Patrice Quintana - CV - PhD Neuroscience

E-mail :[email]
Phone : +33 777 99 12 18
Location : Clermont-Ferrand, France

Scientific topics

Neuroscience & Behavior
Biology & Biochemistry

Keywords

ITMO

Last update 2025-06-20 19:20:27.977

Patrice Quintana PhD Neuroscience

Course and current status

Development of human iPSCs, genesis and characterization of hIPSC derived peripheral sensory neurons, glial cells and DRG organoids. Screening of molecules with therapeutic potential in the context of CIPN. Training of 1 PhD student and 1 technician. Teaching students.

NEURO-DOL, INSERM-UCA U1107 - Team “Pain and Cancer, Faculty of Medicine, Clermont-Ferrand, France

Nov 2018 - June 2020 and march 2021 - sept 2023 :

-Study of myelin and actin organization in PNS neurons from CMT4H patients / animal models with CARS imaging and Immunohistochemistry approaches.

-Exploration of deleterious molecular mechanisms and pathogenic interactions of mutated GARS1 with known and new partners in spinal motoneurons differentiated from IPSCs of CMT2D patient.

-Study of functionnal alterations and AIS shortening in hiPSC-derived motor neurons of patients affected with distal Hereditary Motor Neuropathy presenting mutations in VRK1. Training 1 postdoc and 2 PhD students to MEA electrophysiology system.

Translational Neuromyology - Marseille Medical Genetics INSERM U1251, Faculty of medicine, Marseille, France

November 2017 - april 2018 : in order to perform functional analysis of calcium channels in human iPSCs derived RPE cells from patients and healthy persons using electrophysiological approach, specific pharmacology and calcium imaging (Fura2) I developed patch clamp and calcium imaging setups and participated to Master student training for calcium imaging technique.

Team “Genetics-therapy of retinal blindness and optic neuropathies", Institute for Neurosciences of Montpellier, Montpellier, France.

May - december 2015 and july 2016 - february 2017 : I studied the effects of temporary sensory deprivation on auditory skills : short, middle and long term modifications in the inner ear and mechanisms. To this end I developped several animal models of temporary hearing deprivation. I was also involved in preclincal investigations on postoperative incidence of antifibrotics.

Team "Deafness, tinitus and therapies", Institute for Neurosciences of Montpellier, Montpellier, France. Postdoctoral researcher.

April 2015 : I designed, demonstrated feasibility and set up a nomad electrophysiological saphenous nerve stimulation system on anesthetized rodent in a two-photon microscopy station. The finality will be to visualize in vivo mitochondrial behavior in ensheathing glial cells of nerve fibers stimulated electrophysiologically. I initiated a PostDoc to the specific surgery and electrophysiological approach.

Team “Molecular mechanisms of myelination/demyelination and gene therapy approaches in peripheral nerves”, Institute for Neurosciences of Montpellier, Montpellier, France. Researcher electrophysiologist.

Jan 2013-Dec 2014 : I evaluated the physiological and pathophysiological states of somatosensory system in the context of the study of a new mechanism that controls chronic neuropathic pain. I also investigated the effects of LEDs on these states. To these ends I implemented, developped and used the electrophysiology skin-nerve technique.

Team “Neural differentiation and connectivity in the somatosensory system”, Institute for Neurosciences of Montpellier, Montpellier, France. Post-Doc.

Oct 2011-Dec 2012 : I investigated postischemic excitotoxicity and acidotoxicity harmful effects on Central Nervous System tissue. I determinated the degree of cooperativity between these two nocive pathways in order to increase the therapeutic efficiency and time window of specific blockers.
I also preformed compounds screening and testing (field: Alzheimer disease therapeutics) in collaboration with AC Immune, a biopharmaceutical company.

Department of medical genetics, University of Lausanne, Lausanne, Switzerland. Research Associate - Post Doc.

Oct 2000-Jun 2006 - I studied short and long term modifications of glutamatergic neurotransmission induced by anoxia / hypoglycemia in CNS.

Department of Neuroscience - University Medical Centre, Geneva, Switzerland. Research assistant – Certificate of Specialization in Medical Biology and Thesis work.

Scientific summary