Emmanuel Gautier Phagocytes in cardiometabolic diseases

Course and current status

Oct 2013 - … : CRCN INSERM – Researcher/Group leader at INSERM UMR_S 1166, Pitié-Salpétrière Hospital in Paris.

Jan 2012 - Oct 2013 : Research instructor. Washington University School of Medicine in St Louis, USA (Pr Gwendalyn J. Randolph).

Jan 2008 - Dec 2011 : Post-doctoral fellow. Mount Sinai School of Medicine in New York, USA (Pr Gwendalyn J. Randolph).

Oct 2003 - Jan 2008 : PhD fellow. INSERM U551 in Paris.

Scientific summary

Our group is interested in delineating the role of mononuclear phagocytes (monocytes, macrophages and dendritic cells) in chronic inflammatory disorders such as cardiometabolic diseases (atherosclerosis, obesity, NASH).
More specifically, we study how dendritic cell subsets, tissue resident and monocyte-derived macrophages impact on cardiometabolic diseases development, and develop tools to target these subsets in vivo. Our studies are based on integrated approaches combining molecular, cellular biology and animal models. Particular attention is given to the interactions between inflammatory stimuli, mononuclear phagocytes, lipid and carbohydrate metabolisms as well as the gut microbiota.

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