Karima KISSA-MARIN - CV - PI of the team "Emergence of haematopoietic stem cells and cancer"

E-mail :[email]
Phone : +33 6 27 00 25 08
Location : Montpellier, France

Scientific topics

Biology & Biochemistry
Immunology

Keywords

ITMO

Last update 2020-07-29 07:07:59.357

Karima KISSA-MARIN PI of the team "Emergence of haematopoietic stem cells and cancer"

Course and current status

CURRENT EMPLOYMENT

Since 2012. Researcher (Chargée de Recherche 1), Inserm, UMR 5235, Montpellier, France.

Starting 2013. Atip-Avenir team "Emergence of haematopoietic stem cells and cancer".

EDUCATION

2012. HDR “Habilitation à Diriger des Recherches”, University of Montpellier, France

2009. HEC, Challenge plus, Paris.

2001. Ph.D in Neurobiology and Embryology, National Museum of Natural History - Pasteur Institute, Paris.

1996. M. Sc., Biological Activity of Natural Substances, National Museum of Natural History, Paris VI University.

RESEARCH EXPERIENCE

2007-2011. Researcher (Chargée de Recherche 1), Pasteur Institute, Paris. Lab Head: P. Herbomel. Macrophage and immunity development in the zebrafish embryo. Projects: Origin and behaviour of hematopoietic stem cells.

2003- 2007. Post-doctoral trainee, Pasteur Institute, Paris. Lab Head: P. Herbomel. Macrophage and immunity development in the zebrafish embryo. Projects: Origin of hematopoietic stem cells.

2001-2002. Post-doctoral Fellow, MRC, Centre for Developmental Neurobiology, King’s College, London. UK. Lab Head: Corinne Houart. Project: Patterning and organisation of the anterior neural plate in the zebrafish embryo.

1996-2001. Ph.D, Molecular Embryology Group, URA 1947, CNRS Pasteur Institute, Paris. Lab Head: P. Brulet. Project: Development of new genetic tools to map neuronal circuits in vertebrates.

1996. M. Sc, Institute of Physical and Chemical Biology, INRA-INSERM U 310, Paris. Lab Head: Prof. Debey. Project: Control of the early transcription in one-cell stage mouse embryo.

Scientific summary

Organs are constantly subjected to mechanical forces that influence their development and physiology both in normal and pathological conditions. By using zebrafish embryos as a model, we have recently demonstrated that Hematopoietic Stem Cells (HSCs) emerge directly from the aorta floor through a process called the Endothelial Haematopoietic Transition (EHT).

My hypothesis is that the mechanical stress exerted by the blood flow on the aorta induces a series of morphogenetic signals resulting in the activation of HSC specifying genes and the down-regulation of endothelial vascular identity. This gene expression remodelling is thought to drive the EHT leading to the emergence of HSCs.

We now want to address the molecular and cellular events driving this process.