Anne Galinier Metabolism and regulation of cellular processes in Bacillus subtilis

Course and current status

July 1992: PhD defense (Lyon University)

October 1994: Recruited as CR2 CNRS (at IBCP in Lyon).

March 1999: HDR (Lyon University)

December 2000: Arrival to LCB in Marseille as CR1 and Team Leader.

October 2007: DR2 CNRS and Team Leader (LCB Marseille)

Scientific production: 65 publications in Medlne; H number: 30.

Scientific summary

Cellular processes in bacteria, such as division or morphogenesis, are controlled spatially and temporally along the cell cycle. They are highly coordinated with metabolism to ensure the production of viable progeny. In my team, we study physiology of Bacillus subtilis, used as a Gram-positive rod shaped model bacterium. In particular, we are interested in understanding how bacteria can coordinate different cellular processes according to nutritional conditions. For example, through a candidate approach, we are deciphering the role of genes of unknown function linked to genes involved in metabolism. We are also studying the regulatory role of protein phosphorylation in key cellular processes. Indeed, in a wide range of bacteria, it has been shown that serine threonine kinase proteins (STKP) are involved in many bacterial processes including central metabolism, sporulation, cell shape and virulence..... In situ phosphoproteome studies have led to the publication of long lists of phosphorylated bacterial proteins on serine and threonine residues, suggesting that much remains to be discovered about the regulatory potential of these enzymes in various cellular processes. We are studying the regulatory role of protein phosphorylation in B. subtilis and how protein kinases regulate growth, division, morphogenesis etc...

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