CV Science

Richard Redon PhD, Research Director, Inserm, Genetics and Bioinformatics

Course and current status

Titles and Certifications

• 2008 : HDR, University of Nantes (FR)
• 2002 : PhD in Life Sciences, University of Strasbourg (FR)
  PhD thesis: Contribution to the genetic progression model of head and neck cancer: the DNA microarray technology to screen tumour genomes
  Co-supervisors: S du Manoir / JL Mandel, IGBMC (Inserm/CNRS/University of Strasbourg)
• 1998 : Master's degree in Molecular and Cellular Biology, University of Strasbourg (FR)

Career Development

• 2013 – present: Research Director (DR2) at Inserm
• 2010 – present: Leader of Team 4: 'Genetic Variation and Sudden Death' at the institut du thorax laboratory (Inserm UMR 1087 / CNRS UMR 6291), Nantes (FR)
• 2010 - present : Director of the Genomics and Bioinformatics Core Facilities of Nantes (FR)
• 2009 - 2013 : Senior Research Associate (CR1), Inserm, L'institut du thorax, Nantes (FR)
• 2003 - 2009 :  Research Associate, Genome Research Limited, Molecular Cytogenetics Group, The Wellcome Trust Sanger institute, Cambridge (UK)
  Director: Dr Nigel Carter

Scientific summary

Biosketch

Since the publication of the first map of copy number variation in the human genome (Nature, 2006), Richard Redon has been recognized as an international expert in the analysis of structural variation in the human genome.

After his appointment as researcher by the Inserm in 2009, he has contributed to the development of NGS-based approaches to adress the genetics of rare diseases (Bioinformatics 2011). He has more recently been leading a large collaborative study aiming to identify genetic variation associated with sudden cardiac death by genome-wide association studies (Nature Genetics, 2013).
Richard Redon leads the team « Genetic variations and sudden death » at l'institut du thorax (Inserm unit 1087 / CNRS unit 6291 / University of Nantes).

He is also coordinator of the genomics and bioinformatics core facility of Nantes, which is part of a platform recognised as a French national infrastructure (IBiSA). The core facility runs NGS experiments on HiSeq/MiSeq machines (Illumina) as well as high-throughput DNA genotyping on Axiom SNP arrays (Affymetrix Gene Titan MC station). Data analysis relies on large computing resources (596 core processors; 3.4 To RAM, 300-TB of data-storage capacity).

Three key publications

• Bezzina CR, Barc J, Mizusawa Y, ... , Schott JJ, Dina C, Redon R. (2013) Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death. Nat Genet 45:1044-9
• Lindenbaum P, Le Scouarnec S, Portero V, Redon R. (2011) Knime4Bio: a set of custom nodes for the interpretation of next-generation sequencing data with KNIME. Bioinformatics 27:3200-1.
• Redon R, Ishikawa S, Fitch KR, ... , Jones KW, Scherer SW, Hurles ME. (2006) Global variation in copy number in the human genome. Nature 444:444-54