CV Science

Wilfried LE GOFF Ph.D. Molecular and Cell Biology of Lipids in Cardiometabolic Diseases

Course and current status

EDUCATION:

2015 : Accreditation to supervise research (HDR) - Pierre & Marie Curie University, UPMC.

1999-2002 : Ph.D. in Cellular and Molecular Physiopathology - Pierre & Marie Curie University, UPMC.

1997-1998 : Master's degree in Cellular and Molecular Physiopathology - Pierre & Marie Curie University, UPMC.

POSITIONS:

2019-Present : Director of Team 4 SLIM : Systemic and Cellular Lipid Metabolism in Cardiometabolic diseases, Sorbonne Université / INSERM UMR_S1166 ICAN (Director: Stéphane Hatem), Paris, France.

 2018-Present : Member of the Research Committee of Sorbonne Université, Paris France. 

2016-2017 : Member of the Research Committee of the Pierre & Marie Curie University, Paris France. 

2019-Present : Member of the Council of the ICAN Institute Hospitalo-Universitaire (IHU), Paris France. 

2018-Present : Member of the Executive Committee of the UMR_S1166 ICAN Paris France.

2018-Present : Member of the contractual activities advive of Sorbonne Université, Paris France. 

2017-Present : Member of the Scientific Council of the Doctoral School "Physiology, Physiopathology and Therapeutic" (P2T) (ED394), Sorbonne Université, Paris France. 

2014-2018 : Senior Research Investigator, UPMC / INSERM ICAN UMR_S1166 (Director: Stéphane Hatem), Team 4 : «Integrative Biology of Atherosclerosis», Hôpital de la Pitié, Paris, France. Director: Philippe Lesnik, Ph.D. 

2009-2013 : Research Investigator, INSERM, UMR939, «Dyslipidemia, Inflammation and Atherosclerosis in metabolic diseases», Hôpital de la Pitié, Paris, France.             Director: M. John Chapman, Ph.D., D.Sc. 

2005-2008 : Junior Research Investigator, INSERM, Unit 551, Pitié-Salpétrière Hospital, Paris, France. Director: M. John Chapman, Ph.D. 

2003-2005 : Postdoctoral fellow at the Cleveland Clinic Foundation, Lerner Research Institute, Department of Cell Biology, Cleveland, OH, USA. Laboratory of Jonathan D. Smith, Ph.D.

Scientific summary

ResearcherID: N-6326-2017 (http://www.researcherid.com/rid/N-6326-2017)

ORCID: (http://orcid.org/0000-0002-7611-9644)

Wilfried Le Goff's group works on mechanisms controlling lipid homeostasis and inflammation in macrophages in cardiometabolic diseases.
Macrophages (resident and inflammatory) play a central role in the chronic lipid-inflammatory dimension of cardiometabolic diseases (CMD). Alteration of lipid metabolism in those disorders allows macrophages to engulf excess of cellular material and to handle large amounts of lipids. Interestingly, the fate of such lipids within macrophages is a key sensor in the activation of those cells. Indeed, in response to a lipid-stress, tissue macrophages trigger an adaptive program to resolve the local inflammation and restore lipid homeostasis in the tissue altered. In this context, his group is interested in decrypting the adaptive program triggered by tissue macrophage in response to lipid stress. To achieve this goal, Omic approaches (lipidomic and transcriptomic) are combined in order to identify interaction networks in tissue macrophages in CMD and to propose potential new therapeutic targets. His studies are based on integrated in vitro and in vivo approaches combining molecular and cellular biology investigations, studies in mouse models and translation in CMD patients.