• E-mail :[email]
  • Phone : +33 5 19 56 42 50 (research unit) or +33 5 55 05 61 40 (hopsital)
  • Location : Limoges, France
Last update 2016-10-17 17:35:39.042

Nicolas Picard PharmD, PhD (Pharmacology and Pharmacogenetics)

Course and current status

  • Full professor - hospital pharmacologist (PU-PH; Since 2015)
    Faculty of Pharmacy and University Hospital, Limoges, France
  • Head of the teaching dpt of Pharmacology
    Faculty of Pharmacy, Limoges (since 2014)
  • Associate professor in Pharmacology
    & Hospital doctor in Pharmacogenetics (MCU-PH) (2006-2015)
    Faculty of Medicine-Pharmacy and University Hospital, Limoges, France
  • French accreditation to supervise research
    "Habilitation à diriger des Recherches, HDR"
    University of Limoges, France
  • Postdoctoral periods
    April-Sept 2008 : Center for Pharmacogenomics, UCSF, San Francisco, CA (Prof. KM Giacomini)
    June-Sept 2012 & May-August 2014 : Dpt of Pharmacokinetics and toxicology, Timone Hospital, Marseille, France (Prof. B Lacarelle)
  • PhD in Pharmacology (2005)
    University of Limoges
  • Master degree (DEA) in clinical and experimental Pharmacology (2002)
    University Paris XI, France
  • Doctorate of Pharmacy (2002)
    Faculty of Pharmacy, Limoges, France

Scientific summary

Research unit : INSERM UMR-850 « Pharmacology of immunosuppressants in transplantation » The unit was created in 2007 and is jointly supported by INSERM and the University of Limoges with a strong partnership with the University Hospital of Limoges, France.

Main research interests
  • Pharmacogenetics of immunosuppressants and other treatments in transplantation.
  • Drugs and xenobiotics disposition in humans
  • Pharmacoepigenetics
  • Next-Generation Sequencing
Clinical routine activity
  • Head of the pharmacogenetics unit at Limoges University hospital (UF8921 of molecular genetics) : testing include: DPYD/fluoropyrimidines, TPMT/thiopurines, CYP3A5 and CYP3A4*22/tacrolimus, UGT1A1/irinotecan, VKORC1-CYP2C9/anticoagulants, IL28B/hepatitic C therapy, CYP2C19/voriconazole
  • Registered at the 'G' section (Biologist) of the Pharmacist national council and authorized by the National Biomedicine Agency
Experience and Skills
  • Pharmacogenetics: Experience includes real time PCR (TaqMan technology, ABI Prism), High Resolution Melting and direct sequencing. IT skills include the design of assay, sequence analysis (Sequencher; genecode) and haplotype analysis. Clinical association studies and experimental pharmacogenetics.
  • Drug metabolism and transport studies: Experience includes preparation and use of in vitro models (microsomes, recombinant enzymes), design of methods and strategies for identification of metabolites, enzyme, or isoforms involved in a metabolic pathway (either of phase I or phase II), enzyme kinetics, in vitro-in vivo extrapolation and drug-drug interaction studies. Transport studies using caco2, HepaRG. Molecular cloning and cell transfection.
  • Mass spectrometry applied to structural elucidation and determination of small molecules.

Professional associations

  • 2015-present GEPK (group of teachers in Pharmacokinetics)
  • 2012-present : AEPFP (French Association of Pharmacology teachers in Faculty of Pharmacy)
  • 2009-present French Association of Practitioners in Molecular Biology: « Association Nationale des Praticiens de Biologie Moléculaire » (ANPGM)
  • 2003-present French Society of Pharmacology and Therapeutics (SFPT)
  • 2003-present International Association of Therapeutic Drug Monitoring and clinical Toxicology (IATDMCT)
  • 2003-2005 American Society for Pharmacology and Experimental Therapeutics (ASPET)

Other responsabilities

  • Editorial board of the 'Therapeutic Drug Monitoring' Journal (since 2016)
  • Editorial board of the 'Therapie' Journal (since 2014)
  • 2012-present Member of the pharmacogenetics comitee of the international association of therapeutic drug monitoring and clinical toxicology (IATDMCT)
  • 2005-present Member of the French National Network of pharmacogenetics (RNPGx) (since 2005)
  • 2010-present Organiser of interregional training workshops in pharmacogenetics with the support of the GIRCI (Interregional Group of Clinical Research and Innovation) South-West and overseas France
  • 2012-present Member of the scientific council of the Cancer Research Committee in Limousin (CORC, University and Hospital of Limoges)

Publications: More than 50 articles since 2004


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