CV Science

Ewen LESCOP PhD in structural biology / NMR

Course and current status

2018 - 2019 : Part-time Visiting Scientist at Wuhan Institute of Physics and Mathematics (China)

2013 : Habilitation à Diriger des Recherches (HDR)

2007 – present : CNRS research associate at ICSN Gif-sur-Yvette – Université Paris-Saclay

2006 – 2007 : Post-doctoral Fellow at Institute of Structural Biology (Grenoble)

2004 – 2006 : Post-doctoral Fellow at Beijing NMR Center (Peking University, China)

2000 – 2003 : Ph.D.  at ICSN - University Paris-Sud

1996 – 1999 : Elève at the Ecole Polytechnique (Palaiseau)

List of research administrative functions

2012- 2016: Elected member of the CoNRS section 16

Representative of Industrial Affairs for the IR-RMN research infrastructure since 2016

Board Member of Renafobis since 2016

List of expertise functions.

Expert Evaluation Committee Marie Skłodowska-Curie Actions Individual Fellowships (IF)

Expert Evaluation of ANR projects, ANR (2), Swiss National Science Foundation

Scientific summary

Nuclear Magnetic Resonance (NMR) spectroscopy provides a wealth of information about the structure and dynamics of biomolecules in solution as well as of their complexes. As such, it highly contributes to our understanding of the molecular mechanisms that underly life. Such knowledge is fundamental not only for the general quest for a better understanding of nature but is also required for rational approaches in health or agronomy industry.

Using NMR spectropscopy as a main technique I contributed to understand the role of interdomain dynamics in the catalytic cycle of the human CPR, the role of heme orientation in the function of the hexacoordinated human neuroglobin and the structural and dynamics study of microcins and their biogenesis. More recently I started a research program about the interactome of TCTP in the context of tumor reversion and studies on the release of peptides encapsulated in liposomes. Because NMR is still an evolving technique, I also contribute to development of NMR methods, in particular to speed up NMR data collection.