CV Science

Sebastien LEON PhD (Ecole Nationale Supérieure d’Agronomie de Montpellier)

Course and current status

10/2000-10/2002 : PhD from Ecole Nationale Supérieure d’Agronomie de Montpellier ; UMR5004 CNRS/INRA/AgroM/UM2– Montpellier, France. Advisor : Dr J-F Briat : «Characterization of Arabidopsis thaliana genes involved in Fe-S clusters assembly»

10/2002-04/2006 : Post-doctoral fellow — Dr Subramani’s lab, UC San Diego, CA, USA. Topic : Role of ubiquitin in peroxisome biogenesis

04/2006-10/2008 : Post-doctoral fellow — Dr Haguenauer-Tsapis’ lab, Institut Jacques Monod, Paris, France. Topic : Substrate specificity of the ubiquitin ligase Rsp5 in membrane trafficking.

10/2008-09/2012 : Staff researcher (CR2 CNRS) — Dr Haguenauer-Tsapis’ lab, IJM, Paris

10/2012-10-2016 : Staff researcher (CR1 CNRS) and Junior group leader, IJM, Paris. Team "membrane trafficking, ubiquitin and signaling".

10/2016-present : Research director (DR2 CNRS) and Group leader, IJM, Paris.

Scientific summary

We are interested in understanding the molecular mechanisms leading to cell adaptation in the face of a fluctuating environment.

Our prime interest is to understand how cells cope with glucose presence or limitations, particularly in terms of nutrient transporter expression, trafficking and endocytosis. We notably focus on the contribution of signaling pathways and ubiquitin in this process.

Our model organism is the budding yeast, Saccharomyces cerevisiae.

keywords : cell biology, nutrient transporters, trafficking, endocytosis, ubiquitin, arrestin-related proteins, Rsp5/Nedd4, glucose signaling, glucose metabolism, yeast

ResearchGate: https://www.researchgate.net/profile/Sebastien_Leon2