CV Science

Vincent GOFFIN PhD Molecular Endocrinology

Course and current status

1986-1994: University of Liege, Belgium.  

• 1987: M. Sc., Animal Physiology Lab
• 1993: PhD thesis, Research assistant of the Belgian National Funds for Scientific Research (FNRS), Molecular Biology and Genetic Engineering Lab.

1994-present: Inserm and Université Paris Cité, Faculty of Medicine, Necker site, Paris, France

• 1994-1996: Post-doctoral fellow of the European Community – Marie Curie fellowship, Molecular Endocrinology Lab
• 1996-2005: Associate Professor, Team leader at Molecular Endocrinology Lab
• 2006-present: Professor/Research Director, Head of "PRL/GH Pathophysiology" Lab, Institut Necker Enfants Malades (Inserm Unit 1151)
• Since 2022 : Head of Service Unit 24 / SFR Necker (technological core facilities of Necker site)

Scientific summary

Major interests

• Prostate cancer, benign prostate hyperplasia, and stem/progenitor cells (cell plasticity and therapeutic targeting)

• PRL and GH in human pathophysiology 

Major findings

• Discovery of castration-resistant luminal progenitor cells in the mouse prostate and their role in prostate tumorigenesis.

• Development of pure prolactin receptor antagonists, used worldwide in academia since 20 years.

• Identification of the first GOF natural variant of the prolactin receptor in benign breast diseases

Research tools

Translational approaches (preclinical cell/mouse models, organoids, human biocollections)