Scientific topics
Keywords
Abderrahim LOMRI Reactive oxygen species and superoxide dismutases: role in joint diseases & cancer
Course and current status
Current Title : Senior Investigator (First Class)
Marital Status: Married with two children
Nationality French
Education
Degrees University & Location Scientific Field Year
B.S. University of Clermont Cellular Biology 1983
Ferrand II, France & Biochemistry
M.S. " Cellular Biology 1984
& Genetic
D.E.A. University P & M Curie Human Health 1985
Paris VI, France
Ph.D. " Cellular Biology 1988
Post-doc Dept Cell Biol, Yale Cellular & Molecular 1989-1992
University (USA) Biology
Visiting Professeur, UCSF (USA). Cellular Biology 1999-2000
Fields of Expertise
Cell culture:
- Development of primary cell cultures
- Cellular immortalization
- Development of new cell lines
- Evaluation of new drugs on cell growth & cell function
Screening for active pharmaceutical compounds
- In vivo & In vitro using cell culture models
- At the protein & gene levels
Scientific summary
My research program concern the role of oxidative stress in bone & cartilage function and cancer, the expression of specific genes under pro-inflammatory conditions and the identification of signaling pathways involved. Furthermore, the use of molecular & cellular biology tools and the different human cell lines developed in my lab will help us to identify new genes involved in such pathology in order to develop new active pharmaceutical compounds to inhibit or stimulate a specific pathway.
We have also developed molecular tools (human TNF-alpha & SOD-1 promoters) that are useful to screen for active estrogenic or anti inflammatory compounds.
