CV Science

Yves Gaudin PhD Biochemistry

Course and current status

Yves Gaudin (47 years old)

Current position

• CNRS group leader (Research Director, 1st class)
• Head of the “Laboratoire de Virologie Moléculaire et Structurale” (UPR-CNRS 3296, Gif sur Yvette)

Degrees and diplomas

• "Habilitation à diriger des recherches" (November 1999).
• PhD in Biochemistry, University of Paris VII (June 1992).
• Master (DEA) of Biochemistry, University of Paris VII (September 1989).
• Engineer of the Ecole Polytechnique, Palaiseau, (Diploma obtained in July 1988).

Research

• 2005-present: Director of the "Laboratoire de Virologie Moléculaire et Structurale", Gif sur Yvette, France.
• 1999-present: Co-leader of the group "Structure and functions of the rhabdovirus proteins" in the "Laboratoire de Virologie Moléculaire et Structurale", Gif sur Yvette, France.
• 1993-1999: CNRS Staff scientist in the "Laboratoire de Génétique des Virus", Gif sur Yvette, France. PI : Anne Flamand.
• 1992-1993: Post-doctoral fellow in the "Laboratoire de Génétique des Virus", Gif sur Yvette, France. PI : Anne Flamand.
• 1989-1992: PhD Student in Biochemistry and Virology. University Paris VII. "Laboratoire de Génétique des Virus", Gif sur Yvette, France. PI Anne Flamand.

Publications

• 46 publications referenced in PubMed since 1991. 32 as first, last and/or corresponding author.
• Number of citations: 1847, H factor: 27 (WOS)

Supervision of students and postdocs since 1997

• 6 PhD students: one have been recruited by the CNRS, one by the CEA, one by a private company, one is a post doc, two are still in the team.
• 2 post-docs: one has been recruited by a private company, the other is still in the team.

Research contracts since 1997

• 10 research contracts.
• 9 as coordinator among which 3 from the ANR and one from the FRM.
• Partner of an EU ITN "Virus entry" (7th PCRD).

Principal invited conferences since 2007

• Gordon Research Conference "Cell-cell fusion" (Colby-Sawyer College, New London, USA, 1-6 July, 2007).
• Keystone symposium "Cell Biology of Virus Entry, Replication and Pathogenesis" (Victoria, Canada, 13-18 April, 2008).
• XIV International Congress of Virology (Plenary session)(Istambul, Turkey, 10-15 August, 2008).
• Gordon Research Conference "Viruses and cells" (Il Ciocco, Italy, 7-12 June, 2009).
• 3rd International biomedical Research meeting (Résidence de Marigny, Paris, June 11, 2011)
• Gordon Research Conference "Cell-cell fusion" (University of New England, Biddeford, USA, 7-12 August, 2011).
• Seventh International Virus Assembly Symposium, Menorca, Spain, 13-17 May 2012)

Scientific summary

Research Topics and Scientific interests

• Structural studies on rhabdovirus proteins: Determination of the structures of the matrix protein and of the glycoprotein of vesicular stomatitis virus (VSV).

• Mechanism of viral membrane fusion: Highlighting the specificities of the fusion machinery of rhabdoviruses, characterization of fusion intermediates.

• Assembly and budding of VSV: Matrix protein polymerization properties and ability to deform membranes.

• Rhabdovirus-host interactions: Structure and function of rabies virus Negri bodies, interaction of rabies virus glycoprotein with the folding machinery of the ER, of VSV matrix protein with dynamin, etc.