CV Science

Thierry Huby INSERM Research Scientist

Course and current status

Since 2025 : Tenured Researcher (CRHC INSERM, HDR) at Sorbonne Université, INSERM, UMRS_1269 Nutrition and obesities: systemic approaches, NutriOmics, Paris, France (Director: Prof. Karine Clément)

2014-2024: Researcher at INSERM UMRS-1166; 2009-2013: Researcher at INSERM UMRS-939 ; 2000-2008: Researcher at INSERM UMRS-551

1997-1999: Post-doc at Lawrence Berkeley National Laboratory, Science genome Dept, University of California (Supervisor: Dr Edward Rubin), Berkeley, California.

1997: PhD in Biochemistry. University of Paris Diderot, France.

Scientific summary

I am an INSERM researcher with a background in basic research on lipoprotein metabolism and atherosclerosis. I obtained a PhD in biochemistry from Paris Diderot University. I then completed a postdoctoral fellowship at the Lawrence Berkeley National Laboratory in California under the supervision of Dr. Edward Rubin. During this time, I developed skills in molecular biology and created various mouse models to study gene regulation and function. Part of my research focused on evaluating the tissue-specific role of the scavenger receptor Srb1. I examined its impact on systemic and cellular cholesterol metabolism, and the subsequent effects on lipoprotein metabolism, glucocorticoid responses, and atherogenesis. In recent years, I have shifted my focus to exploring the role of macrophages, and in particular hepatic macrophages, in the development of cardiometabolic disorders (MASH, atherosclerosis). My research integrates the use and development of novel mouse models, in vivo preclinical explorations, and omics approaches, such as RNA-sequencing and lipidomics, to decipher macrophage functions under both physiological and pathological conditions.