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My main scientific achievements are: 1) discovery of the spike timing-dependent plasticity (STDP) rules in the hippocampus in vitro (Debanne et al., PNAS 1994; Debanne et al., PNAS 1996; Debanne et al., J Neurophysiol., 1997; Debanne et al., J Physiol. 1998; Debanne et al., J Neurosci. 1999; Inglebert et al., PNAS 2020; Debanne & Inglebert, Curr Opin Neurobiol 2023), 2) mechanisms of short-term synaptic plasticity at unitary synapses (Debanne et al., J Physiol. 1996), 3) characterization of propagation failures along the axon (Debanne et al., Nature 1997; Kopysova & Debanne, J Neurosci. 1998), 4) Hebbian plasticity of intrinsic excitability (Daoudal et al., PNAS 2002; Campanac & Debanne, J Physiol., 2008; Campanac et al., J Neurosci. 2008; Campanac et al., Neuron 2013; Incontro et al., J Neurosci 2021; Sammari et al., PNAS 2022), 5) mechanisms and plasticity of neuronal timing (Sourdet et al., J Neurosci. 2003; Boudkkazi et al., Neuron 2007; Cudmore et al., J Neurosci. 2010; Boudkkazi et al., J Physiol. 2011, Gastrein et al., J Physiol 2011; Campanac et al., Neuron 2013) and 6) the role of axonal ion channels in information processing (Rama et al., Nat Commun 2015, Zbili et al., Sci Adv 2020; Zbili et al., PNAS 2021).
My current reseach is focussed on 1) the mechanisms of long-lasting, plasticity of intrinsic excitability in cortical and subcortical neurons, 2) the mechanisms of amblyopia, 3) the role of axonal ion channels in information processing and 4) spike-timing-dependent plasticity (STDP) rules in physiological conditions.
To address these questions, we employ 1) multiple whole-cell patch-clamp recordings in brain slices (from two connected neurons or from the axon / cell body), 2) laser scanning microscopy imaging (Ca2+, Na+, voltage), 3) computer modeling, 4) hybrid neuron-computer techniques (dynamic-clamp, hybrid networks) and 5) molecular tools (single neuron electroporation in slice cultures).
Supported by CNRS, INSERM, ANR, FRM, A*Midex, Ministry of Research & Région SUD.
Main publications as senior author (2013-present):
Debanne D & Inglebert Y (2023) Spike-timing-dependent plasticity and memory. Current Opinion in Neurobiology 80: 102707
Sammari M, Inglebert Y, Ankri N, Russier M, Incontro S & Debanne D (2022) Theta patterns of stimulation induce synaptic and intrinsic potentiation in O-LM interneurons. Proceedings of the National Academy of Sciences USA. 119: e2205264119
Zbili M, Rama S, Benitez MJ, Fronzaroli-Molinieres L, Bialowas A, Boumedine-Guignon N, Garrido JJ & Debanne D (2021) Homeostatic regulation of axonal Kv1 channels accounts for both synaptic and intrinsic modifications in the hippocampal CA3 circuit. Proceedings of the National Academy of Sciences USA. 118: e2110601118.
Incontro S, Sammari M, Azzaz F, Inglebert Y, Ankri N, Russier M, Fantini J & Debanne D (2021) Endocannabinoids tune intrinsic excitability in O-LM interneurons by direct modulation of postsynaptic Kv7 channels. Journal of Neuroscience 41: 9521-9538.
Fékété A, Ankri N, Brette R & Debanne D (2021) Neural excitability increases with axonal resistance between soma and axon intial segment. Proceedings of the National Academy of Sciences USA. 118: e2102217118.
Inglebert Y, Aljadeff J, Brunel N & Debanne D (2020) Synaptic plasticity rules with physiological calcium levels. Proceedings of the National Academy of Sciences USA. 117: 33639-33648.
Zbili M, Rama S, Yger P, Inglebert Y, Boumedine-Guignon N, Fronzaroli-Molinieres L, Brette R, Russier M & Debanne D (2020) Axonal Na+ channels detect and transmit levels of input synchrony in local brain circuits. Science Advances 6: eaay4313.
Debanne D, Inglebert Y & Russier M (2019) Plasticity of intrinsic neuronal excitability. Current Opinion in Neurobiology 54: 73-82.
Seagar M, Russier M, Caillard O, Maulet Y, Fronzaroli-Molinieres L, De San Feliciano M, Boumedine-Guignon N, Rodriguez L, Zbili M, Usseglio F, Formisano-Tréziny C, Youssouf F, Sangiardi M, Boillot M, Baulac S, Benitez MJ, Garrido JJ, Debanne D, El Far O (2017) LGI1 tunes intrinsic excitability by setting the density of axonal Kv1 channels. Proceedings of the National Academy of Sciences USA 114: 7719-7724.
Rama S, Zbili M, Bialowas A, Fronzaroli-Molinieres L, Carlier E, Marra V & Debanne D (2015) Presynaptic hyperpolarization induces a fast analogue modulation of spike-evoked transmission mediated by axonal sodium channels. Nature Communications 6: 10163.
Campanac E, Gasselin C, Baude A, Rama S, Ankri N & Debanne D (2013) Enhanced intrinsic excitability in basket cells maintains excitatory-inhibitory balance in hippocampal circuits. Neuron 77: 712-722.
Debanne D, Bialowas A & Rama S (2013) What are the mechanisms for analogue and digital signaling in the brain? Nature Reviews Neuroscience 14: 63-69.