Scientific topics
Keywords
ITMO
Sarah Guimbal The neurovascular unit in the context of Multiple Sclerosis.
Course and current status
09/2025-present Postdoctoral researcher in Biology/Health
Inserm U1034, Biology of cardiovascular diseases, Pessac, France
04/2021-08/2025 Postdoctoral researcher in Biology/Health
Theodor Kocher Institut, Universtity of Bern, Bern Switzerland.
11/2017-12/2020 PhD student in Biology/Health
Inserm U1034 unit, cardiovascular adaptation to ischemia, Bordeaux, France
Scientific summary
While it is now established that blood-brain barrier (BBB) breakdown allows for immune cell entry into PVS and subarachnoid space (SAS) during central nervous system (CNS) immune surveillance and promotes immune cell infiltration into the PVS during neuropathology, the role of astrocytes appears more ambivalent.
Thus, it is of relevance to understand the mechanisms underlying the astrocyte-immune cell interaction during neuroinflammation.
Unveiling the signals regulating astrocyte and immune cell dialogue in the context of neuroinflammation will improve our understanding of mechanisms contributing to MS pathogenesis.
