CV Science

Simon Lecomte PhD in Neuroscience

Course and current status

From 2021 to 2025 
PhD in the team of Christophe Mulle, IINS (Institut Interdisciplinaire de Neurosciences), CNRS UMR 5297, University of Bordeaux, France (obtained with distinction).

This project investigated how loss of FMRP affects presynaptic mechanisms in the CA3 region of the hippocampus, with a specific emphasis on cAMP-PKA signaling. Using patch-clamp electrophysiology and imaging in acute and fixed mouse hippocampal slices with targeted genetic mutations in dentate gyrus cells, I showed that presynaptic loss of FMRP disrupts mossy fiber-CA3 synaptic transmission. My results indicated a deregulation of cAMP-PKA signaling and altered presynaptic calcium-dependent mechanisms, providing new insights into the presynaptic contribution of FMRP to synaptic function in Fragile X Syndrome.
Methods : patch-clamp, 2P imaging, immunohistochemistry, electron microscopy.

From 2019 to 2021
M.Sc. (International) of Neuroscience at the University of Bordeaux, France (obtained with distinction).

• 2021 : Internship of five months at the Neurocentre Magendie (Bordeaux, France) in the team of Stéphane Oliet "Glia-neuron interactions", supervised by Stéphane Oliet. The aim of the project was to discover the cellular mechanisms of the active and basal release of astrocytic D-serine in the hippocampus. Slice electrophysiology.
• 2020 : Internship of two months at the Neurocentre Magendie (Bordeaux, France) in the team of Stéphane Oliet "Glia-neuron interactions", supervised by Aude Panatier. The aim of the project was to find out whether the activation of the astrocytic receptor EphrinB3 leads to the exocytosis of D-serine by astrocytes and thus to the induction of hippocampic LTP. Slice electrophysiology.

From 2016 to 2019
B.Sc. of Psychology at the University of Strasbourg, France (obtained with distinction).

• 2019 : Internship of thirty hours at the INCI (Institut de Neurosciences Cellulaires et Intégratives, Strasbourg, France) in the team of Etienne Challet "Neurobiology of rythms", supervised by Etienne Challet. Immunohistochemistry.
• 2018 : Internship of two months at the INCI (Institut de Neurosciences Cellulaires et Intégratives, Strasbourg, France) in the team of Michel Barrot and Ipek Yalcin "Pain and nociception", supervised by Pierre-Eric Lutz. Conditionned place preference, immunohistochemistry.

2016
Scientific baccalaureate at the Lycée français 'Victor Hugo' of Frankfurt, Germany (obtained with distinction).

Scientific summary

Neurovascular coupling and brain circuits

My scientific interests lie at the intersection of neural circuits, glial biology, and neurovascular coupling. I am particularly interested in how neurons, astrocytes, and the cerebral vasculature interact to shape brain function across scales, from synaptic mechanisms to network dynamics. The study of these cellular and vascular interactions is emerging as a major field in neuroscience, offering new insights into information processing, metabolic support, and brain plasticity. This rapidly evolving area holds strong promise for advancing our understanding of both normal brain physiology and the mechanisms underlying neurological and psychiatric disorders.