Bruno Mesmin
  • E-mail :[email]
  • Phone : +33 4 93 95 77 67
  • Location : Valbonne Sophia-Antipolis, France
Last update 2023-03-14 18:54:04.592

Bruno Mesmin PhD.

Course and current status

  • Current position

Chargé de Recherche (CRCN) Inserm. Institut de Pharmacologie Moléculaire et Cellulaire, CNRS UMR 7275, Université Côte d’Azur. Valbonne Sophia-Antipolis, France


  • Education and Degrees

2021              HDR (Habilitation to conduct research), Université Côte d’Azur

2007              Doctorate (PhD.) in Cellular and Molecular Biology with honors, Université Côte d’Azur

2004              Master of Advanced Studies (DEA) in Cellular and Molecular Biology with honors, Université Côte d’Azur


  • Scientific Career

2014-present Research scientist (CRCN) Inserm, IPMC, CNRS UMR 7275

2011-2014     Research scientist, IPMC, CNRS UMR 7275

2008-2011     Post-doctorate, Weill Cornell Medicine, New York, USA

2004-2007     Doctorate and Teaching assistant, CNRS UMR 7275, Université Côte d’Azur


  • Grants and Awards

2021              ANR grant (Coordinator; ANR-21-CE13-0021-01)

2018              Université Côte d’Azur Excellence Award

2018              Journal of Lipid Research Junior Investigator Award

2015              ANR grant (Scientific partner; ANR-15-CE11-0027-02)

2014              Alpes Maritimes Department's call for health projects grant

2008              GERLI (French Lipidomics Group) PhD thesis Prize

2007              Fondation pour la Recherche Médicale (FRM) research grant

2004              PhD thesis grant from the Ministry of Higher Education and Reseach.


  •  Research expertise  

Membrane biology, lipid and membrane transport, lipid metabolism and associated diseases, membrane contact sites, protein-membrane interactions and membrane remodeling. Live cell imaging, wide field, confocal, STED microscopy. Biochemistry, fluorescence spectroscopy, in vitro reconstitution. Liposomes. Protein production and purification, HPLC. Molecular biology, cloning, mutagenesis, CRISPR-Cas9.

ReseacherID: N-9246-2017

ORCID: 0000-0002-5437-3246 

Keywords: Cholesterol, phosphoinositides, organelles, lipid trafficking, lipid metabolism, lipid transfer proteins, membrane contact sites, Golgi, Endoplasmic reticulum


  • Expertise activities

Grant reviewing activities: ANR, Swiss National Science Foundation, Université Paris Cité

Reviewing for international journals: EMBO journal, Current Opinion in Cell Biology, Frontiers in Cell and Developmental Biology, Molecular and Cellular Endocrinology, Nature Communication, Cellular and Molecular Life Sciences, Scientific Reports, Science Advances, Contact, Biology of the Cell, The Journal of Cell Biology, eLife, Plos One, International Journal of Molecular Sciences, FEBS Letters

Editorial Board member: Contact

Guest Editor for Special Issues: International Journal of Molecular Sciences, Contact

Jury member: 2 Thesis juries, 1 HDR jury, 2 Thesis follow-up committees, 4 Master-1, 2 Master-2 juries, 6 Biological Engineering School juries.

Other expertise: Member of the steering committee of MICA (Microscopy Imaging Côte d'Azur)


  • Teaching and training

Supervision of 2 PhD students, 2 PhD students for short internship, 2 engineers, 4 Master students, 3 engineering students, 1 BTS student

Recurrent teaching at Université Côte d'Azur in the Life Science Master's program UE Life Imaging; and at Polytech Nice School of Engineering in Biology, in the Integrative Biology module

  • Scientific communication

Invited talks: 

2023               4th Endoplasmic Reticulum International Symposium. Paris, France

2023               Seminar at MMDN, Univ Montpellier, France

2022               EMBO workshop. Inositol lipids. Bangalore, India

2022               Ecole Thématique Métabiodivex. Aussois, France  

2021               Ara Parseghian symposium on NPC disease. Tucson, USA

2018               59th International Conference on the Bioscience of Lipids. Helsinki, Finland

2017               Seminar at Institut Curie. Paris, France

2016               Sphingonet's International Colloquium. Amsterdam, The Netherlands

2014               International Symposium of the SFB 635. Cologne, Germany

2014               CoReBio PACA scientific meeting. Marseille, France

2014               Seminar at Institut Jacques Monod. Paris, France

Talks selected on abstract:

2019               ASCB/EMBO Annual Meeting. Washington DC, USA.

2017               ASBMB Annual Meeting. Chicago, USA

2014               SBCF Meeting. Building the Cell. Paris, France

2014               ASCB Annual Meeting. Philadelphia, USA

2011               ASBMB Special Symposium. Snowbird, USA

2008               Congrès du GERLI. Les Lipides du Futur. Compiègne, France

2007               FEBS-EMBO Advanced Course. Cargèse, France

Poster presentations:

2022               EMBO workshop. The endoplasmic reticulum meeting. Lucca, Italie

2013               Gordon Research Conference: Molecular Membrane Biology. Andover, USA

2012               The EMBO meeting. Nice, France

2010               ASCB Annual Meeting. Philadelphia, USA

2006               FEBS Special Meeting, New Concepts in Lipidology. Noordwijkerhout, The Netherlands

Scientific summary

My scientific interests are membrane biology and lipid transport. I worked on intracellular cholesterol transport and sterol transfer proteins both with Frederick R. Maxfield during my postdoc and with Bruno Antonny. We have established a new model for non-vesicular lipid traffic at membrane contact sites, in which forward lipid transport is coupled to backward transport and hydrolysis of the phosphoinositide PI(4)P. I was hired Chargé de Recherche by Inserm in 2014 and received the HDR in 2021. The central focus of my current research is the structure and function of proteins involved in organelles contacts and the associated membrane dynamics and signaling.

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