Marie-Lise Bats PharmD PhD Biology and Biochemistry

Course and current status

2001-2006 PharmD Student-University of Bordeaux 2

2006-2012 Medical Biology Internship- University Hospitals of Limoges, Bordeaux and Toulouse 

2011 PharmD- University of Limoges

2014 PhD- Physiopathology in Biology-Health-Biotechnology – University of Toulouse 3

From 2014, teacher in the Department of Biochemistry and molecular biology of Bordeaux university, researcher in the Inserm 1034 unit "biology of cardiovascular diseases" and medial biologit in the Department of biochemistry of university hospital of Bordeaux. 

Scientific summary

Wnt signaling was reported to modulate blood-retina and blood-brain barrier (BRB and BBB) integrity and to be required to induce maturation of the BBB tight junction properties in vitro and in vivo. Consistently, we and others have reported that canonical versus non canonical Wnt/Frizzled signaling may influence endothelial cell behavior by promoting cell proliferation versus cell migration, and cell/cell 3D organization. We have then addressed open questions about a functional role of the Wnt canonical signaling as a regulator in retinal post-natal angiogenesis and pathological retinal vascular pathology, about the contribution of Wnt non canonical signaling in the polarized vascular cell organization and in the maintenance of vessel integrity in pathological vascular cerebral disease outcome and extended this concept to cardiac function and failure.

I evaluate the impact of Fzd7 receptor and others Wnt signaling partners in physiological angiogenesis (e.g. response to laminar and distubed flow), and pathological angiogenesis such as retinopathy, heart failure and vascular cognitive impairment. 

Technical approaches : - Transgenic mice - Model of oxygen-induced retinopathy - Molecular analysis by QPCR - Intravitreal microinjection of pharmacological drugs- Cell culture- Proteomic anaysis- Model of rotative flux.  

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