CV Science

Sarah Guimbal The neurovascular unit in the context of Multiple Sclerosis.

Course and current status

09/2025-present       Postdoctoral researcher in Biology/Health

Inserm U1034, Biology of cardiovascular diseases, Pessac, France

04/2021-08/2025           Postdoctoral researcher in Biology/Health

Theodor Kocher Institut, Universtity of Bern, Bern  Switzerland.    

11/2017-12/2020           PhD student in Biology/Health

Inserm U1034, Biology of cardiovascular diseases, Pessac, France          

Scientific summary

While it is now established that blood-brain barrier (BBB) breakdown allows for immune cell entry into PVS and subarachnoid space (SAS) during central nervous system (CNS) immune surveillance and promotes immune cell infiltration into the PVS during neuropathology, the role of astrocytes appears more ambivalent.

Thus, it is of relevance to understand the mechanisms underlying the astrocyte-immune cell interaction during neuroinflammation.

Unveiling the signals regulating astrocyte and immune cell dialogue in the context of neuroinflammation will improve our understanding of mechanisms contributing to MS pathogenesis.