CV Science

Laurent Mathieu PhD student

Course and current status

- Perfusionist – Adult and Pediatric Cardiac Surgery Operating Room (Bordeaux University Hospital)

- Research Module Coordinator, Master’s Program in CPB and Mechanical Circulatory Support (Sorbonne University)

Academic Background
· 2023 – Master’s Degree in Science and Technology, Health Track, CPB Program (Sorbonne University)
· 2020 – University Diploma in Research (University of Bordeaux)
· 2012 – University Diploma in Cardiopulmonary Bypass and Organ Support (University of Bordeaux)

Scientific summary

Nearly 50% of patients develop acute kidney injury after cardiac surgery with cardiopulmonary bypass. This complication is multifactorial, but CPB and the alteration of tissue oxygenation play a major role. Understanding the mechanisms that disrupt tissue oxygenation and trigger an inflammatory response is essential for developing more protective perfusion strategies.

Our project aims to analyze tissue oxygenation during CPB while considering three major potential modulators: the preoperative inflammatory state, perfusion techniques such as hypothermia or hemofiltration, and pharmacological strategies such as the administration of nitric oxide through the CPB gas flow. The evaluation of these mechanisms relies on monitoring key parameters of oxygen transport and utilization, as well as measuring serum biomarkers that reflect the different stages of the inflammatory and microcirculatory response. These markers include pro- and anti-inflammatory cytokines, mediators of leukocyte, platelet, and endothelial activation, and indicators of glycocalyx degradation.

The overall objective is to better characterize the determinants of tissue oxygenation during CPB and to pave the way for truly personalized perfusion, focused on preventing organ dysfunction, particularly postoperative acute kidney injury.