- E-mail :[email]
- Phone : +33 5 19 56 42 50 (research unit) or +33 5 55 05 61 40 (hopsital)
- Location : Limoges, France
Scientific topics
Keywords
ITMO
Last update 2016-10-17 17:35:39.042
Nicolas Picard PharmD, PhD (Pharmacology and Pharmacogenetics)
Course and current status
- Full professor - hospital pharmacologist (PU-PH; Since 2015)
Faculty of Pharmacy and University Hospital, Limoges, France - Head of the teaching dpt of Pharmacology
Faculty of Pharmacy, Limoges (since 2014) - Associate professor in Pharmacology
& Hospital doctor in Pharmacogenetics (MCU-PH) (2006-2015)
Faculty of Medicine-Pharmacy and University Hospital, Limoges, France
- French accreditation to supervise research
"Habilitation à diriger des Recherches, HDR" (2010)
University of Limoges, France
- Postdoctoral periods
April-Sept 2008 : Center for Pharmacogenomics, UCSF, San Francisco, CA (Prof. KM Giacomini)
June-Sept 2012 & May-August 2014 : Dpt of Pharmacokinetics and toxicology, Timone Hospital, Marseille, France (Prof. B Lacarelle)
- PhD in Pharmacology (2005)
University of Limoges - Master degree (DEA) in clinical and experimental Pharmacology (2002)
University Paris XI, France - Doctorate of Pharmacy (2002)
Faculty of Pharmacy, Limoges, France
Scientific summary
Research unit : INSERM UMR-850 « Pharmacology of immunosuppressants in transplantation » The unit was created in 2007 and is jointly supported by INSERM and the University of Limoges with a strong partnership with the University Hospital of Limoges, France.
Main research interests
- Pharmacogenetics of immunosuppressants and other treatments in transplantation.
- Drugs and xenobiotics disposition in humans
- Pharmacoepigenetics
- Next-Generation Sequencing
Clinical routine activity
- Head of the pharmacogenetics unit at Limoges University hospital (UF8921 of molecular genetics) : testing include: DPYD/fluoropyrimidines, TPMT/thiopurines, CYP3A5 and CYP3A4*22/tacrolimus, UGT1A1/irinotecan, VKORC1-CYP2C9/anticoagulants, IL28B/hepatitic C therapy, CYP2C19/voriconazole
- Registered at the 'G' section (Biologist) of the Pharmacist national council and authorized by the National Biomedicine Agency
Experience and Skills
- Pharmacogenetics: Experience includes real time PCR (TaqMan technology, ABI Prism), High Resolution Melting and direct sequencing. IT skills include the design of assay, sequence analysis (Sequencher; genecode) and haplotype analysis. Clinical association studies and experimental pharmacogenetics.
- Drug metabolism and transport studies: Experience includes preparation and use of in vitro models (microsomes, recombinant enzymes), design of methods and strategies for identification of metabolites, enzyme, or isoforms involved in a metabolic pathway (either of phase I or phase II), enzyme kinetics, in vitro-in vivo extrapolation and drug-drug interaction studies. Transport studies using caco2, HepaRG. Molecular cloning and cell transfection.
- Mass spectrometry applied to structural elucidation and determination of small molecules.
Professional associations
- 2015-present GEPK (group of teachers in Pharmacokinetics)
- 2012-present : AEPFP (French Association of Pharmacology teachers in Faculty of Pharmacy)
- 2009-present French Association of Practitioners in Molecular Biology: « Association Nationale des Praticiens de Biologie Moléculaire » (ANPGM)
- 2003-present French Society of Pharmacology and Therapeutics (SFPT)
- 2003-present International Association of Therapeutic Drug Monitoring and clinical Toxicology (IATDMCT)
- 2003-2005 American Society for Pharmacology and Experimental Therapeutics (ASPET)
Other responsabilities
- Editorial board of the 'Therapeutic Drug Monitoring' Journal (since 2016)
- Editorial board of the 'Therapie' Journal (since 2014)
- 2012-present Member of the pharmacogenetics comitee of the international association of therapeutic drug monitoring and clinical toxicology (IATDMCT)
- 2005-present Member of the French National Network of pharmacogenetics (RNPGx) (since 2005)
- 2010-present Organiser of interregional training workshops in pharmacogenetics with the support of the GIRCI (Interregional Group of Clinical Research and Innovation) South-West and overseas France
- 2012-present Member of the scientific council of the Cancer Research Committee in Limousin (CORC, University and Hospital of Limoges)
Publications: More than 50 articles since 2004
