CV Science

Maude LE GALL PhD Life Science, Physiologist

Course and current status

Maude Le Gall studied Molecular and Cellular Biology at the Ecole Normale Superieure of Lyon (France) and completed her PhD in biology in Jacques Pouyssegur’s lab in Nice (France).

She then moved to Seattle (US) to perform a 4-year postdoctoral training at the Fred Hutchinson Cancer Research Center.

She came back to France in 2003, was nominated as a Research Associate at Inserm in 2005 and developed projects on intestinal sugar transport focusing on the GLUT2 transporter.

In 2012, she moved at the Bichat Hospital in Paris (France) where she  developed a new research project dealing with the impact of bariatric surgery on intestinal remodeling focusing on enteroendocrine cells and nutriment transport and metabolism. She was nominated as a Research Director at Inserm in 2018

Since 2019 she co-leads with André Bado a research team entitled PIMS for Plasticity of Intestinal Mucosa in response to Surgeries

Education:

2010   Accreditation to Supervise Research (HDR) University Pierre and Marie Curie, Paris, France

1999   Ph.D. in Life Science, University of Nice-Sophia Antipolis, France

1995   Magister in Molecular and Cellular Biology, Ecole Normale Supérieure of Lyon, France

Research experience:

Present position (since 2019):

Research Director (DR2) Inserm and co-team leader with Dr A. Bado “Plasticity of Intestinal Mucosa in response to Surgeries” Inserm UMRS1149 Center for Research on Inflammation (CRI), Paris, France

Previous appointments 

2012-2018 Senior Research Associate (CR1) Inserm in Team 1 directed by Dr A. Bado “Digestive Physiology and Endocrinology” Inserm UMRS1149 Center for Research on Inflammation (CRI), Paris, France

2005-2012 Research Associate (CR1) Inserm in Team 9 co-directed by Drs A. Leturque and E. Brot-Laroche “Physiopathology of sugar transport and detection” Inserm UMRS872 Cordeliers Research Center, Paris

2003-2005 Postdoctoral fellow, Dr. J. Chambaz’s laboratory “Glucose sensing pathways downstream GLUT2 in enterocytes and hepatocytes” Inserm U505 Cordeliers Research Center, Paris

1999-2003 Postdoctoral fellow, Dr E. Giniger’s laboratory, “Control of axon guidance by different Notch pathways in Drosophila” Fred Hutchinson Cancer Research Center, Seattle, USA

1995-1999 Graduate student, Dr J. Pouysségur’s laboratory, “Anchorage role in survival and proliferation of fibroblastic cells” CNRS UMR6543, Nice, France

Teaching activities:  Lecturer in Master 2 and Master 1 at University of Paris Diderot, University Pierre & Marie Curie, and Ecole Pratique des Hautes Etudes (25 hours per year)

Elected Member of Councils:

Scientific Council of Paris Diderot’s Faculty of Medicine (2013-2017, 2018-2020);

Administrative Council of Inserm (2013-2017, 2017-2021),

Specialized Scientific Council of Inserm (2008-2012)

Awards and Fellowships

2019 : Research Fellowship from the Fondation de l'Avenir

2019 : Research Fellowship from the Société Francophone du Diabète

2016 : Benjamin Delessert Award for Research in Nutrition

2016 : Research Fellowship from the Société Francophone du Diabète

2015 : Research Prize from the French Society of Clinical Nutrition and Metabolism (SFNCM)

Publications See orcid.org/0000-0002-5372-4585

Scientific summary

Our team combines researchers, physicians and surgeons. It is internationally recognized for its expertise in gut physiology and pathology.

Since 2012, we focused on intestinal adaptations either in the context of over- or under-nutrition, more specifically we deciphered mechanisms of gastrointestinal adaptations in response to weight-loss surgical therapies (bariatric surgeries) and massive intestinal resection, main cause of intestinal failure (short bowel syndrome).

I focus on intestinal adaptation in response to bariatric surgery in strong association with two digestive surgery units (Bichat & L Mourier hospitals), European leaders in bariatric surgeries. Together we developed animal models of bariatric surgery; Sleeve, Roux-en-Y Gastric Bypass (RYGB) and One Anastomosis Gastric Bypass (OAGB) and characterized the impact of bariatric surgery on intestinal remodeling focusing on nutrient transport and metabolism. Combining experimental research in these preclinical models with clinical studies, we identified differences in alimentary glucose absorption and intestinal blood glucose handling after RYGB versus Sleeve (Gastroenterology, 2016). We also characterized the protein malabsorption and oesophagus reflux after the controversial OAGB (AJP Gastrointest Liver Physiol. 2016, Obes. Surg. 2017, AJP Gastrointest Liver Physiol. 2019)