Scientific topics
Keywords
ITMO
Bruno Mesmin PhD.
Course and current status
- Current position
Chargé de Recherche (CRCN) Inserm. Institut de Pharmacologie Moléculaire et Cellulaire, CNRS UMR 7275, Université Côte d’Azur. Valbonne Sophia-Antipolis, France
- Education and Degrees
2021 HDR (Habilitation to conduct research), Université Côte d’Azur
2007 Doctorate (PhD.) in Cellular and Molecular Biology with honors, Université Côte d’Azur
2004 Master of Advanced Studies (DEA) in Cellular and Molecular Biology with honors, Université Côte d’Azur
- Scientific Career
2014-present Tenured research scientist (CRCN) Inserm, IPMC, CNRS UMR 7275
2011-2014 Post-doctorate, IPMC, CNRS UMR 7275
2008-2011 Post-doctorate, Weill Cornell Medicine, New York, USA
2004-2007 Doctorate and Teaching assistant, CNRS UMR 7275, Université Côte d’Azur
- Grants and Awards
2023 PEPR/MIE France 2030 grant (ANRS-23-PEPR-MIE 0004)
2021 ANR grant (Coordinator; ANR-21-CE13-0021-01)
2018 Université Côte d’Azur Excellence Award
2018 Journal of Lipid Research Junior Investigator Award
2015 ANR grant (ANR-15-CE11-0027-02)
2014 Alpes Maritimes Department's call for health projects grant
2008 GERLI (French Lipidomics Group) PhD thesis Prize
2007 Fondation pour la Recherche Médicale (FRM) research grant
2004 PhD thesis grant from the Ministry of Higher Education and Reseach.
- Research expertise
Membrane biology, lipid and membrane transport, lipid metabolism and associated diseases, membrane contact sites, protein-membrane interactions and membrane remodeling. Live cell imaging, wide field, confocal, STED microscopy. Biochemistry, fluorescence spectroscopy, in vitro reconstitution. Liposomes. Protein production and purification, HPLC. Molecular biology, cloning, mutagenesis, CRISPR-Cas9.
ReseacherID: N-9246-2017
ORCID: 0000-0002-5437-3246
Keywords: Cholesterol, phosphoinositides, organelles, lipid trafficking, lipid metabolism, lipid transfer proteins, membrane contact sites, Golgi, Endoplasmic reticulum
- Expertise activities
Grant reviewing activities: ANR, Swiss National Science Foundation, Université Paris Cité
Reviewing for international journals: EMBO journal, Current Opinion in Cell Biology, Frontiers in Cell and Developmental Biology, Molecular and Cellular Endocrinology, Nature Communication, Cellular and Molecular Life Sciences, Scientific Reports, Science Advances, Contact, Biology of the Cell, The Journal of Cell Biology, eLife, Plos One, International Journal of Molecular Sciences, FEBS Letters, Cell, Biochemistry
Editorial Board member: Contact
Guest Editor for Special Issues: International Journal of Molecular Sciences, Contact
Jury member: 7 Thesis juries, 1 HDR jury
- Teaching and training
Supervision of 3 PhD students, 2 PhD students for short internship, 2 engineers, 4 Master students, 3 engineering students.
Teaching at Université Côte d'Azur in the Life Science Master's program, and at Polytech Nice School of Engineering in Biology.
- Scientific communication
Invited talks:
2023 4th Endoplasmic Reticulum International Symposium. Paris, France
2023 Seminar at MMDN, Univ Montpellier, France
2022 EMBO workshop. Inositol lipids. Bangalore, India
2022 Ecole Thématique Métabiodivex. Aussois, France
2021 Ara Parseghian symposium on NPC disease. Tucson, USA
2018 59th International Conference on the Bioscience of Lipids. Helsinki, Finland
2017 Seminar at Institut Curie. Paris, France
2016 Sphingonet's International Colloquium. Amsterdam, The Netherlands
2014 International Symposium of the SFB 635. Cologne, Germany
2014 CoReBio PACA scientific meeting. Marseille, France
2014 Seminar at Institut Jacques Monod. Paris, France
Talks selected on abstract:
2019 ASCB/EMBO Annual Meeting. Washington DC, USA.
2017 ASBMB Annual Meeting. Chicago, USA
2014 SBCF Meeting. Building the Cell. Paris, France
2014 ASCB Annual Meeting. Philadelphia, USA
2011 ASBMB Special Symposium. Snowbird, USA
2008 Congrès du GERLI. Les Lipides du Futur. Compiègne, France
2007 FEBS-EMBO Advanced Course. Cargèse, France
Poster presentations:
2022 EMBO workshop. The endoplasmic reticulum meeting. Lucca, Italie
2013 Gordon Research Conference: Molecular Membrane Biology. Andover, USA
2012 The EMBO meeting. Nice, France
2010 ASCB Annual Meeting. Philadelphia, USA
2006 FEBS Special Meeting, New Concepts in Lipidology. Noordwijkerhout, The Netherlands
Scientific summary
My scientific interests are membrane biology and lipid transport. I worked on intracellular cholesterol transport and sterol transfer proteins both with Frederick R. Maxfield during my postdoc and with Bruno Antonny. We have established a new model for non-vesicular lipid traffic at membrane contact sites, in which forward lipid transport is coupled to backward transport and hydrolysis of the phosphoinositide PI(4)P. I was hired Chargé de Recherche by Inserm in 2014 and received the HDR in 2021. The central focus of my current research is the structure and function of proteins involved in organelles contacts and the associated membrane dynamics and signaling.
