Victorine Douin Effect of aging on cardiac stromal cell biology

Course and current status

Assistant professor in Physiology (faculty of Pharmaceutical Sciences, Paul Sabatier University) and in the team Cardiac remodelling : pathophysiology and new therapies (Pr A Parini), Institute of Metabolic and Cardiovascular Diseases I2MC, Inserm U1048, Toulouse, France

Degrees : PhD of Biology-Health-Biotechnology (2001) and Pharmaceutics thesis (1997) Paul Sabatier University, Toulouse, France

2010 Post-doctoral position in the departement of Metabolism and Obesity (Pr R Burcelin), I2MR, Inserm U858, Toulouse, France.

2009-2004 Assistant professor in the departement of Physiology (Pr JF Arnal) at the Medecine faculty, Paul Sabatier University and Inserm U858, Toulouse, France. 

2003-2004 Post-doctoral position in the departement of Molecular Immunology and T cell Biology (Dr JC Guéry), CPTP, Inserm U563, Toulouse, France.

2002-2003 Assistant professor in the departement of Biochemistry and Molecular Biology (Pr G. Favre and Pr F LeGaillard) at the Pharmaceutics faculty, Paul Sabatier University, Toulouse, France.

Scientific summary

Homeostasis of adult tissues results of a crosstalk between the parenchyma and the stromal components including extracellular matrix and interstitial heterogeneous cellular actors. Mesenchymal stromal cells have been identified in solid tissues of rodents and humans including heart, kidney, lung, liver and adipose tissue. These cell populations are heterogeneous, dynamic, and regulate surrounding cells by their paracrine activities and participate in cell tissue renewal. Aging is generally associated to a progressive decline of organ functions that predispose to chronic diseases. At present, the contribution of mesenchymal stromal cell senescence and dysfunction in aging-associated organ failure is unknown.

Our project aims to characterize the evolution of mesenchymal stromal cell subpopulations and their functions during aging in the heart as well as their interplay with cardiac macrophages, crucial stromal actors of the innate immune response. 

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