Scientific topics
Keywords
ITMO
Dominique PIDARD PhD (Doctorat d'Etat ès-Sciences) in Life Sciences, Paris - Pierre et Marie Curie University (1985)
Course and current status
• Postgraduate student, Paris - Denis Diderot University, and Inserm U150 / CNRS LA334 "Hemostasis and Experimental Thrombosis", Paris, France | 1979-09-01 to 1981-08-31
• Research Assistant, Research Department, The Blood Center of Southeastern Wisconsin, Milwaukee, WI, USA | 1981-12-01 to 1983-02-28
• PhD student, Paris - Pierre et Marie Curie University, and Inserm U150 / CNRS LA334 "Hemostasis and Experimental Thrombosis", Paris, France | 1983-03-01 to 1985-03-31
• Researcher (Chargé de recherche), CNRS, Paris, France | 1985-04-01 to present, in five consecutive parisian Inserm - CNRS - University research laboratories, mostly on biomedical locations (Lariboisière Hospital, Saint-Louis Hospital,The Pasteur Institute, Bichat Hospital, and Paris Faculty of Pharmacy)
Scientific summary
1979 – 1989 | Identification, and analysis of the structure and biological activity of membrane receptors involved in the mechanisms of adherence and activation of human blood platelets, normal or from patients with inherited thrombopathies, during the pathophysiological process of hemostasis and thrombosis (including the αIIbβ3 integrin and the GPIb-V-IX complex)
1990 – 1996 | Study of the interactions between human blood platelets, leukocytes and endothelial cells during hemostatic and thrombo-inflammatory processes, with emphasis on the roles of leukocytic and plasma proteinase systems, as effectors in these interactions via the proteolytic regulation of rmembrane receptors (including the αIIbβ3 integrin and the GPIb-V-IX complex)
1996 – 2006 | Study of the interactions between human leucocytes (monocytes and polymorphonuclear neutrophils), epithelial cells and bacterial pathogens during the acute inflammatory response to infection in the respiratory tratc, with emphasis on the roles of the host inflammatory proteinase systems and of the bacterial proteinases, as effectors in these interactions via the proteolytic regulation of rmembrane receptors (including the αIIbβ3 integrin, the G protein-coupled and proteinsae-activated receptors PAR-1 et PAR-2, and the integrin-associated urokinase receptor uPAR)
2006 – 2013 | Study of the interactions between the inflammatory proteinase systems, including bacterial proteinases, and proteinase-regulated receptors (including uPAR, integrins, and cadherins) in human vascular cells (including smooth muscle cells, myofibroblasts and endothelial cells), with emphasis on the roles of these interactions in alteration of cell adherence and survival
2014 – 2016 | Study of the mechanisms implicated in recruitment, survival and differentiation of vasculogenic stem and progenitor cells during vascular and tissue repair
Since 2017 | Study of the mechanisms implicated in the terminal differentiation of human bone marrow megakaryocytes and their production of blood platelet, with emphasis on the identification and analysis of gene mutations leading to inherited familial macrothrombocytopenia
