Scientific topics
Keywords
ITMO
Agathe Subtil PhD Cell biology
Course and current status
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Current Position: |
Director of research (CNRS).Head of the laboratory Cell biology of microbial infection, Institut Pasteur |
Education:
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2004 1996 |
Habilitation à diriger des recherches from the University Paris 5 PhD in Cell Biology from the University Paris 6
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Professional Experience:
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since 2014 2005-14 2000 1997-9 1993-6
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Head of the Laboratory “Cell biology of microbial infection”, Institut Pasteur Principal Investigator of the “Chlamydia” team, Unit Biology of cellular interactions, Institut Pasteur, Paris Chargée de Recherche, Centre National de la Recherche Scientifique (CNRS). Postdoctoral Research Scientist at Cornell Medical College, New York, USA. Research subject: regulation of glucose transport PhD in Cell Biology at the Institut Pasteur, Paris Research subject: intracellular transport of the interleukin-2 receptor |
Scientific summary
The goal of the work of the laboratory is to gain knowledge on the normal behavior of the eukaryotic cell, and on its disruptions during an infectious process. We focus on the mechanisms of entry and intracellular fate of intracellular bacteria, Chlamydia. Chlamydiae species pathogenic to humans, mainly Chlamydia trachomatis and Chlamydia pneumoniae, cause a number of diseases, including trachoma, pelvic inflammatory disease and pneumonia. Primary infections are often minor or asymptomatic; the consequences appear long after infection. Throughout their cycle in the host cell, chlamydiae remain in a membrane-bound compartment called an inclusion. We investigate the interactions between the bacteria and the cells during infection. We focus mainly on the functional study of proteins secreted by the bacteria into the host cytoplasm by a process called type III secretion.
