Scientific topics
Keywords
ITMO
Nathalie Dejucq-Rainsford Physiopathology of reproduction, sexually transmitted viruses, innate immunity
Course and current status
- Current Position
Director of Research (DR1) Inserm.
Head of the Inserm-labelled team “Physiology and physiopathology of the urogenital tract”, Irset-Inserm UMR 1085 (Rennes, France).
- Education and Degrees
2008............. HDR (Certification of ability ot direct research), Rennes 1 University
1997............. Doctorate in Cellular and Molecular Biology with honors, Rennes 1 University
1993............. Master of Advanced Studies (DEA) in Cellular and Molecular Biology with honors, Rennes 1 University
1992............. Master in Biochemistry with honors, Rennes 1 University
- Scientific Career
2012-present.. Team leader, Institute of Research on Health, Environment and Occupation (Irset – Inserm UMR 1085). Rennes, France
2023-present.. Director of Research (DR1) Inserm
2017-2020.. Vice-director of the research federative structure Biosit (UMS Inserm/CNRS/Rennes I University). https://biosit.univ-rennes1.fr/
2011-2022.. Director of Research (DR2) Inserm
2004-2011..... Senior scientist (CR1) Inserm, Inserm U 625, Rennes, France, co-team leader
2000-2004..... Research scientist (CR2) Inserm, Inserm U435, Rennes, France
1998-2000..... Research Scientist, University College London, London, UK
1997-1998..... Post-doctorate (Inserm awardee), Institute of Cancer Research, London, UK
1993-1997..... Doctorate, Inserm U435, Rennes, France
- Research Expertise
Physiology and physiopathology of the urogenital tract-Testis- Epididymis- Viral and chemical environment-Sexually transmitted infections- HIV-Arboviruses- Emerging viruses- Innate immunity – Organ culture
- Scientific Production and International Recognition
73 publications in peer-reviewed journals, h-index: 35. ORCID ID: 0000-0002-1788-2690
46 invited conference; 25 with international audience in US, Japan, China, Australia, Brazil, Germany, UK, Italy, The Netherlands, France.
17 invited reviews (Physiological Reviews, MMBR, Journal of Infectious Diseases, Nature Reviews Urology, Virology, International Journal of Andrology, Current Pharmaceutical Designs, Journal of Reproductive Immunology, Virologie, Medecine Sciences…)
20 communications in medias (Le Monde, Le Figaro, BBC news, France 5, France 3, Quotidien du médecin…), chapter on venereal diseases in the book “En pleine forme” for the promotion of health and environment (2019).
- Evaluation activities in academic committees
Since 2015..... Expert in the scientific committee “Host-virus interactions” of the ANRS-MIE (National research agency on HIV and emerging infectious diseases)
2023............. External expert for the Inserm scientific committee on physiopathology (CSS3)
2017-2022..... Member of Rennes I University Research Council
2013............. Expert in the Inserm selecting committee for clinicians “Contrats d’interface hospitalier”
2012-2017..... Member of the Commission Recherche Ecole Doctorale Vie-Agro-Santé, Rennes
2010-2012..... Member of the University Scientific advisory board UFR SVE, Rennes
2008-2012..... Expert member of the Inserm scientific committee on physiopathology (CSS4): team evaluation, researchers’ recruitment, activity and promotion
2011............. Expert for University selecting committees for lecturers (Paris 7 and Rennes 1).
- Other expertise activities and workgroups
2024-……………..Member of the board of directors of the French Andrology Society (SALF)
2023-……………..Expert for the French Ministry of Research and Innovation: appraisal of applications from private companies for tax credit
2022-……………..Expert within the ArboFrance network on Arboviruses
2022-……………..Member of the ANRS workgroup on Covid-19
2019- 2022.... Expert for the scientific board of Brittany regional research council for PhD stipends
2013- 2023.... Member of the Scientific Advisory board of the French Research group on Reproduction.
2013............. Member of the selecting committee for the Prix Bretagne Jeune Chercheur
2009............. Member of the Ministry of research workgroup “Secrétions et pharmacologie génitales” (Mission ministérielle Prévention et Réduction des risques dans les groupes à haut risques vis-à-vis du VIH et des IST)
2009............. Member of the workgroup “Etat des lieux et évolution de la recherche en Reproduction” (Institut thématique Génétique et Développement)
2009-............ Member of the Scientic Advisory board “Espace des Sciences”, Rennes: organization of scientifc seminar for the general public
2007-............ . Co-leader of the scientific animation committee “Agents pathogènes et maladies infectieuses” (SFR Biosit, Rennes)
Grant reviewing activities: ANR (expert and comittee member), ANRS, ANSES, Agence Nationale de Biomédecine, Fond de dotation P. Bergé-Sidaction, University of California San Diego, South African Medical Research Council, Italian Ministry of research, COFECUB Ecos-Sud, SFR ScInBioS, DIM cellules souches région Ile de France...
Reviewing for international journals and conferences: Nature Communications, Nature Urology, Human Reproduction Update, Frontiers in Immunology,AIDS, Faseb J, Retrovirology, Antiviral therapy, Human Reproduction, Journal of General Virology,PLoS One, Journal of Andrology, AIDS Human retroviruses, Reproduction, Systems biology in Reproductive Medicine, Open AIDS journal, Theriogenology, International AIDS conference...
Member >20 thesis and HDR juries, as well as Master 2 and doctoral school juries.
- Highlights and Awards
2024-2028........ Awardee of PEPR-Emerging Infectious Disease funding within the Cazikano consortium (463 k€ as PI)
2023................ Holder of ANSM authorization for work on pathogens at high risk for bioterrorism (MOT)
2023-2026........ Winner of Inserm individual activity prime
2022-2025........ PI of ANRS-MIE funding to study Mpox infection of the male genital tract (180 k€)
2022-2025........ Winner “Foundation for Research (FRM) certified team” on the role of innate immunity in viral persistence in the testis (341 k€)
2021................ Inserm rated “Remarkable” my 5 years activities and projects, as well as those of my Inserm-labelled team
2021-2025........ PI of ANR grant INNATESTIS (469 k€)
2021-2022........ PI of MSD International and Inserm REACTing funding to study SARS-CoV infection of the male genital tract (Covid-UrGenT, 330 k€)
2016-2020........ Awardee of European commission funding within the Zikalliance consortium: task leader on the sexual transmission of Zika Virus (179k€)
2009-2020........ PI of French AIDS research agency (ANRS) and Sidaction funding on HIV sexual transmission for a total > 1.5 Million €
2012-2015........ PI of Fond dotation P Bergé funding on HIV for 500 k€ (1 funded French partner and 3 non funded US teams)
1999................ Award of Brittany young researcher
1997-1998........ Inserm post-doctoral fellowship
- Teaching and Training
2000-present.... Supervision of 14 PhD students, 5 post-doctorates, 15 Master 2 students, 10 Master 1 and L3 students.
2004-present.... Teaching: Master 2 Biologie-Santé, Rennes 1 University; Master 1 Biologie Cellulaire & Physiologie, Rennes 1 University; Diploma of specialized study for medical students; European Doctoral College on Environment and Health (EDCEH), Rennes University.
Scientific summary
The objectives of my team are to address issues related to the uro-genital health, such as sexually transmissible infectious diseases and the impact of our biological and chemical environment on male and female reproduction and uro-genital cancers. To this end, we articulate classic biology, transcriptomics and single-cell genomics, with a combination of approaches encompassing unique ex vivo models of human organs, in vivo cohorts, volunteers and animal models, as well as in vitro and in silico analyses, in order to answer major public urogenital health concerns. The team encompasses about 40 members (researchers, clinicians, technicians, post-doc and PhD students) with complementary expertise in biology of reproduction, virology, toxicology, nephrology, gynecology, anatomo-pathology, cytogenetics, genomics and bio-informatics.
For more detail, www.irset.org
