CV Science

christophe SIRAC PhD Immunology, Full Professor

Course and current status

CNRS UMR 7276 INSERM UMR 1262

Contrôle de la réponse immune B et lymproliférations (CRIBL) (Director : Pr Michel Cogné)

CRBS, room 210 – 2, rue du Dr Marcland 87000 Limoges – France

Phone: 33 (0) 519 564 213

Fax : (33)(0) 555 435 897

@-mail: christophe.sirac@unilim.fr

Education

1998-1999          Master’s degree in immunology with honours (University of Poitiers, France)

1999-2003          PhD in Immunology (University of Limoges, France) : “Concerted regulation of immunoglobulin chain expression and consequences in pathology” (Director Michel Cogné, CNRS UMR 6101)

2016                     HDR (French Habilitation to Conduct researches): “Late maturation of B cells and pathogenicity of monoclonal immunoglobulins”

Positions

2003-2004          Assistant professor, University of Limoges, France

2004-2006          Research assistant, LFB Biotech (French biotech company), Lille, France (optimization of cell lines for the production of therapeutic antibodies)

2006-2019          Associate professor, University of Limoges, France

2018-present      Full professor

Teaching activities, tutoring and memberships

- 2018-2022        In charge of the “Biology and Health Science” master programs at Limoges University

- 2008-2018        Head of the Master program « Biotechnology, Genomics, Biotherapy », University of Limoges, France

- 2006- Now       In charge of several teaching units of B.S and Masters (Immunology, Cell biology, Physiology, Genetics)

- Supervision of 8 master 2 internships, 5 PhDs and 2 post-docs since 2006

- HDR since 2016 (French Habilitation to conduct researches)

- Board of the Doctoral School in biological sciences and health ED615 (Confederal university Leonard de Vinci)

- Member of the French society of Immunology

- Member of the French society of Hematology

- Member of the International research group on Kidney and Monoclonal Gammopathies (IKMG)

- Member of the national Reference Center for AL amyloidosis and other Monoclonal Ig deposition diseases (head: Pr Arnaud Jaccard, University Hospital of Limoges)

Scientific summary

Research activities

My research activity is devoted to B cell immunology and immunopathology. More specifically, I am interested in the regulation of immunoglobulin (Ig) expression and production during B cell development. My contribution to the field encompasses allelic exclusion, RNA surveillance, Ig class switch recombination and plasma cell development. Beside this basic research interest, I also contributed to the characterization of genetic alterations of Ig genes and development of mouse models to study the toxicity of abnormal Ig fragments involved in human diseases related to monoclonal Ig deposition including AL amyloidosis, LCDD/HCDD or renal Fanconi syndrome. On behalf of the National reference center for AL amyloidosis and other monoclonal immunoglobulin diseases, I am in charge of the experimental research. I am also involved in translational science with the development of biotechnology tools and innovative therapeutic molecules for the treatment of AL amyloidosis.

Selected Invited Presentations:

- Race-RepSeq: high throughput sequencing of monoclonal immunoglobulins. C. Sirac. International Kidney and Monoclonal Gammopathy Research Group, 4th international meeting. Mai 23-24, 2019, Montreal, Canada.

- Monoclonal Ig deposition diseases: Of mice and men. C. Sirac. International Kidney and Monoclonal Gammopathy Research Group, 3rd international meeting. Avril 27-28, 2017, New Orleans, USA.

- Mayo Clinic “Grand Rounds” and “Research forum sessions”: Models of Monoclonal gammopathies of renal significance. Rochester, MN, USA, April 2017

- Monoclonal Ig deposition diseases : contributions from experimental models. Seminar Series, Louisiana State University, Shreveport, USA, April, 2015. (Invitation : Pr Guillermo Herrera)