CV Science

Andre BADO PhD Gastrointestinal Physiology

Course and current status

Education

1983 Master in Animal Physiology (University Paul Sabatier Toulouse)

1984, Advanced Master in physiology and pathophysiology of nutrition

1986 Doctorate in the special field of digestive physiology University of Paris 7

1988 PhD thesis in animal physiology (University of Paris 7- Denis Diderot)

Positions

1992-1998 Senior Researcher, Principal Investigator (PI) at INSERM unit 10 (Head: MJM Lewin) ;

From 1998 at present: Research Director & PI  at INSERM U10, U683 and U773

Presently Head of Team 2: Gastrointestinal Physiology and Endocrinology [INSERM U773 (Dir: M. Laburthe)]

Field of Expertise:  Physiology – acid secretion, gut endocrine cells, nutrients, intestinal transporters, leptin, nutrition, regulatory peptides.

Scientific activities  Member  of Scientific Committee of Faculty of Medicine Paris 7– Denis Diderot (2002-2009);  - Member  of  the Scientific  Committee of  the Francophone Digestive Disease Week [JFHOD] ( 2001 - at present) ,  Member  of  the Scientific  Committee of  the Francophone Society of nutrition ( 2010 - at present) ,

Teaching / Training Activities:  Co-Head of Gastroenterology and Hepatology Course  in  Master 2 ESI  at University Paris 7; . Teacher  in 4 other Masters  in Physiology and Biology of integrated biological systems at University Paris 7, University Paris 5  & 13, University of Montpellier 2; (developed themes of courses: Disorders of Feeding behaviour, Gastrointestinal hormones and feeding, Physiologic of gastric Acid Secretion, Intestinal transporters of Nutrients)

Supervisor of 3 postdoc, 6 PhD thesis (defence completed), 13 master’s students.  External Examiner of 14 PhD Theses.

Editorial activities : Regular peer Review  for 19 international scientific journals (Journal of Clinical Investigation, gastroenterology, Journal of Neuroscience, Brain Research, TIPS, Diabetes, American Journal of Physiology, Faseb J, , Endocrinology….)  Evaluation Expert for scientific foundations, Institute and Associations in France, Europe  and  USA

Invited Speaker in at least 12 national and international scientific meeting, Chairman/co-chairman  in 6 scientific symposia & meetings.

Scientific Output and 10 selected articles

Description of H3-receptor in gastric mucosa, Discovery of leptin in the stomach. 69 original papers,  4 chapters, 102 selected oral or poster presentations at  scientic meetings.

1. Brasse-Lagnel C., Karim Z, Letteron P, Bekri S, Bado A, Beaumont C. Intestinal DMT1 cotransporter is downregulated by hepcidin via proteasome-internalization and degradation" Gastroenterology 2011, 140 (4):1261-1271
2. Sakar Y, Nazaret C, Lettéron P, Ait Omar A, Avenati  M, Viollet B, Ducroc  Bado A.  Positive regulatory control loop between gut leptin and intestinal GLUT2/GLUT5 transporters links to hepatic metabolic functions in rodents. PLoS ONE 2009, 4(11): e7935. doi:10.1371
3. Ducroc R, Guilmeau S, Akasbi K, Devaud H, Buyse M, A Bado.  Luminal leptin induces rapid inhibition of active intestinal absorption of glucose mediated by sodium-glucose co-transporter, SGLT-1.  Diabetes 2005;54(2):348-54.
4. Rouet-Benzineb P, Aparicio T, Guilmeau S, Pouzet C, Descatoire V, Buyse M, Bado A. Leptin counteracts sodium butyrate-induced apoptosis in human colon cancer HT-29 cells via NF-kappaB signaling. J Biol Chem 2004;279:16495-50
5. Guilmeau S, Buyse M, Tsocas A, Laigneau JP, Bado A. Duodenal leptin stimulates cholecystokinin secretion: evidence of a positive leptin-cholecystokinin feedback loop. Diabetes 2003;52:1664-1672. 
6. Buyse M, Sitaraman SV, Liu X, Bado A, Merlin D. Luminal leptin enhances CD147/MCT-1-mediated uptake of butyrate in the human intestinal cell line Caco2-BBE. J Biol Chem 2002;277:28182-90. 
7. Sobhani I, Buyse M, Goiot H, Weber N, Laigneau JP, Henin D, Soul JC, Bado A. Vagal stimulation rapidly increases leptin secretion in human stomach. Gastroenterology 2002;122:259-63. 
8. Buyse M, Berlioz F, Guilmeau S, Tsocas A, Voisin T, Peranzi G, Merlin D, Laburthe M, Lewin MJ, Roze C, Bado A. PepT1-mediated epithelial transport of dipeptides and cephalexin is enhanced by luminal leptin in the small intestine. J Clin Invest 2001;108:1483-94. 
9. Buyse M, Viengchareun S, Bado A, Lombes M. Insulin and glucocorticoids differentially regulate leptin transcription and secretion in brown adipocytes. Faseb J 2001;15:1357-66.
10. Bado A, Levasseur S, Attoub S, Kermorgant S, Laigneau JP, Bortoluzzi MN, Moizo L, Lehy T,  Guerre-Millo M, Le Marchand-Brustel Y, Lewin MJ. The stomach is a source of leptin. Nature 1998; 394:790-793.

Scientific summary

 Over the last years, my group is being  studying the neuropeptidergic control of secretions and absorption of nutriments and their contribution to mechanisms regulating energy homeostasis. One interest is in developing a better understanding of the physiological contribution of  meal-generated gastrointestinal signals including gut leptin to the development of obesity and its relation to colon carcinogenesis. Transgenic mice deleted with epithelial cell leptin receptors in the intestine were used. A second interest to better understand the mechanisms  by which gastro-intestinal epithelial cells adapt during over-nutrition and malnutrition conditions. This consists in dissecting the mechanisms involved in modifications of expression/ activity of gut endocrine cells, of key transcription factors reprogramming absorptive capacity of the enterocytes and controlling the renewal (proliferation/differentiation) of gut epithelial cells. A better understanding of the mechanisms driving these adaptations are essential for the development of novel and innovative therapies for the treatment of pathologies such obesity.