CV Science

Fabrice Lejeune Research Director, Inserm, PhD

Course and current status

ACADEMIC QUALIFICATIONS

Present: Team Leader (Molecular therapeutical approaches for genetic diseases and cancers – U1277 Inserm/UMR9020 CNRS) at Oncolille

Deember 2012 – August 2022: Researcher in Dr. David Tulasne group (UMR 9020 CNRS - UMR 1277 Inserm: CANcer Heterogeneity, Plasticity and Resistance to THERapies) at Institut de Biologie de Lille: correction of nonsense mutations in genetic diseases

January 2008 – December 2012: Leader of an AVENIR team (INSERM) at Pasteur Institute of Lille (France): correction of nonsense mutations in genetic diseases

April 2008 – Certificate for the capacity in managing PhD student

December 2005-December 2007: Assistant Professor Researcher in Pr. Jamal Tazi lab at the IGM Montpellier (France)

Study of Nonsense-mediated mRNA decay regulations        

February 2005- December 2005: Post doc fellow in Pr. Jamal Tazi lab at the IGM Montpellier (France)

Study of Nonsense-mediated mRNA decay regulations

August 2001- January 2005: Post-doc fellow at the University of Rochester (with Pr. Maquat L.E.)

Study of Nonsense-mediated mRNA decay mechanism

July 2001: PhD at the Institute of Genetics and Molecular and Cellular Biology (Supervised by Dr. James Stévenin)

"Studies of the alternative splicing regulation of the 9G8 intron 3 and consequences on the 9G8 SR protein expression".

Scientific summary

Our research focuses on the study of the mechanisms of recognition of premature termination codons and on the identification and characterization of correctors of nonsense mutations for the development of new therapeutic approaches in genetic diseases.