After a long experience acquired in several countries, Marco Canepari (MC) has been leading several project as Principal Investigator, initially in Switzerland and later on in France where he has established his own laboratory. MC is recognized leader in the technique of Membrane Potential imaging, in particular in coupling this method with ion imaging. His expertise includes the development of novel cutting-edge instrumentation and analysis methods based on computational neuroscience. Since the beginning of his career, he devoted a large fraction of his research activity to methodological developments of imaging techniques as well as techniques of optical stimulation in particular using caged compounds. In addition to the contributions in methodological research, he performed several research projects in fundamental neurophysiology investigating several aspects of neuronal functions in different systems, including the hippocampus, the cerebellum and the thalamus. MC has also a very long record of participation as lecturer at international schools.