CV Science

Patrice Péran PhD, Neuroimaging

Course and current status

Google scholar

orcid.org/0000-0001-7200-0139

ResearcherID: N-7561-2015

Scopus Author ID: 16320009700

 

 

 

~Current position~

Inserm research director

DEVIN team leader in Toulouse NeuroImaging Center  (ToNIC INSERM unit- UMR1214)

DEvelopment and Validation of biomarkers in MRI and Nuclear medicine (DEVIN) 

 DEVIN team web page

 

~Professional experience ~

2013 -2015 Co-founder and Chief Biomed Advisor of QuantaVita srl

2004-2010 Post-doc fellow in Radiology department of Santa Lucia Foundation (Rome, Italy). Manager of magnetic resonance translational studies.

~Education~

2015 HDR, Diploma to enable research supervision (University of Paul Sabatier, Toulouse)

2004 PhD in Neuropsychology and Neuroimaging entitled: "Verb Processing : Neuropsychology study in subcortical pathologies & Neuroimaging and Pharmacological study in healthy subjects"

Supervisors.: Pr D. Cardebat et Pr O. Rascol University of Le Mirail, Toulouse,     France 2000 Master’s degree in Neuropsychology, University of Paul Sabatier, Toulouse, France 1999 Bachelor’s degree in Neuroscience, University of Paul Sabatier, Toulouse, France

Scientific summary

The DEVIN team is a translational neuroimaging team built around two poles: methodological development and clinical validation. Neuroimaging is the thematic research core around which different areas of clinical validation gravitate. During these last 5 years, the relationships within the team led to both methodological (e.g., definition of high spatial resolution brainstem sequences) and clinical studies (e.g., multimodal MRI in multisystem atrophy). The methods developed have been used in different clinical areas. For example, multimodal MRI has been methodologically enriched over the years and has been used in patients with Parkinson's syndromes as well as children with neurofibromatosis type 1. The preclinical aspect has strengthened and evolved. Post-mortem sequences for the animal brain were validated and many animals brain were scanned (eg., dog, sheep, horse, cat). Some new areas of clinical validation have been explored in our neuroimaging unit in the last five years: e.g. severe depression, learning disabilities, comatose patients. In summary, the relationships between the methodology and clinical validation parts is a successful one, as shown by the number of scientific papers signed as first or last author from the member of the team(156). New team-wide projects were planned within collaboration between research axes which emerged in recent years.

The team was actively involved in hosting many medical interns and trainees. The main recommendation from the last evaluation pointed to a lack of post-docs and a lack of Inserm recruitment. The number of post-doc increased during this last five years. The team grew up but mainly thank to clinicians. The main objective of our future team will be to recruit new engineers and researches.

 

Follow @PatricePeran

 

~Publications (Feb 2022)~

Total publications (pubmed): 103

H index (google scholar) : 34

Some publications :

De Barros A, Arribarat G, Lotterie JA, Dominguez G, Chaynes P, Péran P. Iron distribution in the lentiform nucleus: A post-mortem MRI and histology study. Brain Struct Funct. 2021 Mar;226(2):351-364.

Péran P, Malagurski B, Nemmi F, Sarton B, Vinour H, Ferre F, Bounes F, Rousset D, Mrozeck S, Seguin T, Riu B, Minville V, Geeraerts T, Lotterie JA, Deboissezon X, Albucher JF, Fourcade O, Olivot JM, Naccache L, Silva S. Functional and Structural Integrity of Frontoparietal Connectivity in Traumatic and Anoxic Coma. Crit Care Med. 2020 Aug;48(8):e639-e647.

Arribarat G, Pasternak O, De Barros A, Galitzky M, Rascol O, Péran P. Substantia nigra locations of iron-content, free-water and mean diffusivity abnormalities in moderate stage Parkinson's disease. Parkinsonism Relat Disord.2019 Aug;65:146-152.

Péran P, Barbagallo G, Nemmi F, Sierra M, Galitzky M, Traon AP, Payoux P, Meissner WG, Rascol O. MRI supervised and unsupervised classification of Parkinson's disease and multiple system atrophy. Mov Disord. 2018 Apr;33(4):600-608. doi: 10.1002/mds.27307.

de Pasquale F, Della Penna S, Sabatini U, Caravasso Falletta C, Péran P.The anatomical scaffold underlying the functional centrality of known cortical hubs. Hum Brain Mapp. 2017 Jul 6

Silva S, de Pasquale F, Vuillaume C, Riu B, Loubinoux I, Geeraerts T, Seguin
T, Bounes V, Fourcade O, Demonet JF, Péran P. Disruption of posteromedial large-scale neural communication predicts recovery from coma. Neurology. 2015 Dec 8;85(23):2036-44.

Nemmi F, Sabatini U, Rascol O, Péran P. Parkinson's disease and local atrophy in subcortical nuclei: insight from shape analysis. Neurobiol Aging. 2015 Jan;36(1):424-33.

Nemmi F, Saint-Aubert L, Adel D, Salabert AS, Pariente J, Barbeau EJ, Payoux P, Péran P. Insight on AV-45 binding in white and grey matter from histogram analysis: a study on early Alzheimer's disease patients and healthy subjects. Eur J Nucl Med Mol Imaging. 2014 Jul;41(7):1408-18.

de Pasquale F, Sabatini U, Della Penna S, Sestieri C, Caravasso CF, Formisano R, Péran P. The connectivity of functionalcores reveals different degrees of segregation and integration in the brain atrest. Neuroimage. 2013 Apr 1;69:51-61.

Péran P, Cherubini A, Assogna F, Piras F, Quattrocchi C, Peppe A, Celsis P, Rascol O, Démonet JF, Stefani A, Pierantozzi M, Pontieri FE, Caltagirone C, Spalletta G, Sabatini U. Magnetic resonance imaging markers of Parkinson's disease nigrostriatal signature.Brain. 2010

Cherubini A, Péran P, Caltagirone C, Sabatini U, Spalletta G. Aging of subcortical nuclei: microstructural, mineralization and atrophy modifications measured in vivo using MRI. Neuroimage. 2009 Oct 15;48(1):29-36.

 Péran P, Cherubini A, Luccichenti G, Hagberg G, Demonet JF, Rascol A, Celsis P, Caltagirone C, Spalletta G, Sabatini U. (2009). Volume and iron content in basal ganglia and thalamus. Hum Brain Mapp. 2009 Jan 26

Péran P, Hagberg G, Luccichenti G, Cherubini A, Brainovich V, Celsis P, Caltagirone C, Sabatini U. Voxel-based analysis of R2* maps in the healthy human brain. J Magn Reson Imaging. 2007 Dec;26(6):1413-20.

Péran P, Rascol O, Démonet JF, Celsis P, Nespoulous JL, Dubois B, Cardebat D Deficit of verb generation in nondemented patients with Parkinson's disease. Mov Disord 2003 Feb;18(2):150-6

~Invited conferences~

2016 - 26 november – OHBM 2nd Alpine Chapter symposium Do multimodal MRI parameters enhance the diagnostic accuracy of Parkinson's disease and atypical parkinsonism? Salzburg (Austria)

2016 - 8-10 June - Congrès de Psychiatrie et Neurologie de Langue Française L’IRM multimodale : applications en psychiatrie Toulouse (France)

2015 - 13 november - Course Report: Bridges and Boundaries in Movement Disorders: The Role of Neuroimaging Multimodal MRI in Parkinson’s disease and parkinsonian syndromes Pisa (Italy)

2015 - 20-23 June- 1st Congress of the European Academy of Neurology, Multimodal MRI markers discriminate Parkinson’s disease from multiple system atrophy patients. Berlin (Germany)

2012 -19-20 March - 4th International congress on multiple system atrophy, MRI multimodal approach: a valuable marker of MSA? Toulouse (France)

2006 - 18-20 october 2nd Meeting of the European Societies of Neuropsychology, Semantic of Action and Mental Representation of Action: common neural substrates? Toulouse (France)

2004 - 24-27 October - Mental dysfunction in Parkinson’s disease Verb Processing In Parkinson ‘s Disease And Huntington’s Disease Salzburg (Austria)

~International cooperation~

 - Radiology translationnal research, Santa Lucia Fundation, Roma , Italy (Pr Sabatini,Dr. F. de Pasquale)

- Neuroimaging Research Unit, Institute of Neurological Sciences, National Research Council, Germaneto, Italy (Dr. A. Cherubini).

- Neurology Department of University Hospital “Marqués de Valdecilla” Santander, Spain (Dr. M. Sierra).

 

~Covers~

 

~Videos~