CV Science

Chloe James MD, PhD

Course and current status

Professor Chloé James, is a MD, PhD, specialized in hematology and hemostasis. She holds the laboratory of hematology of the University Hospital of Bordeaux and a research group focused on the pathogenesis of thrombosis in Inserm 1034, Pessac-Bordeaux (https://u1034.bordeaux.inserm.fr). Her work especially focuses on myeloproliferative neoplasms-associated thrombosis with a particular interest in endothelial cells and neutrophils. Her research includes both clinical studies and fundamental approaches. Since the COVID-19 pandemic, she has also been working on the role and regulation of immunothrombrosis in severe COVID-19. 

She is now president of the French Society of Thrombosis and Hemostasis (SFTH) https://sfth.fr/, and belongs to the executive board of the French Intergoup on Myeloproliferative Neoplasms (FIM) https://www.fim-asso.fr/.

Scientific summary

She was laureate of the 2011 ATIP-Avenir-Fondation Bettencourt Schueller program. She actively participated in the discovery of the JAK2V617F mutation and since then, has been working in the field of myeloproliferative neoplasms and hematopoieisis. Since 2011, she focused on myeloproliferative neoplasms-associated thrombosis with a particular interest in endothelial cells and neutrophils. Her research includes both clinical studies (NCT04177576) and fundamental approaches.

She participates (as a PI or co-investigator) in different projects on:

- MPN-associated thrombosis: ANR ACTOR JAK2V617F clonality profile: identification of cell types involved in myeloproliferative disorders-associated thrombosis – ACTOR (ANR-22-CE17-0052) , https://anr.fr/Project-ANR-22-CE17-0052, ERA-CVD 2020 CHEMICAL (J Fuster)

- platelet disorders :ANR-DGOS-funded research project (ANR-18-CE17-0011, https://anr.fr/Project-ANR-18-CE17-0011) on unexplained thrombocytopenia (ICTUS), together with the group of William Vainchenker. ANR funded project: Bcl-xL deamidation in platelets: mere age marker, or lifespan modulator? – WRINXL (ANR-22-CE17-0050), https://anr.fr/Project-ANR-22-CE17-0050 with Muriel Priault

-NET degradation during COVID-19 (coordinator of the ANR-21-CO12-0006 project, https://anr.fr/Projet-ANR-21-CO12-0006).