Sébastien Bontemps-Gallo PhD Microbiology

Course and current status

Current position

  • Research Associate in the Center for Infection and Immunity of Lille at the Institut Pasteur de Lille



  • 2021: HDR (University of Lille)
  • 2013: PhD in Microbiology (University of Lille - CNRS UMR8576)



  • Since 2019: CRCN CNRS (Research Associate)
  • 2018-2019: Research associate at the Institut Pasteur of Lille
  • 2014-2018: Post-doctoral fellow at RML, NIAID, NIH USA - Director: Dr F. Gherardini
  • 2013-2014: Assistant Professor (ATER) at University of Lille - Director: Pr JM Lacroix

Recent grants

  • 2022-2026: ANR JCJC Role of a cell signalling system in the adaptation of Yersinia pestis to its vector – RESISTANT (ANR-21-CE15-0047)
  • 2020-2022: I-Site ULNE Young Researcher 2020 Adaptation of Yersinia pestis to its vector - APPETISER (ANR-16-IDEX-0004 ULNE)

Scientific summary

My research focuses on how bacteria adapt to their environment to establish an infection. I work on different pathogens of animal (Borrelia burgdorferi s.l. - Lyme disease, Yersinia pestis - Plague) or plant (Dickeya dadantii - soft rot disease).

Dr. Sébastien Bontemps-Gallo received his doctorate in 2013 from the University of Lille (France). During this three-year PhD thesis in Pr Jean-Marie Lacroix' lab, he investigated the role of osmoregulated periplasmic glucans in the physiology and the virulence of D. dadantii. He also investigated the mechanism by which D. dadantii senses and adapts to osmotic stress. Then, during a one-year assistant professor position in the same lab, he studied the role of the envelope stress two-component system CpxAR in the virulence.From there, Sébastien pursued his research career with a four-year postdoctoral fellowship at the National Institutes of Health (NIH - Rocky Mountain labs) in Dr. Frank Gherardini's lab. His research work dealt with osmoadaptation of Borrelia burgdorferi s.l. during its life cycle, with an emphasis on the tick part of the cycle. He studied the effect of protein acetylation on the metabolism of B. burgdorferi. Currently, Sébastien is a Research Scientist (CRCN CNRS) at the Institut Pasteur of Lille - Center for Infection & Immunity of Lille in Dr. Florent Sebbane's lab (INSERM/CNRS). His research focused on adaptation to stress in the flea of Yersinia pestis.

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