Valérie Lamour
  • E-mail :[email]
  • Phone : +33 3 88 69 48 52 81
  • Location : Strasbourg, France
Last update 2023-04-18 15:07:35.314

Valérie Lamour PhD Structural Biology

Course and current status


Research positions 

Since 2014:  Team leader, IGBMC: Chromatin stability and DNA mobility- Integrated Structural Biology Department

2008-2018Marie Curie International Reintegration Grant fellow -IGBMC, Strasbourg, France

Since 2009 : Associate Professor, IGBMC-Strasbourg University Hospitals (Faculty of Medicine, MCU-PH class 1)

2003-2008: Postdoctoral fellow, The Rockefeller University, New York, USA

Structural studies of Bacterial RNA polymerase complexes

2000-2003: Postdoctoral associate, IGBMC, Strasbourg France

Thermus DNA topoisomerases structural studies

Academic responsabilities

Since 2021Deputy Vice-President for Research, in charge of Life Sciences and Health, Strasbourg University 

2017-2020: Deputy Vice-President for Research, in charge of Interdisciplinarity, Strasbourg University

Since 2016: President of the French national network of MD-PhD programmes

Since 2013: Coordinator of Strasbourg University MD-PhD programme, Strasbourg Uiversity Initiative of Excellence

Link (in french)

Training and diplomas

2011 Habilitation for Research Direction (HDR), Strasbourg University 

1999: PhD Structural Biology, Strasbourg University, France

Structural studies of human transcription/repair factors- IGBMC

1995: Master's degree in Biological NMR and Crystallography (DEA national), Strasbourg University, France

1994: Chemical Engineer degree, EHICS Strasbourg France

Scientific summary

V. Lamour has joined the Integrative Structural Biology Department at IGBMC (Strasbourg, France) in 2008 through a Marie Curie International Reintegration grant (FP7). Her research project is aiming at the functional and structural studies of bacterial and human DNA topoisomerase 2 (Topo2) nucleoprotein complexes.

Since 2014, V. Lamour is co-directing the team "Chromatin stability and DNA mobility" with 2 main projects: the regulation of DNA topology, and HIV integration complexes (project led by Dr Marc Ruff). 

Our main goal is to identify and study the architecture of Topo2-associated complexes targeted by therapeutic compounds  through a combination of biochemical and structural approaches. We are also interested in the interactions between DNA topology and transcription machineries, in collaboration with the team of Albert Weixlbaumer at IGBMC.

Our team uses a combination of structural techniques such as in solution biophysical methods, cryo-electron microscopy, x-ray crystallography, combined with biochemistry and proteomic techniques to address biomedical relevant questions.

The Integrative Structural Biology Department offers state-of-the-art structural biology equipments and access to scientific platforms within the IGBMC. The department is one of the two French nodes for the european infrastructure in structural Biology INSTRUCT-ERIC and coordinator of the french infrastructure FRISBI  for structural biology.

V. Lamour is the coordinator of Strasbourg University MD-PhD Idex programme since 2013 and  Deputy Vice-President for Research of Strasbourg University, in charge of the Life Sciences and Health sector since March 2021.

 Relevant links to publications at the bottom of this page:

IGBMC Topo webpage

The Topo project members

Valerie Lamour, associate professor (MCU-PH, coordinator)

Viola Mazzoleni, lecturer (MCU)

Philippe Ramain, senior researcher (DR CNRS)

Robert Drillien, emeritus researcher (DR Inserm émérite)

Naveen Murugasamy, PhD student

Brian Lopez Duran, PhD student

Vita Vidmar, PhD student (co-direction with A. Weixlbaumer's team, IGBMC)



Nina Prats-Torne, MD-PhD administrative assistant  

Former Members of the Topo project:

Marlène Vayssières, Postdoc 2020-2022 

Léa Haas, Master 2 student and research engineer 2020-2021

Loup Petit, ESBS engineering school student 2021 

Lucas Dubs, Master 1 student 2021

Fabien Flieg, Licence 3 student 2020

Christophe Lotz,  PhD student 2017-2020

Arnaud Vanden Broeck, PhD student 2015-2018

Claire Bedez, PhD student 2011-2015

Morgane Gilg, Master student 2015

Claire Batisse, research engineer 2012-2014

Pélagie Fichter, Master student 2013

Geoffrey Gourinchas, Master student 2013

Julie Papillon, PhD student 2008-2012

Albin Simoni, research engineer 2010

The HIV project members :

Marc Ruff (coordinator)

Julien Batisse (assistant professor)

Rui Zhu (PhD student)

Lisa Wekler (PhD student)

Nicolas Levy (research collaborator)

Robert Drillien (researcher)

Sylvia Eiler (engineer)

Sylvie Duclaud (technician)




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