Dominique Debanne
  • E-mail :[email]
  • Phone : +33 4 91 69 87 45
  • Location : Marseille, France
Last update 2021-11-22 12:51:42.168

Dominique Debanne PhD Neuroscience

Course and current status

Current status

  • Head of UNIS (INSERM-AMU research unit, since 2012)
  • Group leader (since 1998)
  • CNRS Research Director (DR1)

 

Degrees

  • 1992: PhD in Neuroscience Université Pierre et Marie Curie
  • 2000: Habilitation Université Pierre et Marie Curie

 

Career

  • 1988-1992: PhD fellow, Neurobiologie et Neuropharmacologie du Développement, Orsay
  • 1992-1996: Post-doc fellow, Brain Research Institute, University of Zurich (Switzerland)
  • 1996-2001: CNRS Research Associate (CR2)
  • 1998-2000: Group leader, Unité de Neurocybernétique Cellulaire, UPR9041 CNRS, Marseille
  • 2001-2005: AVENIR team leader, Neurobiologie des Canaux Ioniques, U464-U641, INSERM, Université de la Méditerranée, Marseille
  • 2001-2004: CNRS Research Associate (CR1)
  • 2004-2010: CNRS Research Director (DR2)
  • 2010-present: CNRS Research Director (DR1)
  • 2012-present: Head of UNIS, UMR 1072 INSERM - Aix-Marseille Université

 

Awards and honours

  • 2000-2003: ACI young investigator (French Ministry of Research)
  • 2001-2005: AVENIR INSERM team leader
  • 2010-2013: Scientific Excellence Award (PES, CNRS)
  • 2019-2022: FRM Equipe 2018

 

Current research grants

  • ANR LoGiK (2017-2022)
  • FRM Equipe (2019-2022)
  • ANR Plastinex (2021-2025)

 

Grant and scientific committees

  • McGill University (Canada), IN Shangaï (China), DFG (Germany), NOHRD (Netherlands), Research Council Norway (Norway), NMRC (Singapore), ETH Zurich (Switzerland), FNS (Switzerland), Welcome Trust (UK), MRC (UK)
  • National Science Foundation (USA)
  • Brain-I-Net (EC), FP6 (EC)
  • ANR (2007, 2015, 2021; France), AERES (2008; France), CoNRS section 25 (2012-2013; France)
  • AMiDEX (2020; Marseille)

 

Executive committees

  • INSERM Units of Luminy - TPR2
  • FHU Epinext
  • Neuroschool (Aix-Marseille University)
  • NeuroMarseille

 

Member of Editorial Boards

  • Journal of Physiology (2005-2012)
  • European Journal of Neuroscience (2008-2011)
  • Frontiers in Cellular Neuroscience (2008-present)
  • Scientific Reports (2015-present)
  • Cells (2020-present)

 

Reviewer

  • Nature
  • Science
  • Nature Reviews Neuroscience
  • Nature Neuroscience
  • Neuron
  • Nature Communications
  • Brain
  • Proceedings of the National Academy of Sciences - USA
  • PLoS Biology
  • Nature Protocols
  • Cell Reports
  • eLife

Scientific summary

My main scientific achievements are: 1) discovery of the spike timing-dependent plasticity (STDP) rules in the hippocampus in vitro (Debanne et al., PNAS 1994; Debanne et al., PNAS 1996; Debanne et al., J Neurophysiol., 1997; Debanne et al., J Physiol. 1998; Debanne et al., J Neurosci. 1999), 2) mechanisms of short-term synaptic plasticity at unitary synapses (Debanne et al., J Physiol. 1996), 3) characterization of propagation failures along the axon (Debanne et al., Nature 1997; Kopysova & Debanne, J Neurosci. 1998), 4) Hebbian plasticity of intrinsic excitability (Daoudal et al., PNAS 2002; Campanac & Debanne, J Physiol., 2008; Campanac et al., J Neurosci. 2008; Campanac et al., Neuron 2013; Incontro et al., J Neurosci 2021), 5) mechanisms and plasticity of neuronal timing (Sourdet et al., J Neurosci. 2003; Boudkkazi et al., Neuron 2007; Cudmore et al., J Neurosci. 2010; Boudkkazi et al., J Physiol. 2011, Gastrein et al., J Physiol 2011; Campanac et al., Neuron 2013) and 6) the role of axonal ion channels in information processing (Rama et al., Nat Commun 2015, Zbili et al., Sci Adv 2020; Zbili et al., PNAS 2021).

My current reseach is focussed on 1) the mechanisms of long-lasting, intrinsic plasticity in cortical and subcortical neurons, 2) the determinents of action potential threshold, 3) the role of axonal ion channels in information processing and 4) spike-timing-dependent plasticity (STDP) rules in physiological conditions.

To address these questions, we employ 1) multiple whole-cell patch-clamp recordings in brain slices (from two connected neurons or from the axon / cell body), 2) laser scanning microscopy imaging (Ca2+, Na+, voltage), 3) computer modeling, 4) hybrid neuron-computer techniques (dynamic-clamp, hybrid networks) and 5) molecular tools (single neuron electroporation in slice cultures).

Supported by CNRS, INSERM, ANR, FRM, Ministry of Research & Région PACA.

 

Main publications as senior author (2013-present):

Zbili M, Rama S, Benitez MJ, Fronzaroli-Molinieres L, Bialowas A, Boumedine-Guignon N, Garrido JJ & Debanne D (2021) Homeostatic regulation of axonal Kv1 channels accounts for both synaptic and intrinsic modifications in the hippocampal CA3 circuit. Proceedings of the National Academy of Sciences USA. 118: e2110601118.

Incontro S, Sammari M, Azzaz F, Inglebert Y, Ankri N, Russier M, Fantini J & Debanne D (2021) Endocannabinoids tune intrinsic excitability in O-LM interneurons by direct modulation of postsynaptic Kv7 channels. Journal of Neuroscience 41: 9521-9538.

Fékété A, Ankri N, Brette R & Debanne D (2021) Neural excitability increases with axonal resistance between soma and axon intial segment. Proceedings of the National Academy of Sciences USA. 118: e2102217118.

Inglebert Y, Aljadeff J, Brunel N & Debanne D (2020) Synaptic plasticity rules with physiological calcium levels. Proceedings of the National Academy of Sciences USA. 117: 33639-33648.

Zbili M, Rama S, Yger P, Inglebert Y, Boumedine-Guignon N, Fronzaroli-Molinieres L, Brette R, Russier M & Debanne D (2020) Axonal Na+ channels detect and transmit levels of input synchrony in local brain circuits.  Science Advances 6: eaay4313.

Debanne D, Inglebert Y & Russier M (2019) Plasticity of intrinsic neuronal excitability. Current Opinion in Neurobiology 54: 73-82.

Seagar M, Russier M, Caillard O, Maulet Y, Fronzaroli-Molinieres L, De San Feliciano M, Boumedine-Guignon N, Rodriguez L, Zbili M, Usseglio F, Formisano-Tréziny C, Youssouf F, Sangiardi M, Boillot M, Baulac S, Benitez MJ, Garrido JJ, Debanne D, El Far O (2017) LGI1 tunes intrinsic excitability by setting the density of axonal Kv1 channels. Proceedings of the National Academy of Sciences USA 114: 7719-7724.

Rama S, Zbili M, Bialowas A, Fronzaroli-Molinieres L, Carlier E, Marra V & Debanne D (2015) Presynaptic hyperpolarization induces a fast analogue modulation of spike-evoked transmission mediated by axonal sodium channels. Nature Communications 6: 10163.

Campanac E, Gasselin C, Baude A, Rama S, Ankri N & Debanne D (2013) Enhanced intrinsic excitability in basket cells maintains excitatory-inhibitory balance in hippocampal circuits. Neuron 77: 712-722.

Debanne D, Bialowas A & Rama S (2013) What are the mechanisms for analogue and digital signaling in the brain? Nature Reviews Neuroscience 14: 63-69.

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