CV Science

Arnauld Sergé PhD HDR, Associate Professor in Biophysics , Aix-Marseille University

Course and current status

• Present position: Associate Professor, LAI, Aix-Marseille University, France 

Dynamic videonanoscopy of immune-cancer interactions

• 2013-2019     Associate Professor, CRCM, Aix-Marseille University, France 

Team Junctional adhesion molecules in tumor/host interactions, M Aurrand-Lions

Dynamic study of the molecular processes of the plasma membrane 

• 2011-2012     Sabbatical, Department of Pathology & Immunology, Geneva Medical Faculty, Switzerland

Team Vascular and leukocyte adhesion molecules and cell migration, Pr BA Imhof

In vivo study of the interactions between lymphocytes and their environment

• 2003-2010    Assistant Professor, CIML, Aix-Marseille University, France

Team Membrane dynamics and T lymphocyte signaling, HT He & D Marguet

Membrane dynamics of the EGFR – multiple target tracing

• 2001-2003     Postdoctoral training, Physics department, Leiden University, the Netherlands

Team Physics of life processes, Pr T Schmidt

Dynamic reorganisation of the plasma membrane on single molecule stimulation, in vivo

• 1997-2001     PhD in neurobiology, Bordeaux University, France

Team Cellular physiology of the synapse, supervisor: D Choquet

Membrane mobility of glutamate receptors

• 1996 National service: cooperation, professor of Physics, Fada N’Gourma, Burkina Faso

https://www.researchgate.net/profile/Arnauld_Serge

https://www.linkedin.com/in/arnauld-sergé-82a14761/

https://scholar.google.fr/citations?user=2hP3KjIAAAAJ&hl=fr

http://orcid.org/0000-0003-4271-3706

Scientific summary

Dynamic videonanoscopy of immunocancer interactions

Cell junctions play a key role in the integrity of biological tissues through interactions between cell surface proteins. These interactions are profoundly altered during the development of cancerous cells as well as during the passage of leukocytes through the walls of blood vessels, in infectious or tumour contexts. Advances in optical microscopy make it possible to detect a single fluorescent molecule with nanometric precision. This approach provides a resolution comparable to electron microscopy, while being compatible with the observation of living cells.

My goal is to document the dynamics of adhesion molecules by videonanoscopy. The analysis of molecular trajectories using dedicated personal algorithms will allow the identification of interaction, stabilization and intracellular trafficking events. The establishment and dynamic evolution of junctions will be studied in different cellular, immune and cancerous contexts.