Forslund SK, Fromentin S, Dumas ME, Ehrlich SD, Pedersen O, Kornowski R, Segal E. Metabolomic and microbiome profiling reveals personalized risk factors for coronary artery disease. Nature Medicine, 2022; 28(2):295-302.
  8. Menghini R, Hoyles L, Cardellini M, Casagrande V, Marino A, Gentileschi P, Davato F, Mavilio M, Arisi I, Mauriello A, Montanaro M, Scimeca M, Barton RH, Rappa F, Cappello F, Vinciguerra M, Moreno-Navarrete JM, Ricart W, Porzio O, Fernández-Real JM, Burcelin R, Dumas ME*, Federici M*. ITCH downregulation compromises hepatic degradation of branched-chain amino acids. Mol Met, 2022 Feb 9:101454. doi: 10.1016/j.molmet.2022.101454.
  9. Dejnirattisai W, Huo J, Zhou D, Zahradník J, Supasa P, Liu C, Duyvesteyn HME, Ginn HM, Mentzer AJ, Tuekprakhon A, Nutalai R, Wang B, Dijokaite A, Khan S, Avinoam O, Bahar M, Skelly D, Adele S, Johnson SA, Amini A, Ritter TG, Mason C, Dold C, Pan D, Assadi S, Bellass A, Omo-Dare N, Koeckerling D, Flaxman A, Jenkin D, Aley PK, Voysey M, Costa Clemens SA, Naveca FG, Nascimento V, Nascimento F, Fernandes da Costa C, Resende PC, Pauvolid-Correa A, Siqueira MM, Baillie V, Serafin N, Kwatra G, Da Silva K, Madhi SA, Nunes MC, Malik T, Openshaw PJM, Baillie JK, Semple MG, Townsend AR, Huang KA, Tan TK, Carroll MW, Klenerman P, Barnes E, Dunachie SJ, Constantinides B, Webster H, Crook D, Pollard AJ, Lambe T; OPTIC Consortium; ISARIC4C Consortium, Paterson NG, Williams MA, Hall DR, Fry EE, Mongkolsapaya J, Ren J, Schreiber G, Stuart DI, Screaton GR. SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses. Cell. 2022: S0092-8674(21)01578-6. doi: 10.1016/j.cell.2021.12.046.
  10. Belda E, Voland L, Tremaroli V, Falony G, Adriouch S, Assmann KE, Prifiti E, Aron-Wisnewsky J, Debédat J, Le Roy T, Nielsen T, Amouyal C, André S, Andreelli F, Blüher M, Chakaroun R, Chilloux J, Coelho LP, Dao MC, Das P, Fellahi S, Forslund S, Galleron N, Hansen TH, Holmes B, Ji B, Krogh Pedersen H, Le P, Le Chatelier E, Lewinter C, Mannerås-Holm L, Marquet F, Myridakis A, Pelloux V, Pons N, Quinquis B, Rouault C, Roume H, Salem JE, Sokolovska N, Søndertoft NB, Touch S, Vieira-Silva S; MetaCardis Consortium, Galan P, Holst J, Gøtze JP, Køber L, Vestergaard H, Hansen T, Hercberg S, Oppert JM, Nielsen J, Letunic I, Dumas ME, Stumvoll M, Pedersen OB, Bork P, Ehrlich SD, Zucker JD, Bäckhed F, Raes J, Clément K. Impairment of gut microbial biotin metabolism and host biotin status in severe obesity: effect of biotin and prebiotic supplementation on improved metabolism. Gut 2022: gutjnl-2021-325753. doi: 10.1136/gutjnl-2021-325753.
  11. Forslund S, Chakaroun R, Zimmermann-Kogadeeva M, Markó L, Aron-Wisnewsky J, Nielsen T, Moitinho-Silva L, Schmidt TS, Falony G, Vieira-Silva S, Adriouch S, Alves R, Assmann K, Bastard JP, Birkner T, Caesar R, Chilloux J, Coelho L, Fezeu L, Galleron N, Helft G, Isnard R, Ji B, Kuhn M, Le Chatelier E, Myridakis A, Olsson L, Pons N, Prifti E, Quinquis B, Roume H, Salem JE, Sokolovska N, Tremaroli V, Valles-Colomer M, Lewinter C, Sondertoft N, Krogh Pedersen H, Hansen H, The MetaCardis Consortium, Gøtze JP, Køber L, Vestergaard H, Hansen T, Zucker JD, Hercberg S, Oppert JM, Letunic I, Nielsen J, Bäckhed F, Ehrlich SD, Dumas ME, Raes J, Pedersen O, Clément K, Stumvoll M, Bork P. Combinatorial, additive and dose-dependent drug-microbiome associations. Nature 2021; 600(7889):500-505.
  12. COVID-19 Host Genetics Initiative, Mapping the human genetic architecture of COVID-19 Nature 2021;600(7889):472-477.
  13. Wickenhagen A, …, Wilson SJ; ISARIC4C Investigators. A prenylated dsRNA sensor protects against severe COVID-19. Science. 2021: 374(6567):eabj3624. doi: 10.1126/science.abj3624.
  14. Bermudez-Martin P, Becker JAJ, Caramello N, Fernandez SP, Costa-Campos R, Canaguier J, Barbosa S, Martinez-Gili L, Myridakis A, Dumas ME, Bruneau A, Cherbuy C, Langella P, Callebert J, Launay JM, Chabry J, Barik J, Le Merrer J, Glaichenhaus N, Davidovic L. The microbial metabolite p-Cresol induces autistic-like behaviors in mice by remodeling the gut microbiota. Microbiome 2021;9(1):157. 
  15. Drake TM, Riad AM, Fairfield CJ, Egan C, Knight SR, Pius R, Hardwick HE, Norman L, Shaw CA, McLean KA, Thompson AAR, Ho A, Swann OV, Sullivan M, Soares F, Holden KA, Merson L, Plotkin D, Sigfrid L, de Silva TI, Girvan M, Jackson C, Russell CD, Dunning J, Solomon T, Carson G, Olliaro P, Nguyen-Van-Tam JS, Turtle L, Docherty AB, Openshaw PJ, Baillie JK, Harrison EM, Semple MG; ISARIC4C investigators. Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study. Lancet 2021; 398(10296):223-237.
  16. Brial F, Chilloux J, Nielsen T, Vieira-Silva S, Falony G, Andrikopoulos P, Olanipekun M, Hoyles L, Neves AL, Rodriguez-Martinez A, Pons N, Forslund K, Le Chatelier E, Le Lay AM, Nicholson JK, Hansen T, METAHIT Consortium, Clement K, Bork P, Ehrlich SD, Raes J, Pedersen O, Gauguier D, Dumas ME*. Human and preclinical studies of the host-gut microbiome co-metabolite hippurate as a marker and mediator of metabolic health. Gut 2021;70(11):2105-2114. 
  17. Mayneris-Perxachs J, Cardellini M, Hoyles L, Latorre Luque J, Davato F, Moreno-Navarrete JM, Arnoriaga Rodríguez M, Serino M, Abbott J, Barton RH, Puig J, Fernández-Real X, Ricart W, Tomlinson C, Woodbridge M, Gentileschi P, Butcher S, Holmes E, Nicholson J, Pérez-Brocal V, Moya A, Mc Clain D, Burcelin R*, Dumas ME*, Federici M*, Fernandez-Real JM*. Unravelling the complex interplay between the gut microbiome and iron status in liver fat accumulation. Microbiome 2021;9(1):104. doi: 10.1186/s40168-021-01052-7.
  18. Molinaro A, Bel Lassen P, Henricsson M, Wu H, Adriouch S, Belda E, Chakaroun R, Nielsen T, Bergh PO, Rouault C, André S, Marquet F, Andreelli F, Salem JE, Assmann K, Bastard JP, Forslund S, Le Chatelier E, Falony G, Pons N, Prifti E, Quinquis B, Roume H, Vieira-Silva S, Hansen TH, Pedersen HK, Lewinter C, Sønderskov NB; MetaCardis Consortium, Køber L, Vestergaard H, Hansen T, Zucker JD, Galan P, Dumas ME, Raes J, Oppert JM, Letunic I, Nielsen J, Bork P, Ehrlich SD, Stumvoll M, Pedersen O, Aron-Wisneswky J, Clément K, Bäckhed F. Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology. Nature Communications 2020: 18;11(1):5881.
  19. Vieira-Silva S, Falony G, Belda E, Nielsen T, Assmann K, Forslund S, Aron-Wisnewsky J, Chakaroun R, Valles-Colomer M, Nguyen TTD, Prifti E, Tremaroli V, Pons N, Le Chatelier E, Andreelli F, Bastard JP, Coelho LP, Galleron N, Quinquis B, Rouault C, Roume H, Salem JE, Touch S, The MetaCardis Consortium, Dumas ME, Ehrlich SD, Hercberg S, Letunic I, Nielsen J, Oppert JM, Stumvoll M, Zucker JD, Bork P, Pedersen O, Backhed F, Clement K, Raes J. Statin treatment reduces the prevalence of gut microbiota dysbiosis in obese individuals. Nature 2020, 581(7808):310-315.
  20. Leboucher A, Pisani DF, Martinez-Gili L, Chilloux J, Bermudez-Martin P, Van Dijck A, Ganief T, Macek B, Becker JAJ, Le Merrer J, Kooy RF, Amri EZ, Khandjian EW, Dumas ME, Davidovic L. The translational regulator FMRP controls lipid and glucose metabolism in mice and humans. Mol Met 2019, pii: S2212-8778(18)31159-1.
  21. Hoyles L, Fernández-Real JM, Federici M, Serino M, Abbott J, Charpentier J, Heymes C, Latorre-Luque J, Anthony E, Rayah F, Chilloux J, Myridakis A, Martinez-Gili L, Moreno-Navarrete JM, Azalbert V, Blasco-Baque V, Barton RH, Puig J, Xifra G, Ricart W, Tomlinson C, Cardellini M, Davato F, Cardolini I, Porzio O, Gentilieschi P, Lopez F, Foufelle F, Butcher SA, Holmes E, Nicholson JK, Postic C, Burcelin R*, Dumas ME*. Molecular Phenomics and Metagenomics of Hepatic Steatosis in Non-Diabetic Obese Women. Nature Medicine, 2018;24(7):1070-1080.
  22. Hoyles L, Jimenez Pranteda ML, Chilloux J, Brial F, Myridakis A, Aranias T, Magnan C, Gibson GR, Sanderson JD, Nicholson JK, Gauguier D, McCartney AL*, Dumas ME*. Metabolic retroconversion of trimethylamine N-oxide and the gut microbiota. Microbiome, 2018;6(1):73.
  23. Plovier H, Everard A, Druart C, Depommier C, Van Hul M, Geurts L, Chilloux J, Ottman N, Duparc T, Lichtenstein L, Myridakis A, Delzenne NM, Klievink J, Bhattacharjee A, van der Ark KC, Aalvink S, Martinez LO, Dumas ME, Maiter D, Loumaye A, Hermans MP, Thissen JP, Belzer C, de Vos WM, Cani PD. A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice. Nature Medicine. 2017; 23(1):107-113.
  24. Dao MC, Everard A, Aron-Wisnewsky J, Sokolovska N, Prifti E, Chilloux J, Hoyles L, Verger EO, MICRO-Obes Consortium, Dumas ME, Rizkalla SW, Doré J, Cani PD, Clément K. Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology. Gut 2016; 65(3):426-36.
  25. Shoaie S, Ghaffari P, Kovatcheva-Datchary P, Mardinoglu A, Sen P, Pujos-Guillot E, de Wouters T, Juste C, Rizkalla S, Chilloux J, Hoyles L, Nicholson JK; MICRO-Obes Consortium, Doré J, Dumas ME, Clément K, Bäckhed F, Nielsen J. Quantifying diet induced changes in amino acid metabolism of the human gut microbiome. Cell Metab. 2015; 22(2):320-331.
  26. Venkatesh M, Mukherjee S Wang H, Li H, Sun K, Benechet AP, Qiu Z, Maher L, Redinbo MR, Phillips RS, Fleet JC, Kortagere S, Mukherjee P, Fasano A, Le Ven J, Nicholson JK, Dumas ME, Khanna KM, Mani S. Symbiotic Bacterial Metabolites Regulate GI Barrier Function via PXR and TLR4. Immunity, 2014; 41(2):296–310.
  27. Dumas ME*, Kinross J, Nicholson JK. Metabolic phenotyping and systems biology to understanding the metabolic syndrome and fatty liver disease. Gastroenterology. 2014; 146(1):46-62.
  28. Davidovic L, Navratil V, Bonaccorso CM, Catania MV, Bardoni B, Dumas ME*. A Metabolomic and Systems Biology Perspective of Fragile X Syndrome in The Mouse. Genome Res, 2011;21(12):2190-2202.
  29. Blaise BJ, Giacomotto, J, Elena B, Dumas ME, Toulhoat P, Segalat L, Emsley L. Metabotyping of Caenorhabditis elegans reveals latent phenotypes. Proc. Natl. Acad. Sci. USA. 2007; 104:19808-12. Faculty of 1000 Biology FFa=10, listed as “hidden jewel”. 
  30. Dumas ME, Wilder SP, Bihoreau MT, Barton R, Fearnside J, Argoud K, D’Amato L, Wallis RH, Blancher C, Keun HC, Baunsgaard D, Scott J, Sidelmann UG, Nicholson JK, Gauguier D. Direct quantitative trait locus mapping of mammalian phenotypes in diabetic and normoglycemic rat models. Nature Genetics. 2007; 39: 666-672. 
  31. Dumas ME*, Barton R, Toye A, Cloarec O, Blancher C, Rothwell A, Fearnside J, Tatoud R, Blanc V, Lindon J, Mitchell SV, Holmes E, McCarthy MI, Scott J, Gauguier D, and Nicholson J* Metabolic profiling reveals a contribution of gut microbiota to dietary-induced fatty liver phenotype in mice. Proc. Natl. Acad. Sci. USA, 2006; 103:12511-12516. 
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