CV Science

Pierre-Louis THARAUX Research Professor, Nephrology and Vascular Diseases - M.D., PhD.

Course and current status

Education and Training :

Medical studies at Faculté Necker-Enfants Malades- Université Paris Descartes.

Interne des Hôpitaux de Paris (1991)

Fellowship in Nephrology (1991-1998). Nephrology: Board Certified (1998).

Medical Doctorate from Université Paris Descartes (1998). Suma cum laude

PhD. in Physiology & Pathophysiology from Université Pierre & Marie Curie (2000). Suma cum laude.

2000- Curriculum in physiology and pathophysiology of sleep and cardiovascular disorders, Université Paris Sud.

Professional Experiences and awards:

1990-1996 : “Internat de Médecine” (Residency and Fellowship equivalent) in Paris : (ICU, nephrology, hepatology, endocrinology, physiology).

1997-2000 : Research: Internat of Paris Fellowship, Silver medal award of Assistance Publique-Hôpitaux de Paris, INSERM fellowship for biomedical research.

2000-2002 : Research Associate, Duke University Medical Center, Durham, NC,  Dr Thomas M Coffman laboratory and Curriculum in Genetics, University of North Carolina, Dr Beverly Koller lab. Fellow of the Simone and Cino del Duca Fundation and Elli-Lilly International fellow.

2002- present: INSERM Investigator and contractor with Assistance Publique-Hopitaux de Paris (AP-HP). Goal: To conduct translational research from preclinical to clinical fields in vascular and renal pathophysiology.

2009- present: Inserm Research Professor and Team leader, Paris Cardiovascular research Center / PARCC @ HEGP, Inserm.

2020- present: Guest Professor, the Hamburg Centre for Kidney Health, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. https://hckh.org/teams/guest-professors/pierre-louis-tharaux

2022 - present: Deputy director of the Inserm PMN Institute for Physiopathology, Metabollism, Nutrition.

Honors-Awards

- Année-Recherche de l’Internat (Research fellowship for excellence in Medicine) – 1995

- Silver medal for Interns in Paris Public University Hospitals, AP-HP, 1997

- INSERM fellowship for biomedical research (poste d'accueil) – 1998

- Louis Auquier / AP-HP award for Academic Achievement in Medicine - 1999

- European Society of Microcirculation Young Investigator award- 1999

- Fondation Simone et Cino del Duca fellowship for research – 2000-2001

- Elli-Lilly International Research Fellow – 2000

- European Research Council (ERC) Consolidator Grant - 2012   

- Eloi-Collery Prize, the National Academy of Medicine - 2013

 - FRIAS Senior Fellow, Freiburg Institute for Advanced Studies (FRIAS), University of Freiburg, Germany -2015

 - European Research Council (ERC)proof of concept grant - 2018

- French Kidney Foundation / Fondation du Rein - Prize - 2019

- Inserm Research Prize - 2021

Involvement for the community:

Pierre-Louis Tharaux was a member of the INSERM Scientific Council (2003-2007), an elected member of the INSERM Scientific Committee on Physiology and Pathophysiology (CSS3)(2016-2021). He was a councilor of the French Society of Cardiology/GRRC (2013-2018), of the French Society of Hypertension (2017-2022), the French Federation of Cardiology (FFC) (2017-present) and the French Society for Rares Diseases (2023-present).

He is the president of the scientific council of the French Kidney Foundation (2022- present) and chairs the International Society of Glomerular Disease, Basic & Translational Research Committee (2023- present).

He acted as a member of the Scientific Program Committee for several international scientific meetings.

https://www.linkedin.com/profile/preview?vpa=pub&locale=fr_FR

Scientific summary

Scientific interests: Pathophysiology of the renal and extra-renal microcirculation.

Research in our laboratory “Kidney and vascular signalling: from development to disease” at the PARis Cardiovascular Center -PARCC, Paris, is centered on the analysis of vascular and renal pathophysiology, with a particular emphasis on intercellular communications and signaling pathways.

We are also active in drug target validation, drug repositioning and new drug development, targeting kidney diseases and sickle cell disease vasculopathy.

Our work covers three areas, using animal models of human diseases and clinical cohorts.

1-  Inter- and intra-cellular signaling from cell surface to genomic and epigenomic regulation in epithelial and endothelial cells in response to immune vasculitides with Crescentic Glomerulonephritis (CGN), Diabetic Nephropathy, Focal Segmental Glomerulosclerosis (FSGS), and tubulo-insterstitial fibrosis.

Promotion of kidney tolerance to immune injury (vasculitides) and metabolic injury (diabetes).

2-   Control of proteostasis and metabolism in podocytes and endothelial cells.

3-   Innate immunity in Sickle Cell Disease and Crescentic GN.

https://scholar.google.fr/citations?user=i23GHJAAAAAJ&hl=fr

https://orcid.org/0000-0002-6062-5905