CV Science

Vincent Legagneux PhD Biological Sciences

Course and current status

Education

• 1985: Master (ex DEA) in Virology (Université Paris 7 & Institut Pasteur) - Supervisor: Pr. D. Paulin - Title: Expression of Vimentin gene in Burkitt's lymphoma.
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• 1986-1990: PhD in Biological Sciences (University Paris 7), speciality: Virology - Supervisors: Pr. Michel Morange and Dr. Olivier Bensaude (Institut Pasteur) - Title: Two biochemical studies of the stressed cell in mammals: Increased turnover of HSP90 phosphate groups; Stimulation of two protein-kinases: A RNA Polymerase II CTD-kinase and a kinase related to CDC2.
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Post-doctoral Experience

• 1990-1992: Postdoctoral Researcher - CNRS - Université de Rennes1 (URA256, PI: Dr. H. Beverley Osborne) - Theme: Post-Transcriptional regulations and Development.
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• 1992-1997: INSERM researcher - CNRS - Université de Rennes1 (URA256, UPR41, PI: Dr. H. Beverley Osborne) - Theme: Post-Transcriptional regulations and Development.
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• 1998-2000: INSERM researcher - CNRS - Université de Rennes1 (UPR41, PI: Pr. Katerine Le Guellec) - Theme: Chromosome dynamics in mitosis.
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• 2000-2004: INSERM researcher - CNRS - Université de Rennes1 (UMR6061, PI: Dr. H. Beverley Osborne) - Theme: Chromosome dynamics in mitosis.
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• 2004-2009: INSERM researcher - CNRS - Université de Rennes1 (UMR6026, PI: Pr. Gilles Salbert) - Theme: Spatial organization of the genome and transcriptional control of gene expression.
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• 2004-2009: INSERM researcher - CNRS - Université de Rennes1 (UMR6061, PI: Dr. H. Beverley Osborne) - Theme: Post-transcriptional control of gene expression.
  19800313 US7863413 US20130004991


• 2010-2015: INSERM Researcher - CNRS - Université de Rennes 1 - IGDR (UMR6061, UMR6290, PI: Pr. Luc Paillard)- Theme: Post-Transcriptional regulations in Pathology and Development.
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• 2016-: INSERM Researcher - INSERM - Université de Rennes 1 - IRSET (UMR1085, PI: Dr. Nathalie Théret) - Theme: Dynamics of Cellular Microenvironment and Communication.
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Links: ORCID Scholar ResearcherID

Research Administration

• 2004-2007: Elected member of Rennes-1 University scientific board


• 2004-2008: Elected member of the CNRS scientific section 26 (Development, Evolution, Reproduction, Aging)


• 2008-2012: Elected member of Rennes-1 University board


• 2016-2018 : Elected member of INSERM specialized scientific comitee CSS3 (System Physiology and Physiopathology)

Scientific summary

Scientific interests: Gene expression control, Development and homeostasis, Cellular micro-environment.

Until recently, I focused my research on post-transcriptional controls of gene expression during embryonic development. I have characterized the role of the RNA-binding protein CELF1 (previously known as EDEN-BP) in regulating the polyadenylation state, translation and stability of maternal mRNAs in amphibian embryos.

Among the maternal mRNAs controlled by CELF1, I focused my attention on one encoding pEg7/NCAPD2, a non-SMC subunit of the Condensin complex. I have shown that NCAPD2 plays a crucial role in the dynamics of both meiotic and mitotic chromosomes. Beside this, I showed in collaboration with Raphael Métivier, that Cohesin (a complex related to Condensin) is required for the spatial remodeling of the genome upon transcriptional response to estrogens.

More recently, I studied the role of CELF1 in later developmental stages and in tissue homeostasis. Celf1_KO mice exhibit a severe cataract and, based on this finding, I was involved in a project aiming to decipher the role of CELF1 in lens, in collaboration with the Salil Lachke's group (University of Delawware). Beyond this collaborative work, I have identified by RNA-seq the mRNAs whose expression is controlled by CELF1 in lens, and more specifically those regulated at the level of pre-mRNA splicing.

In 2016, I joined the team leaded by Nathalie Theret, whose aim is to decipher the role of adamalysins in TGF-β activity in chronic liver diseases (Fibrosis and Cellular Hepatocarcinoma). For this project, we implement complementary approaches such as cell biology, biochemistry, functional genomics, system biology and modeling.