Vincent GOFFIN
  • E-mail :[email]
  • Phone : +33 1 40 61 53 23
  • Location : PARIS, France
Last update 2024-05-28 14:02:08.357

Vincent GOFFIN PhD Molecular Endocrinology

Course and current status

1986-1994: University of Liege, Belgium.  

  • 1987: M. Sc., Animal Physiology Lab
  • 1993: PhD thesis, Research assistant of the Belgian National Funds for Scientific Research (FNRS), Molecular Biology and Genetic Engineering Lab.


1994-present: Inserm and Université Paris Cité, Faculty of Medicine, Necker site, Paris, France

  • 1994-1996: Post-doctoral fellow of the European Community – Marie Curie fellowship, Molecular Endocrinology Lab
  • 1996-2005: Associate Professor, Team leader at Molecular Endocrinology Lab
  • 2006-present: Professor/Research Director, Head of "PRL/GH Pathophysiology" Lab, Institut Necker Enfants Malades (Inserm Unit 1151)
  • Since 2022 : Head of Service Unit 24 / SFR Necker (technological core facilities of Necker site)

Scientific summary

Major interests

  • Prostate cancer, benign prostate hyperplasia, and stem/progenitor cells (cell plasticity and therapeutic targeting)
  • PRL and GH in human pathophysiology 


Major findings

  • Discovery of castration-resistant luminal progenitor cells in the mouse prostate and their role in prostate tumorigenesis.
  • Development of pure prolactin receptor antagonists, used worldwide in academia since 20 years.
  • Identification of the first GOF natural variant of the prolactin receptor in benign breast diseases


Research tools

Translational approaches (preclinical cell/mouse models, organoids, human biocollections)

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