Didier Pinault
  • E-mail :[email]
  • Phone : 0368853245
  • Location : Strasbourg, France
Last update 2022-02-14 11:31:46.661

Didier Pinault PhD Neurosciences

Course and current status

Academic essentials

  • 1974: Bachelor in Biological Sciences, Lycée Technique d’Etat, Bourges, France.
  • 1990: PhD in Neuroscience, Université Pierre et Marie Curie, Paris 6, France.
  • 2001: Accreditation to supervise research, Université Louis Pasteur, Université de Strasbourg, France.
  • 1997-: Invited reviewer for peer-reviewed Journals.
  • 2002-: Invited reviewer for national and international funding organizations.
  • 2009-: Guest Editor of European Journal of Neuroscience.
  • 2011-: Review Editor of Frontiers in Schizophrenia.
  • 2010-: Member of the GDR multi-électrodes; Member du club de Modulation Cérébrale de l’AFPB.
  • 2010-: Faculty Member of the Trinational Joint Master in Neuroscience (Basel, Freiburg, Strasbourg).
  • Other: Member of the American, European and French Societies of Neuroscience.


  • 1975-83: Engineer, electro-neuropharmacology, Delalande Laboratories, Rueil-Malmaison, France.
  • 1984-90: Thesis in Neurosciences, INSERM U97, Université P & M Curie, Paris 6, France.
  • 1990-92: Postdoc Res, Laval University, Québec, neurophysiology of thalamocortical systems.
  • 1992-97: Res Ass, Laval University, Québec, neurophysiology of thalamocortical systems.
  • 1997-2002: Engineer, Inserm U398, Univ L Pasteur, Université de Strasbourg, pathophysiology of cortex-thalamus systems.
  • 2002-2007: Engineer, Inserm U405 then U666, Université de Strasbourg, dynamics and pathophysiology of cortex-thalamus systems.
  • 2007-: CR, A/Prof, Inserm U1114, Université de Strasbourg, Pathophysiology and Neuromodulation of Cortex-Thalamus Systems.


Major discoveries

  • 1985-1990: New functional integration concept: Axon terminals integrate local environmental signals and generate backpropagating action potentials. Thesis work: Brain Res Rev, 1995.
  • 1991-1996: Make visible the invisible: The juxtacellular technique to reveal the morphofunctional properties of single neurons. J Neurosci Methods, 1996.
  • 1995-1998: The first anatomical demonstration of the principle of lateral inhibition in the thalamus. Eur J Neurosci, 1998.
  • 1997-2005: A new cell-to-network pathophysiological concept in epilepsy: Layer VI corticothalamic neurons initiate spike-and-wave discharges in genetically determined absence seizures. J Physiol, 2003.
  • 1997-2005: State-of-the-art micro-neurosurgery for cell-to-network electrophysiological approaches: A micro-cranioduratomy, state-of-the-art technique to explore the structure and function of living intact neurons and networks. J Neurosci Methods, 2005.
  • 2002-: Toward a new pathophysiological concept in schizophrenia: Electrophysiological signature in a new model for pathogenesis of psychoses. Biol Psychiatry, 2008.
  • 2009-: Toward a preclinical neurophysiological therapeutic concept: A neurophysiological perspective on a preventive treatment against schizophrenia using transcranial electric stimulation of the corticothalamic pathway. Brain Sci, 2017.

Recent/current fellows:

  • 2003: Cristina Soto Sánchez, University of Santiago de Compostela, Spain. Spanish Ministry for Science and Technology.
  • 2004-06: Andrea Slézia, Inst Exp Med, Budapest, Hungary. Marie-Curie Research Training Progam.
  • 2006-07: Terence J O’Brien, Prof, University of Melbourne, Australia. Sabbatical.
  • 2007: Emilie Doucet, M2 in BCGMP, University of Rennes 1.
  • 2007-10: Thomas Zheng, PhD student, Univ of Strasbourg & Melbourne. Bourse d’excellence Eiffel Doctorat.
  • 2008: Julien Gaudias, M2 student Neurosciences, Univ of Strasbourg.
  • 2008: Elena A Tolmacheva, Inserm postdoctoral researcher.
  • 2009: Joseph Chaumont, M2 student Neurosciences, Univ of Strasbourg.
  • 2009-: Sofya Kulikova, Trinational Joint Master in Neuroscience (univ of Strasbourg, Freiburg and Basel).
  • 2009-2010: Mehdi Ordikhani, Trinational Joint Master in Neuroscience (univ of Strasbourg, Freiburg and Basel).
  • 2010-11: Brendan E Adams, Neurex-UdS postdoctoral researcher.
  • 2010-11: Anne-Sophie Bouillot, Licence PRO physiopathologie/pharmacologie (Univ Joseph Fourier, Grenoble).
  • 2011: Florian Stern, M1 student Mathématiques, Univ de Strasbourg.
  • 2010-14: Paul Anderson, PhD student of Univ of Strasbourg & Univ of Melbourne.
  • 2015-: Yi Qin, PhD student, Neurotime Erasmus Mundus + program of the EC, Univ of Strasbourg and Amsterdam.
  • 2016-: Ali Mahdavi, PhD student, Neurotime Erasmus Mundus + program of the EC, Univ of Strasbourg, France, and Univ of Freiburg, Germany.
  • 2016: Marine Bertschy, M2 student Neurosciences, Univ of Strasbourg.
  • 2019: Anne-Sophie Aubry, graduate student from the Euridol Graduate School of Pain, Univ of Strasbourg.
  • 2020: Caroline Lahogue, M2 student Neurosciences, Univ of Strasbourg.
  • 2020-: Joséphine Riedinger, PhD student Neurosciences, Univ of Strasbourg (co-director: Axel Hutt, INRIA).
  • 2021: Ugo Tissot, M2 student Neurosciences, Univ of Strasbourg.
  • 2021: Jessica Link, M2 student Neurosciences, Univ of Freiburg.


  • LMD Université de Strasbourg and European Neurex Network;
  • Research training from & for Biomedical Research;
  • Electrophysiology School of Strasbourg.

Selection of Invited Conferences, Workshops, Symposia, etc.:

  • 2003, Basel: Trinational Neurex Workshop on Cerebral Rhythms.
  • 2003, Strasbourg: Colloque Imagerie et Photonique pour les Sciences du Vivant et la Médecine (IMVIE).
  • 2005, Göttingen: German Symposium on neuronal activity, synaptic transmission and network dynamics.
  • 2006, Vienne: European FENS Technical Workshop on Noninvasive High Resolution Recording Techniques.
  • 2007, Antalya: CEA-ILAE Symposium on Idiopathic Generalized Epilepsies.
  • 2008, Nurnberg: 2nd World Conference on Magic Bullets on Psychoactive drugs.
  • 2008, Rouffach: IPEG Symposium on EEG and NMDAr antagonists.
  • 2008, Seattle: AES Workshop on Cortical focus of Absence Seizures.
  • 2009, Strasbourg: 8eme Journée Pierre Deniker.
  • 2009, Paris: 9th World Congress of Biological Psychiatry on Psychotic disorders.
  • 2010, Strasbourg: International Neurex Workshop on Deep Brain Stimulation.
  • 2010, Aix: Journée Neurosciences: avancées, partenariats et médicaments de demain.
  • 2010, Boppard: Swiss-German Symposium on Barrel Cortex Function (BaCoFun).
  • 2011, Freiburg: International Neurex Berstein Conference on Basal Ganglia and Deep Brain Stimulation.
  • 2011, Berlin: DGPPN, Berlin Psychiatry Congress, Neural Oscillations in Schizophrenia.
  • 2012, Heidelberg: Berstein R&D Workshop Cellular Electrophysiology.
  • 2016, Budapest: 1st International Conference on Sleep Spindling.
  • 2017, Copenhagen: 13th World Congress of Biological Psychiatry.
  • 2018, Paris: Conference Neurology & Neurological disorders
  • 2019, Lille: Le congrès du sommeil

Scientific summary

A modern approach of the mind-brain problem:

My goal is to develop, using preclinical models, innovative therapy to treat and prevent neuropsychiatric disorders. It is a conceptually- and data-driven long-term investigation based on the pathophysiological properties of neural networks. EEG combined with multisite cell-to-network exploration are implemented to measure the functional state of Cortico-Thalamo-Cortical systems under physiological, pathological, and therapeutic conditions. CTC systems are the fundamental, oscillating neural substrates of consciousness and attention-related sensorimotor and cognitive processes, and they are suitably electro-responsive to non-invasive, transcranial electrical stimulation.

Image d’exemple