• E-mail :[email]
  • Phone : 04 73 17 81 82
  • Location : Clermont-Ferrand, France
Last update 2012-06-13 12:51:52.638

Silke Jensen PhD Cellular and Molecular Genetics, HDR

Course and current status

1982 :             Abitur, in Flensburg, Germany

1982/83 :        "Cours de Civilisation Française", University Sorbonne, Paris, France

1983-85 :        DEUG "Sciences de la Nature et de la Vie", University Paris 7

1985-88 :        "Magistère de Biologie-Biochimie", of Universities Paris 6, Paris 7, Paris 11

                                          and Ecoles Normales Supérieures

1988-93 :        PhD Cellular and Molecular Genetics, University Paris 6

1993-95 :        post-doctoral position

1995-today :   "Chargé de Recherche" at the CNRS

                       degre : 1995: CR2, 1999: CR1

2004 :             "Habilitation à Diriger des Recherches", University René Descartes Paris 5


1988-2008      CNRS URA 147, Institut G. Roussy, 94805 Villejuif, France

                        Director : Dr. Thierry Heidmann

2008-today     GReD, CNRS UMR 6293, INSERM U1103, Clermont University

                       Faculty of Medecine, 63001 Clermont-Ferrand, France

                       Director: Dr. Chantal Vaury

Scientific summary

The activity of mobile genetic elements is highly mutagenic and involved in severe pathologies in Human. Thus, it is essential for an organism to control transposons. The Drosophila I element, a transposon similar to human LINEs, gives us an excellent model to study the mechanisms of this regulation. I element activity is repressed by an epigenetic process which is homology-dependent and linked to RNA interference. Fragments of the I element, even non-coding but necessarily transcribed, introduced into drosophila by transgenesis are able to repress transposition of functional I elements, in a sort of genetic vaccination. Remnants of ancient invasions by I, called I-RE, play an essential role in this regulation. The aim of our research is to understand how regulation of I elements is achieved at the molecular level.

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