CV Science

Valérie Lamour PhD Structural Biology

Course and current status

 

Research positions 

Since 2014:  Team leader, IGBMC: Chromatin stability and DNA mobility- Integrated Structural Biology Department

2008-2018: Marie Curie International Reintegration Grant fellow -IGBMC, Strasbourg, France

Since 2009 : Associate Professor, IGBMC-Strasbourg University Hospitals (MCU-PH class 1)

2003-2008: Postdoctoral fellow, The Rockefeller University, New York, USA

Structural studies of Bacterial RNA polymerase complexes

2000-2003: Postdoctoral associate, IGBMC, Strasbourg France

Thermus DNA topoisomerases structural studies

Academic responsabilities

Since 2021: Deputy Vice-President for Research, in charge of Life Sciences and Health, Strasbourg University

2017-2020: Deputy Vice-President for Research, in charge of Interdisciplinarity, Strasbourg University

Since 2016: President of the French national network of MD-PhD programs

Since 2013: Coordinator of Strasbourg University MD-PhD programme, Strasbourg Uiversity Initiative of Excellence

 

Training and diplomas

2011 : Habilitation for Research Direction   (HDR), Strasbourg University 

1999: PhD Structural Biology, Strasbourg University, France

Structural studies of human transcription/repair factors- IGBMC

1995: DEA in Biological NMR and Crystallography, Strasbourg University, France

1994: Chemical Engineer degree, EHICS Strasbourg France

Scientific summary

V. Lamour has joined the IGBMC Integrative Structural Biology Department in 2008 through a Marie Curie International Reintegration grant (FP7). Her research project is aiming at the functional and structural studies of human DNA topoisomerase 2 (Top2) complexes targeted by therapeutic compounds used in cancer treatment. The goal of this study is to identify and study the architecture of Top2-associated complexes targeted by anti-cancer drugs through a combination of biochemical and structural approaches.Since 2014, V. Lamour is co-directing the IGBMC team "Chromatin stability and DNA mobility" with  M. Ruff who focuses on HIV integration complexes. The team uses a combination of structural techniques such as in solution biophysical methods, cryo-electron microscopy, x-ray crystallography with biochemistry and proteomic techniques to address biomedical relevant questions.

The Integrative Structural Biology Department offers state-of-the-art structural biology equipments and access to scientific platforms within the IGBMC. The department is one of the two French nodes for the european infrastructure in structural Biology INSTRUCT-ERIC and coordinator of the french infrastructure FRISBI  for structural biology.

V. Lamour is the coordinator of Strasbourg University MD-PhD Idex program since 2013 and  Deputy Vice-President for Research of Strasbourg University, in charge of Life Sciences and health since March 2021.

 

The Topo project members

Valerie Lamour, associate professor (MCU-PH, coordinator)

Viola Mazzoleni, assistant professor (MCU)

Philippe Ramain, researcher (DR CNRS)

Robert Drillien, researcher (DR Inserm émérite)

Marlène Vayssières, postdoc

Brian Lopez (PhD student)

Vita Vidmar, PhD student (co-direction with A. Weixlbaumer's team, IGBMC)

 

Education

Nina Prats-Torne, MD-PhD administrative assistant  

Former Members of the Topo project:

Léa Haas, Master student and research engineer 2020-2021

Loup Petit, Master student 2021

Christophe Lotz,  PhD student 2017-2020

Arnaud Vanden Broeck, PhD student 2015-2018

Claire Bedez, PhD student 2011-2015

Morgane Gilg, Master student 2015

Claire Batisse, research engineer 2012-2014

Pélagie Fichter, Master student 2013

Geoffrey Gourinchas, Master student 2013

Julie Papillon, PhD student 2008-2012

Albin Simoni, research engineer 2010

The HIV project members :

Marc Ruff (coordinator)

Julien Batisse (assistant professor)

Rui Zhu (PhD student)

Nicolas Levy (research collaborator)

Robert Drillien (researcher)

Sylvia Eiler (engineer)

Sylvie Duclaud (technician)