Scientific topics
Keywords
ITMO
Emmanuel Valjent PhD Neuroscience
Course and current status
Short CV of the Team leader
Education / Training
1992 Baccalaureate (Biology)
1997 Master in Cell Biology and Physiology (University Paris VI)
1998 DEA in Neurosciences (University Paris VI)
2001 PhD in Neurosciences (University Paris VI and University Pompeu Fabra, Barcelona)
2014 “Habilitation à diriger des recherches” (HDR), Montpellier I University
Positions Held
2018-present: Group Leader, research Director 2nd class
2015-present Group Leader, Research Associate 1st class,
Inserm U1191, CNRS UMR5203, Univ Montpellier, Institute of Functional Genomic (IGF), Montpellier, France.
2009-2014 Group Leader “ATIP-Avenir Team”, Research Associate 1st class,
Inserm U661, CNRS UMR5203, Univ Montpellier I & II, Institute of Functional Genomic (IGF), Montpellier, France.
2007-2010 Visiting Scientist, Karolinska Institutet, Department of Neuroscience, Stockholm, Sweden.
2005-2009 Research Associate 2nd class, Inserm U536 and U839, Institute du Fer à Moulin, Paris, France. (with Jean-Antoine Girault, M.D., Ph.D.)
2001-2004 Post-Doctoral Fellow, Inserm U536 (with Jean-Antoine Girault, M.D., Ph.D.)
1998-2001 Graduate Student, Department of Neuropsychopharmacology, Univ Pompeu Fabra, Barcelona, Spain (with Pr. Rafael. Maldonado, M.D, Ph.D.) and CNRS, Univ Paris VI, Paris, France (with Jocelyne Caboche, Ph.D.).
1997-1998 Pregraduate Student, Inserm U266 (Pr. B.P. Roques)
Honors and Fellowships
ATIP-Avenir Award 2009-2014
Swedish Research Council Fellowship 2008-2010
Fondation pour la Recherche Medicale (FRM) Student Fellowship 2001
Fondation des Treilles Student Fellowship 1999-2000
Professional Affiliations
American Society for Neuroscience
French Society for Neuroscience
Publications (94 publications in Pubmed, h=42)Scientific summary
Selection and execution of appropriate behavioral responses rely on the ability to properly use sensory information to predict future rewards or punishments. The dorsal striatum and the nucleus accumbens are two major structures critically involved in this learning process. We put forward that the regulation of local mRNA translation control, resulting from the integration of glutamate-mediated sensory information and dopamine-mediated reward signals, could be an important process that elicits the neuronal plasticity required for striatal-dependent learning. The general objective of our research aims to characterize the molecular mechanisms involved mRNA translational control resulting from the integration of dopamine and glutamate signals and to understand the functional impact of such events on dopamine-controlled learning and pathology. Beyond its implication in basic science, our project may also provides important information for the development of new therapeutic strategies in neurological and psychiatric disorders related to striatal dysfunction such as Parkinson’s disease, obsessive-compulsive disorder and drug addiction.
