Scientific topics
Keywords
Marc Ferré MEng French Grande Ecole, PhD Bioinformatics
Course and current status
Marc Ferré graduated in 2002 from a French "Grande École d'Ingénieur" (graduate school of engineering, ESEO), in 2009 a PhD in Bioinformatics and in 2022 the Habilitation (“accreditation to supervise research”, Habilitation à diriger des recherches in French). Until August 2014, he was employed by the University Hospital of Angers (France) as bioinformatician through the formation of a national network coordinated by the French Department of Health (genetic study of neuromuscular and sensory pathologies, and mental retardation).
He is currently Associate Professor in Molecular Biology and Bioinformatics at the Angers Medical School.
He is also a staff member of the research team UMR CNRS 6015/INSERM 1083 — CNRS, The Centre National de la Recherche Scientifique (National Center for Scientific Research), is a government-funded research organization, under the administrative authority of France’s Ministry of Research; INSERM, the Institut national de la santé et de la recherche médicale (French National Institute of Health and Medical Research), is a public scientific and technological institute which operates under the joint authority of the French Ministry of Health and French Ministry of Research.
Dr. Ferré’s h-index is 25 or 29 according to Web of Science or Google Scholar (i.e., 25/29 articles are cited more than 25/29 times). He has published 47 articles in international, peer-reviewed journals since 2004. Of these, 45 are original articles and 2 are reviews, 5 as first author (2005–2015) and as last author (2011–2021). They were cited 1,764 times (1,676 without self-citations), for an average of 37.5 citations per article (data from the Web of Science Core Collection); 2,810 times, according to Google Scolar)
Scientific summary
Research activity of Dr. Ferré has been conducted in the field of mitochondrial diseases.
He began his career by studying in silico the human mitochondrial proteome and developing a bioinformatics research strategy to identify new mitochondrial proteins on the basis of their prokaryotic origin. In parallel to this overall strategy of screening, he focused on the study of the Opa1 protein, one of the proteins associated with dominant optic atrophy, which is involved in mitochondrial fusion. Opa1, a dynamin GTPase, is involved in the remodeling of the inner mitochondrial membrane, apoptosis, maintenance of mitochondrial DNA, and energy metabolism. He finally developed an international database listing the variations of Opa1 so as to characterize its mutational spectrum. This tool was used as a complement to a multicentric clinical study involving thousands of patients with optic neuropathy. His work has led to the development of novel bioinformatics tools that should contribute to a better understanding of mitochondrial pathophysiology.
He is currently focused on three axes: (1) designing and the curating clinico-biological databases of genes involved in neuro-ophthalmological diseases (ACO2, DNM1L, MFN2, NR2F1, OPA1, RTN4IP1, SPG7, SSBP1), as a member of the Global Variome (ex-Human Variome Project) since 2012 and Clinical Genome Resource (ClinGen) since 2020; (2) exceeding the current reading limits of the human mitochondrial genome sequence and its modifications, via an innovative technique in which the complete double-stranded mitochondrial DNA is read directly without DNA amplification or incorporation of nucleotides; (3) analyzing the big data generated by the two previous axes, by biostatistical methods, bioinformatics and artificial intelligence, towards a Molecular Medicine approach.
He has supervised 7 theses in science and especially in medicine specializing in ophthalmology, with each supervision resulting in an article of which the student is first author (except one as second author); he is currently co-supervising 5 theses in general practice.
