Stefano Marullo MD, PhD biochemistry

Course and current status

Stefano Marullo, MD, PhD Short CV

Borne in Rome, Italy  (November 3rd, 1955)                               


1987:                        MD Université Paris Diderot.

1990:                        PhD Biochemistry, Université Paris Diderot.


2002-:                       Research Director (INSERM, Except. Class since 2013), Principal Investigator, team “receptor signaling and molecular scaffolds”, Institut Cochin, Paris

2019-:                       INSERM scientific referent at the Université de Paris



1979-1986:            Resident of Paris Hospitals (Internal Medicine, Hematology)

1987-1995:            Associate Physician, Department of Immuno-Hematology St. Louis      Hospital, Paris

1986-1990:            Research Fellow, then Senior Scientist (1988), Laboratory of "Molecular      Biology of Receptors", Institut Pasteur, Paris

1990-1995:            Senior Scientist and Research Director (1992), Laboratory of Molecular                                Immuno-pharmacology, Institut Cochin de Génétique Moléculaire                                        (ICGM), Paris

1995-1997:             Visiting Scientist, Biochemistry Department, Regis Kelly Laboratory,                                    University of California San Francisco, USA

1998-2001:            Principal Investigator, CNRS Laboratory of Cellular and Molecular                                         Pharmacology of Membrane Receptors, ICGM, Paris

2002-2008:             Co-chair Department of Cell Biology, Institut Cochin, Paris

2005-2012:             Associate Professor, Université Paris Descartes

2008-2012:             Vice-Director of the PhD Program (B3MI), Universités Paris Diderot and                                Paris Descartes

2012-2019:             Vice-President for Research, Université Paris Descartes 



1984                          Fellowship, ”Ministère de la Recherche et de l'Enseignement                                               Supérieur”

1987                          Research fellowship, “Fondation pour la Recherche Médicale” (FRM)

1995                          Research fellowship, NATO (visiting scientist)

1996                          Research fellowship, FRM (visiting scientist)

1998-2001                  New-Team Starting Grants: FRM and the Association pour la                                                Recherche sur le Cancer (ARC)

2012-2015              “FRM-team” award



ORCID:  0000-0001-9604-9973


80 original articles in international journals, including: Blood, Cell, EMBO J, J Clin Invest, Mol Cell, Nat Biotechnol, Nat Commun, Nat Immunol, Nat Med, Nat Methods, Mol Psychiatry, PNAS, Science.

31 review/opinion articles, 11 book chapters, (>10.300 citations, HF: 53, Google Scholar; >7.100 citations HF: 44, ISI-WOS)



Emorine et al, Science 245: 1118 (1989)

Marullo S et al, Nat. Biotechnol. 7: 923-927 (1989)

Magnusson Y et al, J Clin Invest, 86: 158 (1990)

Loisel TP et al, Nat Biotechnol, 15:1300 (1997)

Perretti M et al, Nat Med, 8: 1296 (2002)

Bourougaa K et al, Mol Cell, 38:78 (2010)

Coureuil M et al, Cell, 143:1149 (2010)

Bernard S et al. Nat Med, 20:725–731 (2014)

Lima-Fernandes E et al. Nat Commun, 5:4431 (2014)

Doly S et al., Mol. Psychiatry 21:480-490 (2016)

Maïssa N. et al. Nat Commun, 8:15764 (2017)

Virion Z. et al. Nat Commun, 10:4752 (2019).



1988: US 88. 03475; accepted US 5.242.822 (1993), UE 89 400 768.1.(1994) ; licensed 1989

1989: 89.00918 accepted UE 04.55.682 (1993), US 5.288.607 (1994), JPN 3050238 (2000); licensed, 1996, 2000.

1994: 94.04861

1997: 97.04476; extension UE JPN (100-999); accepted US 6.713.278; licensed 2002, 2009

2001: US 10/38.010, licensed, 2001.

2011: UE 10306215.4


Participation in permanent evaluation committees

1995-1998          Member of the INSERM Study-Section Endocrinology/Reproduction 

1997-2001          Member of the Scientific Council of “CHU Cochin-Port Royal”, University Paris Descartes.

2004-2008          Member of the Scientific Board of the Ville de Paris

2000-:                   Member of the Scientific Board of the "INSERM Workshops"

2009-2019          Member of the Scientific Board of the Ligue Contre le Cancer, comité de l’Oise

2014-2020           Member of the Research Council, Université Libre de Bruxelles, Belgium




Am J Physiol, BBRC, Biochemistry, Blood, Cardiovasc Res, Cell, Cells, EMBO, EMBO Rep, FEBS letters, IJMS, J Biol Chem, J Cell Sci, MolPharmacol, Nature, Nat Med, Nat Methods, Neurochem, PlosPathogens, PNAS, Sci Reports, Traffic, Trends Mol Med, Trends Pharmacol Sci.



Université Libre de Bruxelles (Belgium), FRQS, FCI, Génome Québec, McGill University, Toronto University (Canada), MRC, Wellcome Trust Fund, BSSRC (UK), NHMRC, Raine Foundation (Australia), Swiss National Science Foundation, Geneva University (Suisse), Human Frontieres (Intl.), Ministère de la Recherche, Ville de Paris, ANR, AERES/HCERES (France).



2020-      Editorial Board Member, Section Board for 'Molecular Pharmacology', International Journal of Molecular Science.



2015, 2017, 2019, 2021 Agence Nationale pour la Recherche (ANR)

2010, Ligue contre le Cancer

2013, Equipe FRM

2014, Institut National du Cancer (INCA)

2018, Vaincre la Mucoviscidose

2021, Pre-maturation Grant, Idex, Université de Paris

Scientific summary

G protein coupled receptors (GPCRs), the largest family of membrane receptors, are implicated in a wide range of human diseases. Signal outputs resulting from their activation depend on their subcellular location and their local interacting partners, among which beta-arrestins (barrs) play a major role. Our project focuses on emerging paradigms of regulated GPGR and barr subcellular trafficking, from mechanistic molecular aspects to physiology and pathology.

The principal specific aims of our project are (Project Leaders):
-Deciphering cellular and molecular mechanisms involved in regulated GPCR export to the cell surface; pathophysiological implications (S Marullo)
-Investigating molecular basis of the interaction between pathogens and receptors for cell adhesion and signaling (S Marullo)
-Exploring mechanisms and functions of the nuclear trafficking of the regulatory scaffolding proteins barrs (H Enslen, M Scott)
-Deciphering new GPCR/barr-dependent mechanisms that regulate cell adhesion (H Enslen)
-Studying GPCR/barr-dependent mechanisms that regulate the anti-oncogenic PTEN phosphatase functions (M Scott)

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