• E-mail :[email]
  • Phone : +33 4 72 72 84 11
  • Location : Lyon, France
Last update 2016-06-14 17:31:34.395

Dutartre Helene PhD

Course and current status

Administrative Leadership Appointments

2001 – June 2008      Coordinator & development of the HCV project “enzymatic characterization and discovery of new drugs targeting HCV-polymerase”.

AFMB-CNRS Laboratory, Department of Structural Virology and Drug Design; B. Canard team.  Marseille, France.

Feb 2009-dec 2011     Coordinator & development of the HCV project “toward an HCV vaccine.”

Chargé de Recherche INSERM (CR1) / Senior Scientist position.

Baylor Institute for Immunology Research. Dallas TX. Center for human Vaccines -

INSERM U899. Director Jacques Banchereau.

Jan 2012-present      Coordinator & development of the HTLV project “interplay between host innate cells and HTLV virus”. Retroviral Oncogenesis team head by Pr Mahieux. Chargé de Recherche INSERM (CR1) / Senior Scientist position.

Center for International Research on infectiology, Lyon, France. Renaux Mahieux team.  Director François-Loïc Cosset.


Academic Appointments

1999 – 2001                Associate Professor (lecturer) (ATER).  Université de la Méditerranée (Aix-Marseille II). The research work was done in H. van Thilbeurgh's team, at AFMB.  Marseille, France.

                                    Research program: In vitro and crystal studies of Bacillus Subtilis LicT antiterminator.

1997 – 1999                Coordinator of Science Education.  International Bilingual High School.  Boston, MA.

Feb 2005                     Recruited in a permanent position at INSERM as Chargé de Recherche (CR2) / Senior Scientist position.

June 2008- present             Promoted by INSERM as first class Chargé de Recherche (CR1) / Senior Scientist position.



1992 – 1993                Post-graduate specialization diploma in Immunology (MS) (awarded with honors).  CIML Centre d'Immunologie de Marseille Luminy.  Directed by P. Chavrier.  Marseille, France.

                                    Research program: CDC42Hs function in actin-cytoskeleton organization and cellular polarization.

Sept 1993 – Oct 1997           Ph.D. in Immunology (awarded with honors).  Laboratoire de Cancérologie expérimentale, U119 INSERM.  Directed by D. Olive.  Marseille, France.

                                    Research program: Molecular characterization of the NEF-HIV interaction with SRC-related tyrosine kinase.

Sept 2001 – Dec 2004           Postdoctoral fellow and Associate Researcher.  Laboratoire d’Architecture et Fonction des Macromolécules Biologiques (AFMB); B. Canard's team.  Marseille, France.

                                    Research program: Expression, purification and characterization of HCV, BVDV and GBVC RNA-dependant RNA-polymerase. Drug discovery and antiviral mechanism of compounds.

June 2008                  University thesis in life sciences (Habilitation a diriger la recherche-HDR). UNIVERSITE DE LA MEDITERRANEE AIX-MARSEILLE II, under the tutoring of Dr. B.Canard.  Marseille, France.

                                    Research program: Biochemical and Structural characterization of the HCV polymerase.


Other Professional Appointments

  • 2010 / present :   Reviewer for the Journal and General Virology and Microbial Pathogens; Leukemia and Lymphoma; Future Virology; Frontiers in Virology; Blood; Journal of Immunology.
  • 2006-2007 :         Reviewer for the European Journal of Medicinal Chemistry
  • Member / present          French Society:  Societe Francaise de Virologie, Club Français des cellules dendritiques. American Society for Microbiology.
  • International society : HTLV
    • Jan 2012-june 2016        Elected member of the national scientific committee of INSERM (CSS7).

Scientific summary

Helene Dutartre is a senior scientist from INSERM. She obtained a PhD in 1997 in Immunology from the Université de la Méditérannée (Marseille, France) at the research center for cancerology of Marseille (CRCL, Marseille.). She has a back ground on HIV and HCV virus-host interaction, at the interface of immunology and virology acquiered from her training in the teams of Pr Daniel Olive (CRCL, Marseille France), Dr Bruno Canard (AFMB, Marseille, France) and Dr Jacques Banchereau (BIIR, Dallas Tx, USA). In Pr. Renaud Mahieux’ team since 2012, her current interest focuses on understanding the interaction between the HTLV-1 oncovirus with innate cells, to provide new strategies for anti-cancer treatment.

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