Scientific topics
Keywords
ITMO
Valérie Lamour PhD Structural Biology
Course and current status
Research positions
Since 2024: Team leader, IGBMC: Regulation of DNA topology, Integrated Structural Biology Department
Since 2014: co-Team leader, IGBMC: Chromatin stability and DNA mobility- Integrated Structural Biology Department
2008-2018: Marie Curie International Reintegration Grant fellow -IGBMC, Strasbourg, France
Since 2009 : Associate Professor, IGBMC-Strasbourg University Hospitals (Faculty of Medicine, MCU-PH class 1)
2003-2008: Postdoctoral fellow, The Rockefeller University, New York, USA
Structural studies of Bacterial RNA polymerase complexes
2000-2003: Postdoctoral associate, IGBMC, Strasbourg France
Thermus DNA topoisomerases structural studies
Academic responsabilities
Since 2021: Deputy Vice-President for Research, in charge of Life Sciences and Health, Strasbourg University
2017-2020: Deputy Vice-President for Research, in charge of Interdisciplinarity, Strasbourg University
Since 2016: President of the French national network of MD-PhD programmes
Since 2013: Coordinator of Strasbourg University MD-PhD programme, Strasbourg Uiversity Initiative of Excellence
Training and diplomas
2011 : Habilitation for Research Direction (HDR), Strasbourg University
1999: PhD Structural Biology, Strasbourg University, France
Structural studies of human transcription/repair factors- IGBMC
1995: Master's degree in Biological NMR and Crystallography (DEA national), Strasbourg University, France
1994: Chemical Engineer degree, EHICS Strasbourg France
Scientific summary
V. Lamour has joined the Integrative Structural Biology Department at IGBMC (Strasbourg, France) in 2008 through a Marie Curie International Reintegration grant (FP7). Her research project is aiming at the functional and structural studies of bacterial and human DNA topoisomerase 2 (TopoII) nucleoprotein complexes.
Since 2014, V. Lamour was co-directing the team "Chromatin stability and DNA mobility" with 2 main projects: the regulation of DNA topology, and HIV integration complexes (project led by Dr Marc Ruff). Since 2024, V. Lamour is now directing the Team renamed and primarly focused on the "Regulation of DNA topology" as recognized by Inserm, CNRS and University of Strasbourg (2024-2028).
Our main goal is to identify and study the architecture of TopoII-associated complexes targeted by therapeutic compounds through a combination of biochemical and structural approaches. We are also interested in the interactions between DNA topology and transcription machineries, in collaboration with the team of Albert Weixlbaumer at IGBMC.
Our team uses a combination of structural techniques such as in solution biophysical methods, cryo-electron microscopy, x-ray crystallography, combined with biochemistry and proteomic techniques to address biomedical relevant questions.
The Integrative Structural Biology Department offers state-of-the-art structural biology equipments and access to scientific platforms within the IGBMC. The department is one of the two French nodes for the european infrastructure in structural Biology INSTRUCT-ERIC and coordinator of the french infrastructure FRISBI for structural biology.
V. Lamour is the coordinator of Strasbourg University MD-PhD Idex programme since 2013 and Deputy Vice-President for Research of Strasbourg University, in charge of the Life Sciences and Health sector since March 2021.
Relevant links to publications at the bottom of this page:
The Topo project members
Valerie Lamour, associate professor (MCU-PH, coordinator)
Viola Mazzoleni, assistant professor (MCU)
Luc Bonnefond, assistant professor (MCU)
Philippe Ramain, senior researcher (DR CNRS)
Amélie Boichard, clinician assistant professor (MCU-PH)
Naveen Murugasamy, PhD student
Brian Lopez Duran, PhD student
Education
Nina Prats-Torne, MD-PhD administrative assistant
Former Members of the Topo project:
Vita Vidmar, PhD student 2020-2024
Robert Drillien, emeritus researcher (DR Inserm émérite)
Marlène Vayssières, Postdoc 2020-2022
Léa Haas, Master 2 student and research engineer 2020-2021
Loup Petit, ESBS engineering school student 2021
Lucas Dubs, Master 1 student 2021
Fabien Flieg, Licence 3 student 2020
Christophe Lotz, PhD student 2017-2020
Arnaud Vanden Broeck, PhD student 2015-2018
Claire Bedez, PhD student 2011-2015
Morgane Gilg, Master student 2015
Claire Batisse, research engineer 2012-2014
Pélagie Fichter, Master student 2013
Geoffrey Gourinchas, Master student 2013
Julie Papillon, PhD student 2008-2012
Albin Simoni, research engineer 2010
The HIV project members :
Marc Ruff (coordinator)
Julien Batisse (assistant professor)
Yuri Zgazday (Postdoc)
Nicolas Levy (research collaborator)
Sylvia Eiler (engineer)
Sylvie Duclaud (technician)
