CV Science

Patrice Quintana PhD Neuroscience

Course and current status

Since november 2018 : involved in development of novel optical instrumentation and molecular tools that will allow molecular-scale, real-time measurements of myelin and actin organization in cells and tissues. Translational Neuromyology - Marseille Medical Genetics, Faculty of medicine, Marseille, France

November 2017 - april 2018 : in order to perform functional analysis of calcium channels in human iPSCs derived RPE cells from patients and healthy persons using electrophysiological approach, specific pharmacology and calcium imaging (Fura2) I developed patch clamp and calcium imaging setups and participated to Master student training for calcium imaging technique.

Team “Genetics-therapy of retinal blindness and optic neuropathies", Institute for Neurosciences of Montpellier, Montpellier, France.

May - december 2015 and july 2016 - february 2017 : I studied the effects of temporary sensory deprivation on auditory skills : short, middle and long term modifications in the inner ear and mechanisms. To this end I developped several animal models of temporary hearing deprivation. I was also involved in preclincal investigations on postoperative incidence of antifibrotics.

Team "Deafness, tinitus and therapies", Institute for Neurosciences of Montpellier, Montpellier, France. Postdoctoral researcher.

April 2015 : I designed, demonstrated feasibility and set up a nomad electrophysiological saphenous nerve stimulation system on anesthetized rodent in a two-photon microscopy station. The finality will be to visualize in vivo mitochondrial behavior in ensheathing glial cells of nerve fibers stimulated electrophysiologically. I initiated a PostDoc to the specific surgery and electrophysiological approach.

Team “Molecular mechanisms of myelination/demyelination and gene therapy approaches in peripheral nerves”, Institute for Neurosciences of Montpellier, Montpellier, France. Researcher electrophysiologist.

Jan 2013-Dec 2014 : I evaluated the physiological and pathophysiological states of somatosensory system in the context of the study of a new mechanism that controls chronic neuropathic pain. I also investigated the effects of LEDs on these states. To these ends I implemented, developped and used the electrophysiology skin-nerve technique.

Team “Neural differentiation and connectivity in the somatosensory system”, Institute for Neurosciences of Montpellier, Montpellier, France. Post-Doc.

Oct 2011-Dec 2012 : I investigated postischemic excitotoxicity and acidotoxicity harmful effects on Central Nervous System tissue. I determinated the degree of cooperativity between these two nocive pathways in order to increase the therapeutic efficiency and time window of specific blockers.
I also preformed compounds screening and testing (field: Alzheimer disease therapeutics) in collaboration with AC Immune, a biopharmaceutical company.

Department of medical genetics, University of Lausanne, Lausanne, Switzerland. Research Associate - Post Doc.

Oct 2000-Jun 2006 - I studied short and long term modifications of glutamatergic neurotransmission induced by anoxia / hypoglycemia in CNS.

Department of Neuroscience - University Medical Centre, Geneva, Switzerland. Research assistant – Certificate of Specialization in Medical Biology and Thesis work.

Scientific summary

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