CV Science

Capucine Trollet PhD, Gene and Cell Therapy, muscular dystrophy

Course and current status

2019-present : Research Director DR2 INSERM - leader of the team OPeRA: Cellular and molecular orchestration in muscle regeneration, during ageing and in pathologies (OPMD, Regeneration and Aging) together with Vincent Mouly

2010-2019 : Research Associate CR1 INSERM - in the group « Regeneration, Pathophysiology & Therapeutic Approaches: Cellular models » in the Myology Research Center in Paris directed by Gillian Butler-Browne, Paris, France. Oculopharyngeal muscular dystrophy: physiopathological mechanisms and therapeutic strategies

2005-2009 : Post-doctoral training in the School of biological Sciences directed by Pr. George Dickson, Royal Holloway, university of London, United Kingdom. Developpement of gene therapy strategies for muscular dystrophies

2002-2005 : PhD in the Chemical and genetic pharmacology laboratory directed by Daniel Scherman, University of Paris Descartes, Paris, France. Study, regulation and application of in vivo gene transfer by electrotransfer.

Scientific summary

The team focuses on molecular and cellular actors involved in human in skeletal muscle regeneration, during ageing and in muscle dystrophies, particularly oculopahryngeal muscular dystrophy (OPMD) and Duchenne muscular dystrophy (DMD). Our approaches aim at better understanding RNA metabolism, muscle regeneration, muscle stem cells and fibrosis in order to develop therapeutic strategies.

Research projects currently developed in parallel and in synergy within the team:

- molecular mechanisms involved in OPMD and in muscle ageing

- cell to cell communication during muscle regeneration, muscle aging and fibrosis

- development of therapeutic strategies