Coralie Sengenès PhD Pharmacology

Course and current status

-Since January 2012, Research Scientist : INSERM U1031 (Louis Casteilla), Team 1, Toulouse. Research program : Homing and mobilization activities of endogenous adipose stromal cells.  

-2006-2011, Research Scientist : INSERM U1048 (Angelo Parini), Team 1 (Anne Bouloumié), Toulouse.Research program : Human adipose stromal cells : analysis of homing and mobilization activities. 

-2002-2006 : Post Doc : Institute for Cardiovascular Physiology, R. Busse, Frankfurt am Main, Germany.Research program: Human adipose stromal cells : Roles and Phenotypes.

-1998-2002: PhD student : INSERM U317 (Max Lafontan), Toulouse, France. Research program: Natriuretic peptides: intracellular mechanisms and physipathological roles of a new lipolytic pathway in human adipose tissue.

Scientific summary

By investigating motility and migration of adipose tissue (AT) stem/progenitor cells we are studying novel aspects of AT biology since this area of research is largely uncovered so far. We hypothesize that AT stem/progenitor cells are motile in vivo thus being able to invade other tissues in physiological or pathophysiological conditions. This research program might identify AT stem/progenitor motility as a potential target for AT physiology and physiopathology. Excessive AT development (referred to as obesity) is associated with ectopic fat deposition; known to induce metabolic disorders rather then obesity per se. Controlling the mobility of AT stem/progenitors might be a very exciting and unexplored approach to understand deleterious ectopic fat deposition.This research program is directly relevant in term of public health since obesity is a leading preventable cause of death worldwide with increasing prevalence. Finally, identifying molecular and cellular factors controlling AT stem/progenitor cell motility might also bring targets to ameliorate their use in regenerative medicine (optimisation of homing in damaged tissues). 

Image d’exemple