CV Science

Stéphane Mouly MD PhD Therapeutics & Internal Medicine

Course and current status

Ô Full Professor of Internal Medicine, Lariboisière hospital, Paris (Since September 2008)

Ô Associate Professor in Internal Medicine, Lariboisière hospital, Paris (Since May 2005)

Ô Assistant Professor in Internal Medicine, Lariboisière hospital, Paris (2001-2005)

Ô Paris University Hospital’s Residency in Internal Medicine and Infectious Disease Program (Numerus Clausus with 10% passing rate (1994-1999)

Ô Graduated Magne cum Laude (October 1999)

Ô Medical school, XAVIER-BICHAT hospital, University of Paris VII (1988-1993)

Ô School leaving certificate, scientific section (1987)

Scientific summary

Ô Hepatic drug metabolism evaluation using the Caffeine test and the ¹⁴C Erythromycin Breath Test (ERMBT)

Ô Pioneer in the use of the ERMBT in Europe in 2000 

Ô Ganciclovir assay, saquinavir assay, and Caffeine metabolites assays, using sensitive and reproducible HPLC methods

Ô Quantitative and qualitative protein measurement using immunoblotting techniques

Ô Nucleic acid extraction from human tissue samples

Ô P-glycoprotein measurement in peripheral lymphocytes using flow cytometry

Ô Clinical trials performance

Intestinal absorption and hepatic metabolism in HIV-infected patients with and without diarrhea

Use of the ¹⁴C-Erythromycin Breath Test to individualize the dosing regimen in HIV-infected patients starting a new HAART

Ô Evaluation of intestinal absorption and permeability in HIV-infected patients with and without diarrhea and weight loss

Ô Use of the Caco-2 cell culture system engineered to co-express intestinal P-glycoprotein and cytochrome P450 (CYP)3A4/5

Ô Use of various pharmacogenetic tools in clinical trials determined by RT-PCR, including MDR1, CYP3A4, CYP3A5, CYP2C9 and CYP2D6 genetic polymorphisms

Ô Modeling

Pharmacokinetic analyses (by compartmental and noncompartmental methods) using Winnonlin or equivalent

Population pharmacokinetics (by compartmental and noncompartmental methods) using MICROPHARM MP2 and NONMEM

Ô Other softwares

Data analysis and presentation (EXCEL-POWERPOINT)

Statistical analysis (STATVIEW)

Ô Communication

Interaction with clinical and pharmacological research staffs to implement and complete pharmacokinetic and clinical studies

Creation of a scientific interactive database available at

http://bigfoot.med.unc.edu/watkinsLab