Gerard Friedlander
  • E-mail :[email]
  • Phone : +33 1 40 61 53 10
  • Location : Paris, France
Last update 2011-06-06 11:56:39.29

Gerard Friedlander MD, PhD. Professor of Physiology

Course and current status

 Name :                                    Gérard FRIEDLANDER, M.D., Ph.D.

Date and place of birth:             June 18, 1952, Paris, France

Professional Address                      Inserm U845 Research Center “Growth and Signaling”

                                               Faculté de Médecine Paris Descartes, site Necker

                                               156, rue de Vaugirard, 75730 Paris Cedex 15, France

                                               Tel. +33 1 40 61 53 10 ; Fax +33 1 43 06 04 43  


Present position

Hospital functions     

Head, Department of Physiology & Radio-isotopes - Hôpital Européen Georges-Pompidou,

20, rue Leblanc - 75015 Paris - Tel. 01 56 09 39 69

Research functions

Director, Research Center “Growth and Signaling” Inserm U845 & Dept. of Physiology, Paris Descartes University

Teaching activities

Professor of Physiology; Paris Descartes Medical School


Postgraduate training

1969 - 1975                              M.D. Faculté Saint-Antoine, Pierre et Marie Curie University Paris, France

1980 - 1984                              Ph.D. (Physiology) - Denis Diderot (Paris 7) University, Paris, France


Professional Experience and Positions held

1977 - 1981                              Resident physician, Paris

1982 - 1989                              Assistant Professor of Physiology, Director: Pr Claude Amiel,

                                               Bichat Hospital, Paris

1989 - 2004                              Professor of Physiology, Dept of Physiology and Bichat hospital, Paris 7 University

1995 - 2005                              Director of research unit Inserm 426


Awards and Honors

2002    Eloi Collery Award of the National Academy of Medicine

2001    Chevalier dans l'ordre de la Légion d'Honneur


Scientific societies

                                               National Academy of Medicine

                                               French Speaking Society of Nephrology

                                               French Society of Physiology

                                               European Society of Nephrology

                                               American Society of Nephrology

                                               International Society of Nephrology

                                               European Dialysis and Transplant Association – European Renal Association

                                               Academia Europaea

                                               American Society of Bone and Mineral Research


Editorship and editorial boards

2007 -                                      Member of the Editorial Board, Kidney International

2002 - 2006                            Editor in chief, Medecine-Sciences

2000 -                                      Associate Editor, Nephrology, Dialysis, Transplantation


Boards and Committees

International Committees

1993 - 1997                              Councillor, European Society for Clinical Investigation

1996 - 1999                              Councillor, European Kidney Research Forum

2003 - 2007                              Councillor, European Kidney Research Association

French Committees

1994 - 1997                              Chairman, Pedagogic Council, Xavier-Bichat Faculty

1999 - 2002                              Councillor, Scientific Committee,

Fondation pour la Recherche Médicale (Medical Research Foundation)

1999 - 2002                              Chairman, INSERM Committee n°7

                                               (Nephrology, Gastroenterology, Dermatology)

2002 - 2004                              Member, Administrative council, University Paris7

2005 - 2007                              Member, Administrative council, Paris Descartes University

2008 -                                      Member, Scientific council, Paris Descartes University

2008 -                                      Vice-Dean, Paris Descartes School of Medicine

Main publications (limited to 10) 

Prié D, Friedlander G. Genetic disorders of renal phosphate transport. N Engl J Med, 2010, 362, 2399-409

Karim Z, Gérard B, Bakouh N, Alili R, Leroy C, Beck L, Silve C, Planelles G, Urena-Torres P, Grandchamp B, Friedlander G, Prié D. Human NHERF1 mutations and renal parathyroid hormone responsiveness. New Engl J Med, 2008, 359, 1128-35.

Lautrette A, Li S, Alili R, Sunnarborg SW, Burtin M, Lee DC, Friedlander G, Terzi F Angiotensin II and EGF receptor cross-talk in chronic kidney diseases: a novel therapeutic approach. Nat Med 2005, 11, 867-74.


Pillebout E, Weitzman JB, Burtin M, Martino C, Federici P, Yaniv M, Friedlander G, Terzi F. JunD protects against chronic kidney disease by regulating paracrine mitogens. J Clin Invest. 2003, 112, 843-852.

Prie D, Huart V, Bakouh N, Planelles G, Dellis O, Gerard B, Hulin P, Benque-Blanchet F, Silve C, Grandchamp B, Friedlander G. Nephrolithiasis and osteoporosis associated with hypophosphatemia caused by mutations in the type 2a sodium-phosphate cotransporter. N Engl J Med, 2002, 347, 983-991

Terzi F, Burtin M, Hekmati M, Federici P, Grimber G, Briand P, Friedlander G. Targeted expression of a dominant-negative EGF-R in the kidney reduces tubulo-interstitial lesions after renal injury. J Clin Invest, 2000, 106, 225-234

Essig M, Nguyen G, Prié D, Escoubet B, Sraer JD, Friedlander G. 3-Hydroxy-3-Methylglutaryl Coenzyme A reductase inhibitors increase fibrinolytic activity in rat aortic endothelial cells. Circ Res, 1998, 83, 683-690

Terzi F, Henrion D, Colucci-Guyon E, Federici P, Babinet C, Levy BI, Briand P, Friedlander G. Reduction of renal mass is lethal in mice lacking vimentin. Role of endothelin-nitric oxide imbalance. J Clin Invest, 1997, 100, 1520-1528.

Fernandes I, Hampson G, Cahours X, Morin P, Coureau C, Couette S, Prié D, Biber J, Murer H, Friedlander G, Silve C. Abnormal sulfate metabolism in vitamin D-deficient rats. J Clin Invest, 1997, 100, 2196-2203.

Friedlander G, Couette S, Coureau C, Amiel C. Mechanisms whereby extracellular adenosine 3',5'-monophosphate inhibits phosphate transport in cultured opossum kidney cells and in rat kidney. Physiological implication. J Clin Invest, 1992, 90, 848-858.

Scientific summary

Phosphate (Pi) homeostasis has a central place in metabolism, cellular proliferation, development, and bone mineralization. Pi homeostasis relies on a coordinate function of membrane transporters (ubiquitous PiT, epithelial NPT), of intracellular regulatory proteins and of endocrine and paracrine modulators. 

Our purpose is to study Pi homeostasis at the level of the cell and of the whole organism, both in normal and pathological situations.

Cellular Pi homeostasis

Cellular and molecular Pi physiology

. We propose (a) to investigate the specificity of PiT1 and PiT2 expression in response to transcription factors and growth factors through promoter studies; (b) to get insights into the mechanisms underlying the role of PiT1 in cell proliferation and modulation of the cell cycle; (c) to evaluate the role of PiT1 and PiT2 as Pi sensors.

Consequences of PiT1 invalidation.

We shall evaluate, in vivo, the phenotypic consequences of PiT knockout (allelic series obtained by homologous recombination) or conditional invalidation (cre-lox) in the mouse: (a) during development, focusing on bone, liver and kidney; (b) in pathological situations (renal acute and chronic injury, liver regeneration and hepatocarcinoma.

Phosphate homeostasis at the organism level

This clinical research aims to : (a) dissect at the molecular level renal Pi leaks which lead to renal stones and bone loss: identification and characterization (heterologous expression) of mutations affecting renal transporters NPT2a, NPT2c, and regulatory proteins NHERF1 and NHERF2; (b) look for structure/secretion abnormalities of phosphaturic peptides such as FGF23; evaluate the implication of klotho, a recently identified gene involved in cardiovascular aging, in end stage renal failure-associated hyperphosphatemia and in vitamin D metabolism.

This project, which combines experimental and clinical research, takes place in the context of the renewal of the “Growth and Signaling” Inserm Research Center U845 on the Necker campus. It involves 1 full-time scientist (CR1), 4 hospital/university investigators, 3 engineers and technicians, 2 post-docs and 3 PhD students.

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